Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H9ClF2N2O2 |
| Molecular Weight | 310.683 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC1=CC=CC(F)=C1C(=O)NC(=O)NC2=CC=C(Cl)C=C2
InChI
InChIKey=QQQYTWIFVNKMRW-UHFFFAOYSA-N
InChI=1S/C14H9ClF2N2O2/c15-8-4-6-9(7-5-8)18-14(21)19-13(20)12-10(16)2-1-3-11(12)17/h1-7H,(H2,18,19,20,21)
| Molecular Formula | C14H9ClF2N2O2 |
| Molecular Weight | 310.683 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Diflubenzuron is a direct-acting insecticide normally applied directly to plants or water. Diflubenzuron, besides its use in agriculture, horticulture and forestry against larvae of Lepidoptera, Coleoptera, Diptera, Hymenoptera, and in public health against larvae of mosquitoes, is used as a veterinary drug for the treatment of sea lice infestations in Atlantic salmon. Diflubenzuron acts by interference with the synthesis of chitin. It is reported that public exposure to diflubenzuron through either food or drinking-water is negligible.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL613468 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21268527 |
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Target ID: Sulfonylurea receptor of Blattella germanica |
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Target ID: GO:0006031 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15262279 |
65.0 nM [Kd] |
PubMed
| Title | Date | PubMed |
|---|---|---|
| A method for eradicating amphipod parasites (hyperiidae) from host jellyfish, Chrysaora fuscescens (Brandt, 1835), in a closed recirculating system. | 2009-03 |
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| Effects of benzoylphenylurea on chitin synthesis and orientation in the cuticle of the Drosophila larva. | 2009-03 |
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| Resistance to benzoylphenyl urea insecticides in Australian populations of the sheep body louse. | 2008-12 |
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| Resistance to insect growth regulator insecticides in populations of sheep lice as assessed by a moulting disruption assay. | 2008-12 |
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| [Simultaneous determination of diflubenzuron and triflumuron residues in greasy wool using high performance liquid chromatography]. | 2008-11 |
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| Response of citrus peelminer Marmara gulosa Guillén and Davis (Lepidoptera: Gracillariidae) stages to various insecticides. | 2008-11 |
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| Effects of metabolic inhibitors on activity of Cry1Ab toxin to inhibit growth of Ephestia kuehniella larvae. | 2008-10 |
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| Effectiveness of pyriproxyfen and diflubenzuron formulations as larvicides against Aedes aegypti. | 2008-09 |
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| Acute effects of diflubenzuron on the freshwater fish Prochilodus lineatus. | 2008-09 |
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| Molecular phylogeny and population structure of the codling moth (Cydia pomonella) in Central Europe: I. Ancient clade splitting revealed by mitochondrial haplotype markers. | 2008-09 |
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| Chitinase is stored and secreted from the inner body of microfilariae and has a role in exsheathment in the parasitic nematode Brugia malayi. | 2008-09 |
|
| Determination of photoirradiated high polar benzoylureas in tomato by HPLC with luminol chemiluminescence detection. | 2008-08-15 |
|
| Availability of insecticidal molecules to control Aedes albopictus (Skuse). | 2008-06 |
|
| Chitin in the peritrophic membrane of Acarus siro (Acari: Acaridae) as a target for novel acaricides. | 2008-06 |
|
| Joint effects of density dependence and toxicant exposure on Drosophila melanogaster populations. | 2008-06 |
|
| Variations of plasmid content in Rickettsia felis. | 2008-05-28 |
|
| Transfer of fat-soluble pesticides from contaminated feed to poultry tissues and eggs. | 2008-05 |
|
| Field evaluation of the bioefficacy of diflubenzuron (Dimilin) against container-breeding Aedes sp. mosquitoes. | 2008-04 |
|
| The ecological impact of four IGR insecticides in adults of Hyposoter didymator (Hym., Ichneumonidae): pharmacokinetics approach. | 2008-04 |
|
| Defence mechanisms against insecticides temephos and diflubenzuron in the mosquito Aedes caspius: the P-glycoprotein efflux pumps. | 2008-03 |
|
| Method development for the determination of selected pesticides on tobacco by high-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry. | 2008-02-15 |
|
| Efficacy results of insecticides against Cydia pomonella, the codling moth, in Belgium during the last decade (1998-2007). | 2008 |
|
| Pharmacogenetic and metabolic differences between dog breeds: their impact on canine medicine and the use of the dog as a preclinical animal model. | 2008 |
