FLUMECINOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H15F3O
Molecular Weight	280.2849
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(O)(C1=CC=CC=C1)C2=CC(=CC=C2)C(F)(F)F

InChI

InChIKey=DVASNQYQOZHAJN-UHFFFAOYSA-N

InChI=1S/C16H15F3O/c1-2-15(20,12-7-4-3-5-8-12)13-9-6-10-14(11-13)16(17,18)19/h3-11,20H,2H2,1H3

HIDE SMILES / InChI

Molecular Formula	C16H15F3O
Molecular Weight	280.2849
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67016914 | https://www.ncbi.nlm.nih.gov/pubmed/668788 | https://www.ncbi.nlm.nih.gov/pubmed/7918930

FLUMECINOL, a benzhydrol derivative, is a hepatic microsomal drug-metabolizing enzyme inducer. It was in clinical development for the treatment of pruritus associated with primary biliary cirrhosis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cytochromes P450 3 Target ID: Cytochromes P450 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2238704	Activator 1430

PubMed

Title	Date	PubMed
[Reducing of hepatotoxicity of antineoplastic chemotherapy and concomitant viral infection through control of liver metabolism: from experiment to clinical practice].	2001	11826485
[The drop in toxicity and the rise in the effectiveness of antineoplastic chemotherapy by correcting the activity of liver monooxygenases: from the experiment to the clinical practice].	2002	11882969
[Liver monooxygenase system inducers in the treatment of respiratory distress syndrome in newborn].	2002 Mar	11980138
Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis.	2002 Sep	12512000
[Efficacy of enzyme-inducing agents in experimental tetrachloromethane poisoning].	2003 Jul-Aug	14558353

Patents

Sample Use Guides

In Vivo Use Guide

600 mg once weekly for 3 weeks.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:13:45 UTC 2023` Edited by `admin` on `Fri Dec 15 15:13:45 UTC 2023`
Record UNII	JB0YA8LDOW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUMECINOL

Official Name

English

1-(3-TRIFLUOROMETHYLPHENYL)-1-PHENYLPROPAN-1-OL

Systematic Name

English

flumecinol [INN]

Common Name

English

.ALPHA.-ETHYL-3-(TRIFLUOROMETHYL)BENZHYDROL

Systematic Name

English

BENZENEMETHANOL, .ALPHA.-ETHYL-.ALPHA.-PHENYL-3-(TRIFLUOROMETHYL)-

Systematic Name

English

Flumecinol [WHO-DD]

Common Name

English

FLUMECINOL [MART.]

Common Name

English

ZYXORIN

Brand Name

English

FLUMECINOL [MI]

Common Name

English

3-(TRIFLUOROMETHYL)-.ALPHA.-ETHYLBENZHYDROL

Systematic Name

English

(±)-FLUMECINOL

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

2984