ZINC

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Zn
Molecular Weight	65.3956
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Zn]

InChI

InChIKey=HCHKCACWOHOZIP-UHFFFAOYSA-N

InChI=1S/Zn

HIDE SMILES / InChI

Molecular Formula	Zn
Molecular Weight	65.3956
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://femsle.oxfordjournals.org/content/femsle/320/1/33.full.pdf
Curator's Comment:: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf

Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
C55-isoprenyl pyrophosphate 7 Target ID: CHEMBL2364036 Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC389626&blobtype=pdf	Binding Agent 996

Conditions

Condition	Modality	Highest Phase	Product
Infection 7 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d827faa-bbbb-4d1d-b806-392b29290c81	Curative	Approved 8043	BACITRACIN Approved Use Uses first aid to help prevent infection in: •minor cuts •scrapes •burns Launch Date -6.7616637E11
Skin diseases 10 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf	Curative	Approved 8043	CORTISPORIN Approved Use For the treatment of corticosteroid-responsice dermatoses with secondary infection. Launch Date -4.0417919E11
Superficial infections of the external eye and its adnexa caused by susceptible bacteria 5 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/50417slr011_neosporin_lbl.pdf	Curative	Approved 8043	NEOSPORIN Approved Use NEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Launch Date -4.7260799E10

PubMed

Title	Date	PubMed
Bacitracin: Methods of Production, Concentration, and Partial Purification, with a Summary of the Chemical Properties of Crude Bacitracin.	1948 Feb	16561454
The relative antisyphilitic activity of penicillins F,G,K, and X and of bacitracin, based on the amounts required to abort early syphilic infections in rabbits.	1948 Mar	18902256
The Action of Bacitracin and Subtilin on Treponema pallidum in Vitro and in Vivo.	1948 Mar	16561465
The Results of the Systemic Administration of the Antibiotic, Bacitracin, in Surgical Infections: A Preliminary Report.	1948 Oct	17859227
A Note on the Susceptibility of Hemophilus influenzae Type B to Bacitracin.	1948 Oct	16561599
The Use of Bacitracin in Experimental Clostridium Welchii Infection in Guinea Pigs.	1949 Oct	17859460
IN VITRO STUDIES ON POSSIBLE SYNERGISTIC ACTION BETWEEN PENICILLIN AND BACITRACIN.	1949 Sep	16695753
In vitro sensitivity of Bacillus proteus and Pseudomonas aeruginosa to seven antibiotics; penicillin, streptomycin, bacitracin, polymyxin, aerosporin, aureomycin, and chloromycetin.	1950 Feb	15404235
Systemic bacitracin in the treatment of progressive bacterial synergistic gangrene.	1950 Feb	15402788
Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity.	1992 Dec	1304235
Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes.	1992 Jul 15	1321133
[Effect of zinc deficiency and zinc replenishment on HOX3.5 gene expression in mouse embryos].	2001 Nov	12561611
Metallothionein is required for zinc-induced expression of the macrophage colony stimulating factor gene.	2002	12112025
p53 protein and p21 mRNA levels and caspase-3 activity are altered by zinc status in aortic endothelial cells.	2002 Aug	12107073
Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells.	2002 Aug	12107072
Isolation of GIF from porcine brain and studies of its zinc transfer kinetics with apo-carbonic anhydrase.	2002 Dec	12405537
Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.	2002 Dec 13	12354775
Purification and characterization of cytosolic glycerol-3-phosphate dehydrogenase from skeletal muscle of jerboa (Jaculus orientalis).	2002 Feb	11952153
S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation.	2002 Jul 2	12081484
Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation.	2002 Jul 5	11983694
Partitioning of accumulated trace metals in the talitrid amphipod crustacean Orchestia gammarellus: a cautionary tale on the use of metallothionein-like proteins as biomarkers.	2002 Jun	11932003
Co-assembly of GABA rho subunits with the GABA(A) receptor gamma(2) subunit cloned from white perch retina.	2002 Jun 30	12106692
White-sided dolphin metallothioneins: purification, characterisation and potential role.	2002 Mar	11912049
Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.	2002 Nov	12429649
Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation.	2002 Nov	12421840
Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activation.	2002 Oct	12389026
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).	2002 Oct 25	12192006
Evidence for non-isostructural replacement of Zn(2+) with Cd(2+) in the beta-domain of brain-specific metallothionein-3.	2002 Sep 11	12220637
Induction of metallothionein by zinc protects from daunorubicin toxicity in rats.	2002 Sep 30	12204545
Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays.	2003 Apr	12672911
Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts.	2003 Aug	12888634
Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.	2003 Aug 1	12888280
Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor.	2003 Aug 15	12915106
Redox labile site in a Zn4 cluster of Cu4,Zn4-metallothionein-3.	2003 Aug 19	12911326
Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.	2003 Dec 5	14506276
Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes.	2003 Feb 15	12566098
The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1alpha is rapidly reversed by zinc repletion.	2003 Jan	12514266
Pancreatic metallothionein-I may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice.	2003 Jan	12514265
p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice.	2003 Jan 1	12517797
A novel class of ligand-gated ion channel is activated by Zn2+.	2003 Jan 10	12381728
Differential effects of zinc on functionally distinct human growth hormone mutations.	2003 Jul	12915731
Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.	2003 Jul 11	12716893
In vitro effect of metal ions on the activity of two amphibian glyceraldehyde-3-phosphate dehydrogenases: potential metal binding sites.	2003 Jun	12798935
Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase.	2003 May 2	12595529
Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process.	2003 Nov 14	12947092
Zinc modulates PPARgamma signaling and activation of porcine endothelial cells.	2003 Oct	14519784
Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family.	2003 Oct 3	12885774
Purification of recombinant human apometallothionein-3 and reconstitution with zinc.	2003 Sep	12963354
Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.	2004 Apr	12972402
Bacitracin Inhibits the Migration of U87-MG Glioma Cells via Interferences of the Integrin Outside-in Signaling Pathway.	2016 Mar	26962415

Patents

Sample Use Guides

In Vivo Use Guide

400 units, topically

Route of Administration: Topical

In Vitro Use Guide

The MIC value was 32 mg/L for Staphylococcus aureus wild type strain after 48h incubation at 37°C.

Substance Class	Chemical Created by `admin` on `Sat Jun 26 12:10:43 UTC 2021` Edited by `admin` on `Sat Jun 26 12:10:43 UTC 2021`
Record UNII	J41CSQ7QDS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZINC	Locators: EMA EPAR II INCI MI VANDF WHO-DD Naming Organization: INCI Sources:

Official Name

English

ZINC, ELEMENTAL

Common Name

English

ZINC, CHELATED

Common Name

English

ZINCUM METALLICUM [HPUS]

Common Name

English

ZINC [II]

Common Name

English

ZINC [VANDF]

Common Name

English

ZN

Code

English

ZINC [INCI]

Common Name

English

ZINC, ELEMENTAL [HSDB]

Common Name

English

ZINC [MI]

Common Name

English

ZINCUM METALLICUM

Common Name

English

ZINC [WHO-DD]

Common Name

English

ZINC [EMA EPAR]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C896