AGANEPAG ETHANEDIOL

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H35NO5S
Molecular Weight	473.625
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC[C@H](O)C1=CC=C(C=C1)N2[C@@H](CCCC3=CC=C(S3)C(=O)OCCO)CCC2=O

InChI

InChIKey=VTFVKRFGCDQSBY-REWPJTCUSA-N

InChI=1S/C26H35NO5S/c1-2-3-4-8-23(29)19-9-11-21(12-10-19)27-20(13-16-25(27)30)6-5-7-22-14-15-24(33-22)26(31)32-18-17-28/h9-12,14-15,20,23,28-29H,2-8,13,16-18H2,1H3/t20-,23-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C26H35NO5S
Molecular Weight	473.625
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.genome.jp/dbget-bin/www_bget?dr:D09862https://patents.google.com/patent/WO2014078434A1 | https://www.genome.jp/dbget-bin/www_bget?dr:D09861https://www.genome.jp/dbget-bin/www_bget?dr:D09863 | https://www.ncbi.nlm.nih.gov/pubmed/29669171

Aganepag isopropyl, an IOP-lowering agent, is an antiglaucoma agent. It is a selective EP2 receptor agonist.

Originator

Approval Year

PubMed

Title	Date	PubMed
Prostaglandin analogues and nitric oxide contribution in the treatment of ocular hypertension and glaucoma.	2019-04	29669171

Patents

Sample Use Guides

In Vitro Use Guide

Aganepag (Compound 3) is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:42:45 GMT 2025` Edited by `admin` on `Mon Mar 31 19:42:45 GMT 2025`
Record UNII	J7L0ZSN36Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AGN-212409

Preferred Name

English

AGANEPAG ETHANEDIOL

Official Name

English

Aganepag ethanediol [WHO-DD]

Common Name

English

AGANEPAG ETHANEDIOL [USAN]

Common Name

English

2-HYDROXYETHYL 5-(3-((2S)-1-(4-((1S)-1-HYDROXYHEXYL)PHENYL)-5-OXOPYRROLIDIN-2- YL)PROPYL)THIOPHENE-2-CARBOXYLATE

Systematic Name

English

2-THIOPHENECARBOXYLIC ACID, 5-(3-((2S)-1-(4-((1S)-1-HYDROXYHEXYL)PHENYL)-5-OXO-2- PYRROLIDINYL)PROPYL)-, 2-HYDROXYETHYL ESTER

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29705