Bemremeran

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NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 20:47:57 GMT 2025` Edited by `admin` on `Wed Apr 02 20:47:57 GMT 2025`
Nucleic Acid Type	MRNA
Sequence Origin	VIRAL
Sequence Type	COMPLETE
Record UNII	J87X96APT2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RNA (recombinant 5?-(m7G-(5??5?)-ppp-Am)-capped severe acute respiratory syndrome coronavirus 2 XBB.1.5 variant (1-13)-(315-537)-spike glycoprotein precursor [534-serine] plus human ?-globin 5?- and 3?-untranslated flanking region-containing poly(A)-tail

Preferred Name

English

Bemremeran

Official Name

English

bemremeran [INN]

Common Name

English

messenger RNA (mRNA), 5'-capped, encoding the codon-optimized receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein (Omicron variant XBB.1.5; based upon GISAID EPI_ISL_16433058), with a c

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C206881

Created by admin on Wed Apr 02 20:47:57 GMT 2025 , Edited by admin on Wed Apr 02 20:47:57 GMT 2025

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INN

13295

Created by admin on Wed Apr 02 20:47:57 GMT 2025 , Edited by admin on Wed Apr 02 20:47:57 GMT 2025

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CAS

2931519-21-8

Created by admin on Wed Apr 02 20:47:57 GMT 2025 , Edited by admin on Wed Apr 02 20:47:57 GMT 2025

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FDA UNII

J87X96APT2

Created by admin on Wed Apr 02 20:47:57 GMT 2025 , Edited by admin on Wed Apr 02 20:47:57 GMT 2025

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SMS_ID

300000054771

Created by admin on Wed Apr 02 20:47:57 GMT 2025 , Edited by admin on Wed Apr 02 20:47:57 GMT 2025

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Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_1024	1024 / 1024

Linkage	Site Range	Site Count
Phosphate	1_2-1_1024	1023 / 1023

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SARS-COV2 B.1.1.529 VARIANT

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Related Record Type Details


					J87X96APT2

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS	G		5'-GUANOSINE-M-RNA-CAP-1-3'-PHOSPHATE	T0HQY09X7B
NUCLEOSIDE_SUBSTITUTION		RESIDUE_SPECIFIC	C		5-METHYLCYTOSINE	6R795CQT4H
NUCLEOSIDE_SUBSTITUTION		RESIDUE_SPECIFIC	U		THYMINE	QR26YLT7LT