Zapomeran

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 19:28:20 UTC 2023` Edited by `admin` on `Sat Dec 16 19:28:20 UTC 2023`
Nucleic Acid Type	MRNA
Nucleic Acid Subtype	TRANSGENE
Sequence Type	COMPLETE
Record UNII	J9E7RSF8K3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Zapomeran

Official Name

English

self-replicating messenger RNA (mRNA), 5'-capped, encoding codon-optimised Venezuelan equine encephalitis virus (VEEV) RNA-dependent RNA polymerase (VEEV proteins nsP1, nsP2, nsP3 and nsP4) and a full-length codon-optimised pre-fusion stabilised conforma

Common Name

English

zapomeran [INN]

Common Name

English

RNA (recombinant 5′-(m7G-(5′→5′)-ppp-Am)-capped Venezuelan equine encephalitis virus RNA-dependent RNA polymerase codon-optimized transgene plus severe acute respiratory syndrome coronavirus 2 spike pre-fusion glycoprotein [614-glycine,682-glycin

Common Name

English

Code System Code Type Description

INN

12516

Created by admin on Sat Dec 16 19:28:20 UTC 2023 , Edited by admin on Sat Dec 16 19:28:20 UTC 2023

PRIMARY

CAS

2727965-96-8

Created by admin on Sat Dec 16 19:28:20 UTC 2023 , Edited by admin on Sat Dec 16 19:28:20 UTC 2023

PRIMARY

FDA UNII

J9E7RSF8K3

Created by admin on Sat Dec 16 19:28:20 UTC 2023 , Edited by admin on Sat Dec 16 19:28:20 UTC 2023

PRIMARY

NCI_THESAURUS

C190459

Created by admin on Sat Dec 16 19:28:20 UTC 2023 , Edited by admin on Sat Dec 16 19:28:20 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_11860	11860 / 11860

Linkage	Site Range	Site Count
Phosphate	1_2-1_11860	11859 / 11859

Related Record Type Details


					B6L4N5Z4GH

SARS-COV2

TARGET->VACCINE ANTIGEN

Amount:

Related Record Type Details


					J9E7RSF8K3

Zapomeran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE INSERTIONS	[1_1]	C-TERMINUS			m2-7,3’-OGppp(m1-2’-O)Ap mRNA CAP	VNP8CZY34V