Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C9H13NO2.BrH |
| Molecular Weight | 248.117 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Br.CNCCC1=CC=C(O)C(O)=C1
InChI
InChIKey=ACICAVVXAAEHEM-UHFFFAOYSA-N
InChI=1S/C9H13NO2.BrH/c1-10-5-4-7-2-3-8(11)9(12)6-7;/h2-3,6,10-12H,4-5H2,1H3;1H
| Molecular Formula | BrH |
| Molecular Weight | 80.912 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C9H13NO2 |
| Molecular Weight | 167.205 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Epinine or deoxyepinephrine is an active form of Ibopamine, which is used as a cardiovascular agent in congestive heart failure. Epinine is a stimulant of alpha-adrenoceptor activities: alpha-1 and alpha-2. Experiments on pig’s eyes have shown that epinine can be a promising candidate substance for intraoperative (e.g., cataract surgery) intracameral use in humans.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P07550|||Q53GA6|||Q9UCZ3 Gene ID: 154.0 Gene Symbol: ADRB2 Target Organism: Homo sapiens (Human) |
|||
Target ID: P08913 Gene ID: 150.0 Gene Symbol: ADRA2A Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
| Title | Date | PubMed |
|---|---|---|
| Comparison of the central effects of dopamine and epinine. | 1973 |
|
| Electrophysiological and mechanical studies of frog heart adrenoceptor stimulation by epinine. | 1981 Dec |
|
| Comparison of the cardiovascular actions of dopamine and epinine in the dog. | 1985 Apr |
|
| Analysis of epinine and its metabolites in man after oral administration of its pro-drug ibopamine using high-performance liquid chromatography with electrochemical detection. | 1986 Aug 22 |
|
| [Mechanism of action of ibopamine: pharmacological effects of epinine and other metabolites]. | 1988 Jan |
|
| Effect of ibopamine and the active metabolite epinine on the catecholamine content of rat hypothalamus and brainstem in vitro. | 1988 Nov |
|
| Effect of dopamine, ibopamine, and epinine on alpha- and beta-adrenoceptors in canine pulmonary circulation. | 1989 |
Patents
Sample Use Guides
in the dog: 3 and 6 micrograms/kg/min of epinine
Route of Administration:
Intravenous
One hundred twelve eyes from newly slaughtered pigs were used. After pretreatment with 20 mg intracameral acetylcholine to give miosis, 0.15 mL epinine was given as an intracameral injection. The pupils were filmed during 90 seconds with a video camera connected to an operation microscope, and the mean pupil diameters were measured from the video recordings. In 37 additional eyes, 0.15 mL vehicle, 1.5% epinine was injected intracamerally, and the eyes were kept on ice overnight. Epinine had a significantly larger mydriatic effect than phenylephrine at equal concentrations.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 19:48:10 UTC 2023
by
admin
on
Sat Dec 16 19:48:10 UTC 2023
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| Record UNII |
J9AP3NQW36
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| Record Status |
Validated (UNII)
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| Record Version |
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18191-22-5
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19794533
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J9AP3NQW36
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admin on Sat Dec 16 19:48:10 UTC 2023 , Edited by admin on Sat Dec 16 19:48:10 UTC 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
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