U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Zn
Molecular Weight 65.409
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZINC

SMILES

[Zn]

InChI

InChIKey=HCHKCACWOHOZIP-UHFFFAOYSA-N
InChI=1S/Zn

HIDE SMILES / InChI

Molecular Formula Zn
Molecular Weight 65.409
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf

Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
BACITRACIN

Approved Use

Uses first aid to help prevent infection in: •minor cuts •scrapes •burns

Launch Date

1948
Curative
CORTISPORIN

Approved Use

For the treatment of corticosteroid-responsice dermatoses with secondary infection.

Launch Date

1957
Curative
NEOSPORIN

Approved Use

NEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis.

Launch Date

1968
PubMed

PubMed

TitleDatePubMed
Bacitracin: Methods of Production, Concentration, and Partial Purification, with a Summary of the Chemical Properties of Crude Bacitracin.
1948 Feb
The Results of the Systemic Administration of the Antibiotic, Bacitracin, in Surgical Infections: A Preliminary Report.
1948 Oct
IN VITRO STUDIES ON POSSIBLE SYNERGISTIC ACTION BETWEEN PENICILLIN AND BACITRACIN.
1949 Sep
Continuous administration of growth hormone does not prevent the decrease of IGF-I gene expression in zinc-deprived rats despite normalization of liver GH binding.
1998 Dec
Nitric oxide induces Zn2+ release from metallothionein by destroying zinc-sulphur clusters without concomitant formation of S-nitrosothiol.
1999 Nov 15
Plasma apolipoprotein B-48, hepatic apolipoprotein B mRNA editing and apolipoprotein B mRNA editing catalytic subunit-1 mRNA levels are altered in zinc-deficient rats.
1999 Oct
Copper transport and its defect in Wilson disease: characterization of the copper-binding domain of Wilson disease ATPase.
2000 Apr
The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
2000 Feb 15
Regulation of metallothionein gene expression by oxidative stress and metal ions.
2000 Jan 1
Reduction of oxidative stress and cytokine-induced neutrophil chemoattractant (CINC) expression by red wine polyphenols in zinc deficiency induced intestinal damage of rat.
2000 Jun 1
Lead targets GRP78, a molecular chaperone, in C6 rat glioma cells.
2000 Mar 15
Therapeutic application of zinc in human immunodeficiency virus against opportunistic infections.
2000 May
Effect of the two conserved prolines of human growth inhibitory factor (metallothionein-3) on its biological activity and structure fluctuation: comparison with a mutant protein.
2000 Nov 28
Increased protein intake during recovery from zinc deficiency is accompanied by alterations in hypothalamic growth hormone releasing factor and somatostatin.
2001
Dietary zinc deficiency increases uroguanylin accumulation in rat kidney.
2001 Apr
cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes.
2001 Dec
Nitric oxide induces metallothionein (MT) gene expression apparently by displacing zinc bound to MT.
2001 Feb 28
The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells.
2001 Jun 22
Cleavage of SNAP-25 by botulinum toxin type A requires receptor-mediated endocytosis, pH-dependent translocation, and zinc.
2001 Mar
p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis.
2001 May 15
Loss of vesicular zinc and appearance of perikaryal zinc after seizures induced by pilocarpine.
2001 May 25
A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses.
2001 Nov
Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells.
2002 Aug
Isolation of GIF from porcine brain and studies of its zinc transfer kinetics with apo-carbonic anhydrase.
2002 Dec
Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.
2002 Dec 13
Attenuation of both apoptotic and necrotic actions of cadmium by Bcl-2.
2002 Jan
Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone.
2002 Jan 15
Co-assembly of GABA rho subunits with the GABA(A) receptor gamma(2) subunit cloned from white perch retina.
2002 Jun 30
Reactive oxygen species modulate Zn(2+)-induced apoptosis in cancer cells.
2002 Mar 1
Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor.
2002 May 10
Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.
2002 Nov
Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation.
2002 Nov
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
2002 Oct 25
Induction of metallothionein by zinc protects from daunorubicin toxicity in rats.
2002 Sep 30
Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform.
2003 Apr
Effect of chromium on apolipoprotein A-I expression in HepG2 cells.
2003 Apr
Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays.
2003 Apr
Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes.
2003 Feb 15
Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase.
2003 Feb 4
The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1alpha is rapidly reversed by zinc repletion.
2003 Jan
A novel class of ligand-gated ion channel is activated by Zn2+.
2003 Jan 10
Differential effects of zinc on functionally distinct human growth hormone mutations.
2003 Jul
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.
2003 Mar
Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.
2003 Oct 3
Thymulin evokes IL-6-C/EBPbeta regenerative repair and TNF-alpha silencing during endotoxin exposure in fetal lung explants.
2004 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Bacitracin can be used as ophtalmic solution (0.025mg/ml) for the treatment of superficial ocular infections.
400 units, topically
Route of Administration: Topical
The MIC value was 32 mg/L for Staphylococcus aureus wild type strain after 48h incubation at 37°C.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:38:24 GMT 2023
Edited
by admin
on Fri Dec 15 15:38:24 GMT 2023
Record UNII
J41CSQ7QDS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZINC
EMA EPAR   II   INCI   MI   VANDF   WHO-DD  
INCI  
Official Name English
ZINC, ELEMENTAL
HSDB  
Common Name English
ZINC, CHELATED
Common Name English
ZINCUM METALLICUM [HPUS]
Common Name English
ZINC [II]
Common Name English
ZINC [VANDF]
Common Name English
Zinc [WHO-DD]
Common Name English
ZN
Code English
ZINC [INCI]
Common Name English
ZINC, ELEMENTAL [HSDB]
Common Name English
ZINC [MI]
Common Name English
ZINCUM METALLICUM
HPUS  
Common Name English
ZINC [EMA EPAR]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C896
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
CFR 21 CFR 101.71
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
EMA ASSESSMENT REPORTS WILZIN (AUTHOIRIZED: HEPATOLENTICAL DEGENERATION)
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
CFR 21 CFR 176.170
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
EPA PESTICIDE CODE 129015
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
NCI_THESAURUS C637
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
WHO-ATC C05AX04
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
WHO-ATC S01AX03
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
CFR 21 CFR 102.23
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
WHO-ATC D09AB02
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
LIVERTOX NBK548211
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
DSLD 137 (Number of products:9660)
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID7035012
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
NCI_THESAURUS
C948
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
PUBCHEM
23994
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
HSDB
1344
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
EVMPD
SUB130055
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
ALTERNATIVE
CHEBI
27363
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
SMS_ID
100000092027
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
CAS
7440-66-6
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
ECHA (EC/EINECS)
231-175-3
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
CHEBI
30185
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
DAILYMED
J41CSQ7QDS
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
RXCUI
11416
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
EVMPD
SUB12619MIG
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
MESH
D015032
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
DRUG BANK
DB01593
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
RXCUI
253210
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
ALTERNATIVE
FDA UNII
J41CSQ7QDS
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY
MERCK INDEX
m11596
Created by admin on Fri Dec 15 15:38:24 GMT 2023 , Edited by admin on Fri Dec 15 15:38:24 GMT 2023
PRIMARY Merck Index
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
Nutritional value per 100 g (3.5 oz) - 0.41 mg (4%)
Related Record Type Details
ACTIVE MOIETY