DYMANTHINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H43N.ClH
Molecular Weight	334.023
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCCCCCCCCCCCCCCCCCN(C)C

InChI

InChIKey=PFKRTWCFCOUBHS-UHFFFAOYSA-N

InChI=1S/C20H43N.ClH/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21(2)3;/h4-20H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	C20H43N
Molecular Weight	297.5621
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://books.google.ru/books?id=mH4ECAAAQBAJ&pg=PA131&lpg=PA131&dq=Basic+studies+on+the+anthelmintic+action+of+dymanthine+(Thelmesan) retrieved from Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Authors: JUCKER, p.131 | https://www.ncbi.nlm.nih.gov/pubmed/6045132

Dymanthine (Thelmesan) is an Anthelmintic, it is prepared as the hydrochloride and has some activity against hookworm infection, ascariasis, trichuriasis and hymenolepiasis. The drug appears to be safe, well tolerated and to cause few side effects (nausea, vomiting, headache, diarrhea, giddiness).

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Helminthiasis 39 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5833036 https://www.ncbi.nlm.nih.gov/pubmed/6045132	Primary		Approved 8429	Thelmesan Approved Use Anthelmintic

PubMed

Title	Date	PubMed
Dymanthine hydrochloride (thelmasan) in multiple intestinal helmintic infestations.	1967 Mar	6045132
[Treatment of hymenolepiasis with dymanthine HCl].	1968 May	5724219
[Treatment of ascariasis, trichuriasis, hymenolepiasis and giardiasis with single doses of Thelmesan].	1968 Oct	5675217

Patents

Sample Use Guides

In Vivo Use Guide

A dose of 50 mg/kg of dymanthine given for 1-3 days eliminates T. solium, T. saginata and H. nana worms in man.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:04:26 GMT 2023` Edited by `admin` on `Fri Dec 15 16:04:26 GMT 2023`
Record UNII	JAD662Q3U7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DYMANTHINE HYDROCHLORIDE

Official Name

English

STEARYLDIMETHYLAMINE HYDROCHLORIDE

Systematic Name

English

1-OCTADECANAMINE, N,N-DIMETHYL-, HYDROCHLORIDE

Systematic Name

English

DYMANTHINE HYDROCHLORIDE [USAN]

Common Name

English

DYMANTHINE HCL

Common Name

English

N,N-Dimethyloctadecylamine hydrochloride

Systematic Name

English

NSC-5547

Code

English

GS-1339

Code

English

DYMANTHINE HYDROCHLORIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250