5,7-Dimethoxyflavone

COC1=CC2=C(C(=O)C=C(O2)C3=CC=CC=C3)C(OC)=C1

InChIKey=JRFZSUMZAUHNSL-UHFFFAOYSA-N

InChI=1S/C17H14O4/c1-19-12-8-15(20-2)17-13(18)10-14(21-16(17)9-12)11-6-4-3-5-7-11/h3-10H,1-2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
ATP-binding cassette sub-family G member 2 16 Target ID: CHEMBL5393 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21354800	Inhibitor 8297	9.2 µM [IC50]
Cytochrome P450 1A1 31 Target ID: CHEMBL2231 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15661813	Inhibitor 8297	0.8 µM [IC50]
Human immunodeficiency virus type 1 protease 35 Target ID: CHEMBL243 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16964717	Inhibitor 8297	19.0 µM [IC50]
cGMP-specific 3',5'-cyclic phosphodiesterase 6 Target ID: Q8CG03 Gene ID: 242202.0 Gene Symbol: Pde5a Target Organism: Mus musculus (Mouse) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21884777	Inhibitor 8297	10.64 µM [IC50]

PubMed

Title	Date	PubMed
5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice.	2011 May	21279423
5,7-Dimethoxyflavone, an activator of PPARα/γ, inhibits UVB-induced MMP expression in human skin fibroblast cells.	2012 Mar	22379967
Effect of the active ingredient of Kaempferia parviflora, 5,7-dimethoxyflavone, on the pharmacokinetics of midazolam.	2018 Jun	29550915
Effect of 5,7-dimethoxyflavone on Bcrp1-mediated transport of sorafenib in vitro and in vivo in mice.	2018 May 30	29425861

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:13:40 GMT 2023` Edited by `admin` on `Fri Dec 15 19:13:40 GMT 2023`
Record UNII	J8HQQ4R4F2
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

5,7-Dimethoxyflavone

Common Name

English

Dimethoxyflavone, 5,7-

Systematic Name

English

5,7-dimethoxy-2-phenylchromen-4-one

Systematic Name

English

Chrysin dimethyl ether

Common Name

English

5,7-Dimethoxy-2-phenyl-4H-1-benzopyran-4-one

Systematic Name

English

4H-1-Benzopyran-4-one, 5,7-dimethoxy-2-phenyl-

Systematic Name

English

NSC-741743

Code

English

Code System Code Type Description

CAS

21392-57-4