U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Alicaforsen is an antisense oligonucleotide targeted to down regulate the production of ICAM-1, a cell surface receptor which is involved in the process of inflammation. Alicaforsen selectively inhibits ICAM‑1 gene expression. Over-expression of ICAM‑1 occurs in a wide variety of inflammatory disorders, including ulcerative colitis (UC), pouchitis and tissues in the eye, gastrointestinal teact, lungs and skin. Alicaforsen is currently in development for the treatment of IBD. An enema formulation is currently in a pivotal Phase 3 study agreed with U.S., Canadian and European regulatory agencies in patients with active pouchitis. The study has completed enrollment of patients to approximately 40 trial centres across the U.S., Canada, Europe, and Israel, and is expected to report preliminary data in H1 2019. Under a rolling submission agreement with the FDA, Atlantic Healthcare has filed the nonclinical data package of its New Drug Application (NDA) for alicaforsen to treat pouchitis with the regulator. Alicaforsen has also been granted FDA Fast-Track designation, plus U.S. and European Orphan Drug designations for this indication. ​

Approval Year

PubMed

PubMed

TitleDatePubMed
Alicaforsen. Isis Pharmaceuticals.
2001 Oct
Gateways to clinical trials.
2006 Dec
Alicaforsen in the treatment of pouchitis.
2017 Nov

Sample Use Guides

Pouchitis: Alicaforsen enema, 240mg once daily for 6 weeks
Route of Administration: Rectal
Alicaforsen demonstrated hyperbolic, mixed-type inhibition of chromogenic substrate cleavage by factor IXa (K(I) = 88 nM). Equilibrium binding studies with fluorescein-labeled Alicaforsen demonstrated a similar affinity (K(D) = 92 nM) for the PS ODN-factor IX interaction.
Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 17:40:36 UTC 2023
Edited
by admin
on Sat Dec 16 17:40:36 UTC 2023
Nucleic Acid Subtype
Sequence Type P0LYNUCLEOTIDE
Record UNII
J8435V445B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALICAFORSEN
INN   MI   WHO-DD  
INN  
Official Name English
ALICAFORSEN [MI]
Common Name English
Alicaforsen [WHO-DD]
Common Name English
alicaforsen [INN]
Common Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/09/641
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
FDA ORPHAN DRUG 260808
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
Code System Code Type Description
FDA UNII
J8435V445B
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
PRIMARY
NCI_THESAURUS
C169771
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
PRIMARY
EPA CompTox
DTXSID701030532
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
PRIMARY
ChEMBL
CHEMBL2108326
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
PRIMARY
MERCK INDEX
m1507
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
PRIMARY Merck Index
INN
8135
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
PRIMARY
DRUG BANK
DB06224
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
PRIMARY
PUBCHEM
16197725
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
PRIMARY
ChEMBL
CHEMBL2108895
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
PRIMARY
EVMPD
SUB130333
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
PRIMARY
CAS
185229-68-9
Created by admin on Sat Dec 16 17:40:37 UTC 2023 , Edited by admin on Sat Dec 16 17:40:37 UTC 2023
PRIMARY
Sugar Site Range Site Count
Deoxyribose (DNA) 1_1-1_20 20 / 20
Linkage Site Range Site Count
Phosporothioate 1_2-1_20 19 / 19
Related Record Type Details
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY