U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 00:13:26 GMT 2025
Edited
by admin
on Wed Apr 02 00:13:26 GMT 2025
Protein Type MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type IGG1|KAPPA
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
JB9647672Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Rosopatamab tetraxetan lutetium Lu-177
Common Name English
lutetium (<sup>177</sup>Lu) rosopatamab tetraxetan
INN  
Preferred Name English
Immunoglobulin G1, anti-(human prostate-specific membrane antigen) (human-Mus musculus monoclonal Huj591 ?1-chain), disulfide with human-Mus musculus monoclonal Huj591 ?-chain, dimer, N<sup>6</sup>-[2-[4,7,10-tris[(carboxy-?O)methyl]-1,4,7,10-tetraazacyc
Common Name English
TLX591
Common Name English
Lutetium (177Lu) J591 [WHO-DD]
Common Name English
<sup>177</sup> LU-DOTA-ROSOPATAMAB
Common Name English
HUJ591-GS (177LU-J591)
Common Name English
immunoglobulin G1-kappa, anti-[Homo sapiens FOLH1(folate hydrolase, prostate specific membrane antigen, PSMA)], lutetium (<sup>177<sup>Lu) radiolabelled tetraxetan conjugate
Common Name English
lutetium (<sup>177</sup>Lu) rosopatamab tetraxetan [INN]
Common Name English
H-gamma1 heavy chain (1-445) [VH Musmus/Homsap (Mus musculus IGHV1-26*01 (78.4%) -(IGHD) -IGHJ2*01 (92.9%) T123>L (110)/Homo sapiens IGHV1-69-2*01 (76.3%) -(IGHD) -IGHJ4*01 (92.9%) V124>L (111), CDR-IMGT [8.8.8] (26-33.51-58.97-104)) (1-115) -Homo sapien
Common Name English
DOTA-HUJ-591 LU-177
Common Name English
TLX-591
Common Name English
LUTETIUM (177LU) J591
Common Name English
Code System Code Type Description
SMS_ID
300000017453
Created by admin on Wed Apr 02 00:13:26 GMT 2025 , Edited by admin on Wed Apr 02 00:13:26 GMT 2025
PRIMARY
CAS
2866236-96-4
Created by admin on Wed Apr 02 00:13:26 GMT 2025 , Edited by admin on Wed Apr 02 00:13:26 GMT 2025
PRIMARY
NCI_THESAURUS
C38701
Created by admin on Wed Apr 02 00:13:26 GMT 2025 , Edited by admin on Wed Apr 02 00:13:26 GMT 2025
PRIMARY
INN
12996
Created by admin on Wed Apr 02 00:13:26 GMT 2025 , Edited by admin on Wed Apr 02 00:13:26 GMT 2025
PRIMARY
FDA UNII
JB9647672Z
Created by admin on Wed Apr 02 00:13:26 GMT 2025 , Edited by admin on Wed Apr 02 00:13:26 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_142 2_198
2_218 4_214
2_259 2_319
1_142 1_198
2_365 2_423
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_218 3_214
1_224 2_224
1_227 2_227
1_259 1_319
1_365 1_423
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_295
N 2_295
Related Record Type Details
NON-LABELED -> LABELED
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION RESIDUE_SPECIFIC K LYSINE-DOTA KTZ0L57AI1
METAL_BINDING RESIDUE_SPECIFIC LUTETIUM CATION (3+) VGE918NCOU
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL