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Details

Stereochemistry ACHIRAL
Molecular Formula C14H9ClF2N2O2
Molecular Weight 310.683
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIFLUBENZURON

SMILES

FC1=CC=CC(F)=C1C(=O)NC(=O)NC2=CC=C(Cl)C=C2

InChI

InChIKey=QQQYTWIFVNKMRW-UHFFFAOYSA-N
InChI=1S/C14H9ClF2N2O2/c15-8-4-6-9(7-5-8)18-14(21)19-13(20)12-10(16)2-1-3-11(12)17/h1-7H,(H2,18,19,20,21)

HIDE SMILES / InChI

Molecular Formula C14H9ClF2N2O2
Molecular Weight 310.683
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Diflubenzuron is a direct-acting insecticide normally applied directly to plants or water. Diflubenzuron, besides its use in agriculture, horticulture and forestry against larvae of Lepidoptera, Coleoptera, Diptera, Hymenoptera, and in public health against larvae of mosquitoes, is used as a veterinary drug for the treatment of sea lice infestations in Atlantic salmon. Diflubenzuron acts by interference with the synthesis of chitin. It is reported that public exposure to diflubenzuron through either food or drinking-water is negligible.

Approval Year

Targets
PubMed

PubMed

TitleDatePubMed
A method for eradicating amphipod parasites (hyperiidae) from host jellyfish, Chrysaora fuscescens (Brandt, 1835), in a closed recirculating system.
2009-03
Effects of benzoylphenylurea on chitin synthesis and orientation in the cuticle of the Drosophila larva.
2009-03
Resistance to benzoylphenyl urea insecticides in Australian populations of the sheep body louse.
2008-12
Resistance to insect growth regulator insecticides in populations of sheep lice as assessed by a moulting disruption assay.
2008-12
[Simultaneous determination of diflubenzuron and triflumuron residues in greasy wool using high performance liquid chromatography].
2008-11
Response of citrus peelminer Marmara gulosa Guillén and Davis (Lepidoptera: Gracillariidae) stages to various insecticides.
2008-11
Effects of metabolic inhibitors on activity of Cry1Ab toxin to inhibit growth of Ephestia kuehniella larvae.
2008-10
Effectiveness of pyriproxyfen and diflubenzuron formulations as larvicides against Aedes aegypti.
2008-09
Acute effects of diflubenzuron on the freshwater fish Prochilodus lineatus.
2008-09
Molecular phylogeny and population structure of the codling moth (Cydia pomonella) in Central Europe: I. Ancient clade splitting revealed by mitochondrial haplotype markers.
2008-09
Chitinase is stored and secreted from the inner body of microfilariae and has a role in exsheathment in the parasitic nematode Brugia malayi.
2008-09
Determination of photoirradiated high polar benzoylureas in tomato by HPLC with luminol chemiluminescence detection.
2008-08-15
Availability of insecticidal molecules to control Aedes albopictus (Skuse).
2008-06
Chitin in the peritrophic membrane of Acarus siro (Acari: Acaridae) as a target for novel acaricides.
2008-06
Joint effects of density dependence and toxicant exposure on Drosophila melanogaster populations.
2008-06
Variations of plasmid content in Rickettsia felis.
2008-05-28
Transfer of fat-soluble pesticides from contaminated feed to poultry tissues and eggs.
2008-05
Field evaluation of the bioefficacy of diflubenzuron (Dimilin) against container-breeding Aedes sp. mosquitoes.
2008-04
The ecological impact of four IGR insecticides in adults of Hyposoter didymator (Hym., Ichneumonidae): pharmacokinetics approach.
2008-04
Defence mechanisms against insecticides temephos and diflubenzuron in the mosquito Aedes caspius: the P-glycoprotein efflux pumps.
2008-03
Method development for the determination of selected pesticides on tobacco by high-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry.
2008-02-15
Efficacy results of insecticides against Cydia pomonella, the codling moth, in Belgium during the last decade (1998-2007).
2008
Pharmacogenetic and metabolic differences between dog breeds: their impact on canine medicine and the use of the dog as a preclinical animal model.
2008
Comparative studies on effects of three chitin synthesis inhibitors on common malaria mosquito (Diptera: Culicidae).
2007-11
Determination of benzoylurea insecticide residues in tomatoes by high-performance liquid chromatography with ultraviolet-diode array and atmospheric pressure chemical ionization-mass spectrometry detection.
2007-10-25
Insecticidal resistance and cross-resistance in populations of Cydia pomonella (Lepidoptera: Tortricidae) in central Europe.
2007-10
Treatment of natural infestations of the biting louse (Werneckiella equi) on horses using triflumuron, a benzoylurea derivative insect growth regulator.
2007-09-30
Insecticide resistance in potential vector mosquitoes for West Nile virus in Japan.
2007-09
Diversity of insecticide resistance mechanisms and spectrum in European populations of the codling moth, Cydia pomonella.
2007-09
Ovicidal and larvicidal effectiveness of insecticides applied by dipping apples on the small fruit tortrix Grapholita lobarzewskii.
2007-07
A comparative study of micellar and microemulsion EKC for the analysis of benzoylurea insecticides and their analogs.
2007-06
Simulated field evaluation of the efficacy of two formulations of diflubenzuron, a chitin synthesis inhibitor against larvae of Aedes aegypti (L.) (Diptera: Culicidae) in water-storage containers.
2007-03
Synergism between cis-permethrin and benzoyl phenyl urea insect growth regulators against Aedes aegypti larvae.
2007-03
Laboratory evaluation of diflubenzuron as a feed-through for control of immature sand flies (Diptera: Psychodidae).
2007-03
New method for the photo-chemiluminometric determination of benzoylurea insecticides based on acetonitrile chemiluminescence.
2007-03
Great tits (Parus major) reduce caterpillar damage in commercial apple orchards.
2007-02-07
Safety of elevated dosages of a 0.24% diflubenzuron pellet administered orally to horses.
2007
Susceptibility of Aedes aegypti (L) to the insect growth regulators diflubenzuron and methoprene in Uberlândia, State of Minas Gerais.
2006-12-04
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
2006-11
Characterization of a chitin synthase cDNA and its increased mRNA level associated with decreased chitin synthesis in Anopheles quadrimaculatus exposed to diflubenzuron.
2006-09
Fragmentation study and analysis of benzoylurea insecticides and their analogs by liquid chromatography-electrospray ionization-mass spectrometry.
2006-08-15
Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomonella (L.).
2006-08
Hazards and uptake of chitin synthesis inhibitors in bumblebees Bombus terrestris.
2006-08
Efficacy of diflubenzuron, a chitin synthesis inhibitor, against Culex pipiens larvae in septic tank water.
2006-06
Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system.
2006-06
Viewpoint: Policy requirements for protecting wildlife from endocrine disruptors.
2006-04
[An outbreak of Plasmodium vivax malaria in Kyrghyzstan].
2006-03-28
Evaluation of toxicity of two pesticides: flucycloxuron and diflubenzuron on a cellular model, Paramecium sp.
2006
The melon fruit fly, Bactrocera cucurbitae: a review of its biology and management.
2005-12-06
Laboratory and field evaluation of Hilmilin against mosquitoes.
2005-12
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:42:23 GMT 2025
Edited
by admin
on Mon Mar 31 18:42:23 GMT 2025
Record UNII
J76U6ZSI8D
Record Status Validated (UNII)
Record Version
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Name Type Language
DIFLUBENZURON
HSDB   ISO   MART.   MI  
Common Name English
DIFLUBENZURON [HSDB]
Preferred Name English
DIFLUBENZURON [MART.]
Common Name English
1-(4-CHLOROPHENYL)-3-(2,6-DIFLUOROBENZOYL)UREA
Systematic Name English
DIFLUBENZURON [ISO]
Common Name English
DIFLUBENZURON [JAN]
Common Name English
N-(((4-CHLOROPHENYL)AMINO)CARBONYL)-2,6-DIFLUOROBENZAMIDE
Systematic Name English
DIFLUBENZURON [MI]
Common Name English
Classification Tree Code System Code
WHO-VATC QP53BC02
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
EPA PESTICIDE CODE 108201
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
Code System Code Type Description
MESH
D004132
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY
SMS_ID
100000141123
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY
DAILYMED
J76U6ZSI8D
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY
WIKIPEDIA
DIFLUBENZURON
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY
PUBCHEM
37123
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY
EPA CompTox
DTXSID1024049
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY
CHEBI
34703
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY
FDA UNII
J76U6ZSI8D
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY
CAS
35367-38-5
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY
ALANWOOD
diflubenzuron
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY
RXCUI
1665336
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY RxNorm
MERCK INDEX
m4431
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY Merck Index
HSDB
6611
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY
EVMPD
SUB90869
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY
ECHA (EC/EINECS)
252-529-3
Created by admin on Mon Mar 31 18:42:23 GMT 2025 , Edited by admin on Mon Mar 31 18:42:23 GMT 2025
PRIMARY