|
| Comparative studies on effects of three chitin synthesis inhibitors on common malaria mosquito (Diptera: Culicidae). | 2007-11 |
|
| Determination of benzoylurea insecticide residues in tomatoes by high-performance liquid chromatography with ultraviolet-diode array and atmospheric pressure chemical ionization-mass spectrometry detection. | 2007-10-25 |
|
| Insecticidal resistance and cross-resistance in populations of Cydia pomonella (Lepidoptera: Tortricidae) in central Europe. | 2007-10 |
|
| Treatment of natural infestations of the biting louse (Werneckiella equi) on horses using triflumuron, a benzoylurea derivative insect growth regulator. | 2007-09-30 |
|
| Insecticide resistance in potential vector mosquitoes for West Nile virus in Japan. | 2007-09 |
|
| Diversity of insecticide resistance mechanisms and spectrum in European populations of the codling moth, Cydia pomonella. | 2007-09 |
|
| Ovicidal and larvicidal effectiveness of insecticides applied by dipping apples on the small fruit tortrix Grapholita lobarzewskii. | 2007-07 |
|
| A comparative study of micellar and microemulsion EKC for the analysis of benzoylurea insecticides and their analogs. | 2007-06 |
|
| Simulated field evaluation of the efficacy of two formulations of diflubenzuron, a chitin synthesis inhibitor against larvae of Aedes aegypti (L.) (Diptera: Culicidae) in water-storage containers. | 2007-03 |
|
| Synergism between cis-permethrin and benzoyl phenyl urea insect growth regulators against Aedes aegypti larvae. | 2007-03 |
|
| Laboratory evaluation of diflubenzuron as a feed-through for control of immature sand flies (Diptera: Psychodidae). | 2007-03 |
|
| New method for the photo-chemiluminometric determination of benzoylurea insecticides based on acetonitrile chemiluminescence. | 2007-03 |
|
| Great tits (Parus major) reduce caterpillar damage in commercial apple orchards. | 2007-02-07 |
|
| Safety of elevated dosages of a 0.24% diflubenzuron pellet administered orally to horses. | 2007 |
|
| Susceptibility of Aedes aegypti (L) to the insect growth regulators diflubenzuron and methoprene in Uberlândia, State of Minas Gerais. | 2006-12-04 |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006-11 |
|
| Characterization of a chitin synthase cDNA and its increased mRNA level associated with decreased chitin synthesis in Anopheles quadrimaculatus exposed to diflubenzuron. | 2006-09 |
|
| Fragmentation study and analysis of benzoylurea insecticides and their analogs by liquid chromatography-electrospray ionization-mass spectrometry. | 2006-08-15 |
|
| Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomonella (L.). | 2006-08 |
|
| Hazards and uptake of chitin synthesis inhibitors in bumblebees Bombus terrestris. | 2006-08 |
|
| Efficacy of diflubenzuron, a chitin synthesis inhibitor, against Culex pipiens larvae in septic tank water. | 2006-06 |
|
| Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system. | 2006-06 |
|
| Viewpoint: Policy requirements for protecting wildlife from endocrine disruptors. | 2006-04 |
|
| [An outbreak of Plasmodium vivax malaria in Kyrghyzstan]. | 2006-03-28 |
|
| Evaluation of toxicity of two pesticides: flucycloxuron and diflubenzuron on a cellular model, Paramecium sp. | 2006 |
|
| The melon fruit fly, Bactrocera cucurbitae: a review of its biology and management. | 2005-12-06 |
|
| Laboratory and field evaluation of Hilmilin against mosquitoes. | 2005-12 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:42:23 GMT 2025
by
admin
on
Mon Mar 31 18:42:23 GMT 2025
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| Record UNII |
J76U6ZSI8D
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| Record Status |
Validated (UNII)
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| Record Version |
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WHO-VATC |
QP53BC02
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EPA PESTICIDE CODE |
108201
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D004132
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100000141123
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J76U6ZSI8D
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DIFLUBENZURON
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37123
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DTXSID1024049
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34703
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J76U6ZSI8D
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35367-38-5
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diflubenzuron
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1665336
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m4431
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6611
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SUB90869
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252-529-3
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