MANIFAXINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H15F2NO2
Molecular Weight	243.2498
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H]1CO[C@](O)([C@H](C)N1)C2=CC(F)=CC(F)=C2

InChI

InChIKey=OZGPVYJHWWPEFT-RGNHYFCHSA-N

InChI=1S/C12H15F2NO2/c1-7-6-17-12(16,8(2)15-7)9-3-10(13)5-11(14)4-9/h3-5,7-8,15-16H,6H2,1-2H3/t7-,8+,12-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C12H15F2NO2
Molecular Weight	243.2498
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://adisinsight.springer.com/drugs/800006906 | https://www.ncbi.nlm.nih.gov/pubmed/16272960 | https://www.ncbi.nlm.nih.gov/pubmed/12162627

Manifaxine (GW 320659) is a highly selective neuronal norepinephrine and dopamine re-uptake inhibitor. It has been in phase II clinical trials by GlaxoSmithKline for the treatment of attention deficit hyperactivity disorder and obesity. Manifaxine development has been discontinued.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
The impact of medications on quality of life in attention-deficit hyperactivity disorder: a systematic review.	2010-10	20839896
Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects.	2005-12	16272960

Sample Use Guides

In Vivo Use Guide

a multicenter, open-label, dose-titration study of seven daily dose levels of manifaxine (GW 320659): 1.25, 2.5, 5, 7.5,10,12.5, and 15 mg.

Route of Administration: Unknown

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:31:48 GMT 2025` Edited by `admin` on `Wed Apr 02 08:31:48 GMT 2025`
Record UNII	J8IE53G2IV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

manifaxine [INN]

Preferred Name

English

MANIFAXINE

Official Name

English

(2S,3S,5R)-2-(3,5-DIFLUOROPHENYL)-3,5-DIMETHYLMORPHOLIN-2-OL

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29747