Details
Stereochemistry | ACHIRAL |
Molecular Formula | Zn |
Molecular Weight | 65.409 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Zn]
InChI
InChIKey=HCHKCACWOHOZIP-UHFFFAOYSA-N
InChI=1S/Zn
Molecular Formula | Zn |
Molecular Weight | 65.409 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf
Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2364036 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | BACITRACIN Approved UseUses first aid to help prevent infection in: •minor cuts •scrapes •burns Launch Date1948 |
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Curative | CORTISPORIN Approved UseFor the treatment of corticosteroid-responsice dermatoses with secondary infection. Launch Date1957 |
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Curative | NEOSPORIN Approved UseNEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Launch Date1968 |
PubMed
Title | Date | PubMed |
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Bacitracin: Methods of Production, Concentration, and Partial Purification, with a Summary of the Chemical Properties of Crude Bacitracin. | 1948 Feb |
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The Results of the Systemic Administration of the Antibiotic, Bacitracin, in Surgical Infections: A Preliminary Report. | 1948 Oct |
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IN VITRO STUDIES ON POSSIBLE SYNERGISTIC ACTION BETWEEN PENICILLIN AND BACITRACIN. | 1949 Sep |
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Continuous administration of growth hormone does not prevent the decrease of IGF-I gene expression in zinc-deprived rats despite normalization of liver GH binding. | 1998 Dec |
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Nitric oxide induces Zn2+ release from metallothionein by destroying zinc-sulphur clusters without concomitant formation of S-nitrosothiol. | 1999 Nov 15 |
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Plasma apolipoprotein B-48, hepatic apolipoprotein B mRNA editing and apolipoprotein B mRNA editing catalytic subunit-1 mRNA levels are altered in zinc-deficient rats. | 1999 Oct |
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Copper transport and its defect in Wilson disease: characterization of the copper-binding domain of Wilson disease ATPase. | 2000 Apr |
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The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures. | 2000 Feb 15 |
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Regulation of metallothionein gene expression by oxidative stress and metal ions. | 2000 Jan 1 |
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Reduction of oxidative stress and cytokine-induced neutrophil chemoattractant (CINC) expression by red wine polyphenols in zinc deficiency induced intestinal damage of rat. | 2000 Jun 1 |
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Lead targets GRP78, a molecular chaperone, in C6 rat glioma cells. | 2000 Mar 15 |
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Therapeutic application of zinc in human immunodeficiency virus against opportunistic infections. | 2000 May |
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Effect of the two conserved prolines of human growth inhibitory factor (metallothionein-3) on its biological activity and structure fluctuation: comparison with a mutant protein. | 2000 Nov 28 |
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Increased protein intake during recovery from zinc deficiency is accompanied by alterations in hypothalamic growth hormone releasing factor and somatostatin. | 2001 |
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Dietary zinc deficiency increases uroguanylin accumulation in rat kidney. | 2001 Apr |
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cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes. | 2001 Dec |
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Nitric oxide induces metallothionein (MT) gene expression apparently by displacing zinc bound to MT. | 2001 Feb 28 |
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The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells. | 2001 Jun 22 |
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Cleavage of SNAP-25 by botulinum toxin type A requires receptor-mediated endocytosis, pH-dependent translocation, and zinc. | 2001 Mar |
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p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis. | 2001 May 15 |
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Loss of vesicular zinc and appearance of perikaryal zinc after seizures induced by pilocarpine. | 2001 May 25 |
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A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses. | 2001 Nov |
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Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells. | 2002 Aug |
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Isolation of GIF from porcine brain and studies of its zinc transfer kinetics with apo-carbonic anhydrase. | 2002 Dec |
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Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle. | 2002 Dec 13 |
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Attenuation of both apoptotic and necrotic actions of cadmium by Bcl-2. | 2002 Jan |
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Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone. | 2002 Jan 15 |
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Co-assembly of GABA rho subunits with the GABA(A) receptor gamma(2) subunit cloned from white perch retina. | 2002 Jun 30 |
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Reactive oxygen species modulate Zn(2+)-induced apoptosis in cancer cells. | 2002 Mar 1 |
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Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor. | 2002 May 10 |
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Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents. | 2002 Nov |
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Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation. | 2002 Nov |
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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). | 2002 Oct 25 |
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Induction of metallothionein by zinc protects from daunorubicin toxicity in rats. | 2002 Sep 30 |
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Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform. | 2003 Apr |
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Effect of chromium on apolipoprotein A-I expression in HepG2 cells. | 2003 Apr |
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Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays. | 2003 Apr |
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Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes. | 2003 Feb 15 |
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Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase. | 2003 Feb 4 |
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The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1alpha is rapidly reversed by zinc repletion. | 2003 Jan |
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A novel class of ligand-gated ion channel is activated by Zn2+. | 2003 Jan 10 |
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Differential effects of zinc on functionally distinct human growth hormone mutations. | 2003 Jul |
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Copper reduction by copper binding proteins and its relation to neurodegenerative diseases. | 2003 Mar |
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Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate. | 2003 Oct 3 |
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Thymulin evokes IL-6-C/EBPbeta regenerative repair and TNF-alpha silencing during endotoxin exposure in fetal lung explants. | 2004 Mar |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf
Curator's Comment: Bacitracin can be used as ophtalmic solution (0.025mg/ml) for the treatment of superficial ocular infections.
400 units, topically
Route of Administration:
Topical
Substance Class |
Chemical
Created
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Record UNII |
J41CSQ7QDS
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Record Status |
Validated (UNII)
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NCI_THESAURUS |
C896
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CFR |
21 CFR 101.71
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EMA ASSESSMENT REPORTS |
WILZIN (AUTHOIRIZED: HEPATOLENTICAL DEGENERATION)
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CFR |
21 CFR 176.170
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EPA PESTICIDE CODE |
129015
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NCI_THESAURUS |
C637
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WHO-ATC |
C05AX04
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WHO-ATC |
S01AX03
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CFR |
21 CFR 102.23
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WHO-ATC |
D09AB02
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LIVERTOX |
NBK548211
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DSLD |
137 (Number of products:9660)
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DTXSID7035012
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C948
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SUB130055
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100000092027
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7440-66-6
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231-175-3
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30185
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SUB12619MIG
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D015032
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DB01593
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J41CSQ7QDS
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m11596
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PRIMARY | Merck Index |
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Nutritional value per 100 g (3.5 oz) - 0.41 mg (4%)
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ACTIVE MOIETY |