1-PHENYLPIPERAZINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H14N2
Molecular Weight	162.2316
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1CN(CCN1)C2=CC=CC=C2

InChI

InChIKey=YZTJYBJCZXZGCT-UHFFFAOYSA-N

InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2

HIDE SMILES / InChI

Molecular Formula	C10H14N2
Molecular Weight	162.2316
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization.	2002 Apr	11888550
New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes.	2003 Jul 3	12825930
Rhodium-catalyzed anti-Markovnikov hydroamination of vinylarenes.	2003 May 14	12733880
Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity.	2003 Oct 1	13129578
Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: novel antagonists for the vascular 5-HT1B receptor.	2004 Apr	15072840
Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.	2004 Apr 22	15084133
Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype.	2004 Aug 2	15225707
Synthesis of novel N-alkyl carbamates of a-substituted amides of g-hydroxybutyric acid as potential acetylcholinesterase inhibitors.	2004 Dec	15909954
1- and 2-substituted naphthalenes: a new class of potential hypotensive agents.	2004 Jun 7	15125935
Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential: a case study with structurally related piperazines.	2004 Mar	15088636
Discovery of a potent and selective alpha v beta 3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model.	2004 May 17	15109653
Prediction of genotoxicity of chemical compounds by statistical learning methods.	2005 Jun	15962942
Oxidative transformation of fluoroquinolone antibacterial agents and structurally related amines by manganese oxide.	2005 Jun 15	16047783
Synthesis and biological evaluation of new thiazolyl/benzothiazolyl-amides, derivatives of 4-phenyl-piperazine.	2005 Nov-Dec	16040029
Complete assignments of 1H and 13C NMR data for ten phenylpiperazine derivatives.	2005 Oct	16041776
Hepatic metabolism of two alpha-1A-adrenergic receptor antagonists, phthalimide-phenylpiperazine analogs (RWJ-69205 and RWJ-69471), in the rat, dog and human.	2006 Oct-Dec	17315538
Adsorption and oxidation of fluoroquinolone antibacterial agents and structurally related amines with goethite.	2007 Jan	17083963
FT-IR and NMR investigation of 1-phenylpiperazine: a combined experimental and theoretical study.	2007 Jul	17110160
Identification of metabolites produced from N-phenylpiperazine by Mycobacterium spp.	2007 Mar	17186210
Determination of lipophilicity of alpha-(4-phenylpiperazine) derivatives of N-benzylamides using chromatographic and computational methods.	2008 Apr	18059060
FT-IR spectroscopic investigation of some Hofmann type complexes: M(1-phenylpiperazine)2Ni(CN)4 (M=Ni, Co, Cd, Pd or Mn).	2008 Jul	18068422
Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581.	2008 Mar	18082872
Acaricidal properties of piperazine and its derivatives against house-dust and stored-food mites.	2009 Jun	19253419
Evaluation of D2 and D3 dopamine receptor selective compounds on L-dopa-dependent abnormal involuntary movements in rats.	2009 May-Jun	19371586
Application of a library of artificial receptors formed by the self-organization of N-lipidated peptides immobilized on cellulose in studying the effects of the incorporation of a fluorine atom.	2009 May-Jun	19368356
Animal violence demystified.	2010	20407576
Oxidation of fluoroquinolone antibiotics and structurally related amines by chlorine dioxide: Reaction kinetics, product and pathway evaluation.	2010 Dec	20708211
Design of new dopamine D2 receptor ligands: biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581.	2010 May 1	20363131
Analysis of phenylpiperazine-like stimulants in human hair as trimethylsilyl derivatives by gas chromatography-mass spectrometry.	2010 Oct 1	20800845
Search for influence of spatial properties on affinity at α1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin.	2010 Oct 15	20813529
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds.	2010 Sep 15	20667740

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:23:35 GMT 2025` Edited by `admin` on `Mon Mar 31 19:23:35 GMT 2025`
Record UNII	J9225CBI7D
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

1-PHENYLPIPERAZINE

Systematic Name

English

N-PHENYLDIETHYLENEDIAMINE

Preferred Name

English

PHENYLPIPERAZINE, 1-

Systematic Name

English

LEVODROPROPIZINE IMPURITY B [EP IMPURITY]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID8057855