Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C24H23N3O6S.C10H8O3S |
| Molecular Weight | 689.755 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OS(=O)(=O)C1=CC=C2C=CC=CC2=C1.CC3(C)S[C@@H]4[C@H](NC(=O)[C@H](N)C5=CC=CC=C5)C(=O)N4[C@H]3C(=O)OC6OC(=O)C7=CC=CC=C67
InChI
InChIKey=ROOMFXLKCBAVMC-WVFSJLEKSA-N
InChI=1S/C24H23N3O6S.C10H8O3S/c1-24(2)17(22(31)33-23-14-11-7-6-10-13(14)21(30)32-23)27-19(29)16(20(27)34-24)26-18(28)15(25)12-8-4-3-5-9-12;11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h3-11,15-17,20,23H,25H2,1-2H3,(H,26,28);1-7H,(H,11,12,13)/t15-,16-,17+,20-,23?;/m1./s1
| Molecular Formula | C10H8O3S |
| Molecular Weight | 208.234 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C24H23N3O6S |
| Molecular Weight | 481.521 |
| Charge | 0 |
| Count |
|
| Stereochemistry | EPIMERIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
The phthalidyl thiazolidine carboxylic ester of ampicillin, talampicillin (Talpen, Beecham), has been introduced recently to improve absorption and to reduce these side effects. After oral administration talampicillin is rapidly absorbed and hydrolysed by tissue esterases in the intestinal wall to release into the circulation ampicillin and the ester moiety, mainly 2-hydroxymethyl-benzoic acid. No unchanged talampicillin is detectable in the peripheral blood. It is not approved by the FDA for use in the United States
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of treatment with antimicrobial agents on the human colonic microflora. | 2008-12 |
|
| Kinetics of talampicillin decomposition in solutions. | 2002-05-25 |
|
| Evaluation of oral antimicrobial agent levels in tooth extraction sites. | 2001-06 |
|
| Talampicillin in the treatment and prophylaxis of urinary tract infection in children. | 1982 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:02:16 GMT 2025
by
admin
on
Mon Mar 31 23:02:16 GMT 2025
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| Record UNII |
JB791E7242
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| Record Status |
Validated (UNII)
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| Record Version |
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71953-01-0
Created by
admin on Mon Mar 31 23:02:16 GMT 2025 , Edited by admin on Mon Mar 31 23:02:16 GMT 2025
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JB791E7242
Created by
admin on Mon Mar 31 23:02:16 GMT 2025 , Edited by admin on Mon Mar 31 23:02:16 GMT 2025
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9831447
Created by
admin on Mon Mar 31 23:02:16 GMT 2025 , Edited by admin on Mon Mar 31 23:02:16 GMT 2025
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235836
Created by
admin on Mon Mar 31 23:02:16 GMT 2025 , Edited by admin on Mon Mar 31 23:02:16 GMT 2025
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PRIMARY | RxNorm |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |