Zapomeran

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 15:48:24 GMT 2025` Edited by `admin` on `Wed Apr 02 15:48:24 GMT 2025`
Nucleic Acid Type	MRNA
Sequence Type	COMPLETE
Record UNII	J9E7RSF8K3
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Zapomeran

Official Name

English

RNA (recombinant 5?-(m7G-(5??5?)-ppp-Am)-capped Venezuelan equine encephalitis virus RNA-dependent RNA polymerase codon-optimized transgene plus severe acute respiratory syndrome coronavirus 2 spike pre-fusion glycoprotein [614-glycine,682-glycine,683-se

Preferred Name

English

self-replicating messenger RNA (mRNA), 5'-capped, encoding codon-optimised Venezuelan equine encephalitis virus (VEEV) RNA-dependent RNA polymerase (VEEV proteins nsP1, nsP2, nsP3 and nsP4) and a full-length codon-optimised pre-fusion stabilised conforma

Common Name

English

mRNA-2105

Common Name

English

zapomeran [INN]

Common Name

English

Code System Code Type Description

INN

12516

Created by admin on Wed Apr 02 15:48:24 GMT 2025 , Edited by admin on Wed Apr 02 15:48:24 GMT 2025

PRIMARY

SMS_ID

300000040151

Created by admin on Wed Apr 02 15:48:24 GMT 2025 , Edited by admin on Wed Apr 02 15:48:24 GMT 2025

PRIMARY

CAS

2727965-96-8

Created by admin on Wed Apr 02 15:48:24 GMT 2025 , Edited by admin on Wed Apr 02 15:48:24 GMT 2025

PRIMARY

FDA UNII

J9E7RSF8K3

Created by admin on Wed Apr 02 15:48:24 GMT 2025 , Edited by admin on Wed Apr 02 15:48:24 GMT 2025

PRIMARY

NCI_THESAURUS

C190459

Created by admin on Wed Apr 02 15:48:24 GMT 2025 , Edited by admin on Wed Apr 02 15:48:24 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_11847	11847 / 11847

Linkage	Site Range	Site Count
Phosphate	1_2-1_11847	11846 / 11846

Related Record Type Details


					B6L4N5Z4GH

SARS-COV2

TARGET->VACCINE ANTIGEN

Amount:

Related Record Type Details


					J9E7RSF8K3

Zapomeran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE INSERTIONS	[1_1]	C-TERMINUS			UNSPECIFIED SUBSTANCE	72499344 (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Signal P	NUCLEIC ACID FEATURE
3’ UTR	NUCLEIC ACID FEATURE
intergenic	NUCLEIC ACID FEATURE
5’ UTR	NUCLEIC ACID FEATURE
Transgene	NUCLEIC ACID FEATURE
Replicase	NUCLEIC ACID FEATURE
polyA	NUCLEIC ACID FEATURE