Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H14N2 |
| Molecular Weight | 162.2316 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C1CN(CCN1)C2=CC=CC=C2
InChI
InChIKey=YZTJYBJCZXZGCT-UHFFFAOYSA-N
InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
| Molecular Formula | C10H14N2 |
| Molecular Weight | 162.2316 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Oxidation of fluoroquinolone antibiotics and structurally related amines by chlorine dioxide: Reaction kinetics, product and pathway evaluation. | 2010-12 |
|
| Search for influence of spatial properties on affinity at α1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin. | 2010-10-15 |
|
| Analysis of phenylpiperazine-like stimulants in human hair as trimethylsilyl derivatives by gas chromatography-mass spectrometry. | 2010-10-01 |
|
| Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds. | 2010-09-15 |
|
| [3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopamine D(3) and D(2) receptor density ratio in the caudate-putamen. | 2010-06 |
|
| Design of new dopamine D2 receptor ligands: biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581. | 2010-05-01 |
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| Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16). | 2010-03-25 |
|
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. | 2010-03-01 |
|
| Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways. | 2010-03 |
|
| Molecular modeling study of 4-phenylpiperazine and 4-phenyl-1,2,3,6-tetrahydropyridine derivatives: a new step towards the design of high-affinity 5-HT1A ligands. | 2010-02-01 |
|
| Synthesis and pharmacological evaluation of new 1-[3-(4-phenylpiperazin-1-yl)-propyl]- and 1-[3-(4-phenylpiperidine)-propyl]- 3-aryl-3-alkyl-pyrrolidin-2-one derivatives with antiarrhythmic and antihypertensive activity. | 2010-01-07 |
|
| Animal violence demystified. | 2010 |
|
| [(18)F]-labeled 2-methoxyphenylpiperazine derivative as a potential brain positron emission tomography imaging agent. | 2009-11 |
|
| Construction of drug screening cell model and application to new compounds inhibiting FITC-fibrinogen binding to CHO cells expressing human alphaIIbbeta3. | 2009-09-15 |
|
| [(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin- 1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterization. | 2009-09 |
|
| Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. | 2009-08-13 |
|
| Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases. | 2009-07-01 |
|
| Acaricidal properties of piperazine and its derivatives against house-dust and stored-food mites. | 2009-06 |
|
| Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist. | 2009-05-28 |
|
| Application of a library of artificial receptors formed by the self-organization of N-lipidated peptides immobilized on cellulose in studying the effects of the incorporation of a fluorine atom. | 2009-04-17 |
|
| SONU20176289, a compound combining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression. | 2008-11-19 |
|
| Probe compounds to quantify cation exchange and complexation interactions of ciprofloxacin with soils. | 2008-11-15 |
|
| Evaluation of D2 and D3 dopamine receptor selective compounds on L-dopa-dependent abnormal involuntary movements in rats. | 2008-11-05 |
|
| Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues. | 2008-09-01 |
|
| FT-IR spectroscopic investigation of some Hofmann type complexes: M(1-phenylpiperazine)2Ni(CN)4 (M=Ni, Co, Cd, Pd or Mn). | 2008-07 |
|
| Synthesis, alpha 1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin. | 2008-06-01 |
|
| Pharmacokinetic evaluation of LASSBio-579: an N-phenylpiperazine antipsychotic prototype. | 2008-06 |
|
| (Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists. | 2008-04-24 |
|
| Determination of lipophilicity of alpha-(4-phenylpiperazine) derivatives of N-benzylamides using chromatographic and computational methods. | 2008-04 |
|
| Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581. | 2008-03 |
|
| Patented small molecule inhibitors in the ubiquitin proteasome system. | 2007-11-22 |
|
| Two new phenylpiperazines with atypical antipsychotic potential. | 2007-11-01 |
|
| From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor. | 2007-07-26 |
|
| FT-IR and NMR investigation of 1-phenylpiperazine: a combined experimental and theoretical study. | 2007-07 |
|
| Synthesis and in vitro evaluation of substituted phenyl-piperazinyl-phenyl oxazolidinones against Gram-positive bacteria. | 2007-04 |
|
| Identification of metabolites produced from N-phenylpiperazine by Mycobacterium spp. | 2007-03 |
|
| Hepatic metabolism of two alpha-1A-adrenergic receptor antagonists, phthalimide-phenylpiperazine analogs (RWJ-69205 and RWJ-69471), in the rat, dog and human. | 2007-02-24 |
|
| Trazodone for Alzheimer's disease: a naturalistic follow-up study. | 2007-02-07 |
|
| Adsorption and oxidation of fluoroquinolone antibacterial agents and structurally related amines with goethite. | 2007-01 |
|
| Novel potent neuropeptide Y Y5 receptor antagonists: synthesis and structure-activity relationships of phenylpiperazine derivatives. | 2006-11-15 |
|
| Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. | 2006-08-24 |
|
| BACE-1 inhibitory activities of new substituted phenyl-piperazine coupled to various heterocycles: chromene, coumarin and quinoline. | 2006-04-01 |
|
| Binding and photocleavage of cationic porphyrin-phenylpiperazine hybrids to DNA. | 2006-02-01 |
|
| In vitro metabolism studies of (18)F-labeled 1-phenylpiperazine using mouse liver S9 fraction. | 2006-02 |
|
| Synthesis of potent and selective serotonin 5-HT1B receptor ligands. | 2005-11-01 |
|
| Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents. | 2005-11-01 |
|
| Comorbidity issues in the pharmacological treatment of Pathological Gambling: a critical review. | 2005-10-10 |
|
| Pharmacokinetics and tissue distribution of a new heterocyclic N-phenylpiperazine derivative (LASSBio-581) in rats. | 2005-10 |
|
| [A study of physicochemical properties of 2-, 3-, 4-alkoxyphenylcarbamic acid derivatives with a substituted N-phenylpiperazine moiety in the basic part]. | 2005-09 |
|
| Fluorous reagents and scavengers versus solid-supported reagents and scavengers, a reaction rate and kinetic comparison. | 2005 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:23:35 GMT 2025
by
admin
on
Mon Mar 31 19:23:35 GMT 2025
|
| Record UNII |
J9225CBI7D
|
| Record Status |
Validated (UNII)
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| Record Version |
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Systematic Name | English | ||
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Preferred Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
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DTXSID8057855
Created by
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C031503
Created by
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7096
Created by
admin on Mon Mar 31 19:23:35 GMT 2025 , Edited by admin on Mon Mar 31 19:23:35 GMT 2025
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Phenylpiperazine
Created by
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202-165-6
Created by
admin on Mon Mar 31 19:23:35 GMT 2025 , Edited by admin on Mon Mar 31 19:23:35 GMT 2025
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J9225CBI7D
Created by
admin on Mon Mar 31 19:23:35 GMT 2025 , Edited by admin on Mon Mar 31 19:23:35 GMT 2025
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92-54-6
Created by
admin on Mon Mar 31 19:23:35 GMT 2025 , Edited by admin on Mon Mar 31 19:23:35 GMT 2025
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| Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
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| Related Record | Type | Details | ||
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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