Details
Stereochemistry | ACHIRAL |
Molecular Formula | Zn |
Molecular Weight | 65.409 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Zn]
InChI
InChIKey=HCHKCACWOHOZIP-UHFFFAOYSA-N
InChI=1S/Zn
Molecular Formula | Zn |
Molecular Weight | 65.409 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf
Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2364036 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | BACITRACIN Approved UseUses first aid to help prevent infection in: •minor cuts •scrapes •burns Launch Date-6.7616637E11 |
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Curative | CORTISPORIN Approved UseFor the treatment of corticosteroid-responsice dermatoses with secondary infection. Launch Date-4.0417919E11 |
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Curative | NEOSPORIN Approved UseNEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Launch Date-4.7260799E10 |
PubMed
Title | Date | PubMed |
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Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity. | 1992 Dec |
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Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes. | 1992 Jul 15 |
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Increased protein intake during recovery from zinc deficiency is accompanied by alterations in hypothalamic growth hormone releasing factor and somatostatin. | 2001 |
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Influence of dietary zinc deficiency during development on hepatic CYP2C11, CYP2C12, CYP3A2, CYP3A9, and CYP3A18 expression in postpubertal male rats. | 2001 Nov 1 |
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Metallothionein is required for zinc-induced expression of the macrophage colony stimulating factor gene. | 2002 |
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p53 protein and p21 mRNA levels and caspase-3 activity are altered by zinc status in aortic endothelial cells. | 2002 Aug |
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Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells. | 2002 Aug |
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Isolation of GIF from porcine brain and studies of its zinc transfer kinetics with apo-carbonic anhydrase. | 2002 Dec |
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Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle. | 2002 Dec 13 |
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Attenuation of both apoptotic and necrotic actions of cadmium by Bcl-2. | 2002 Jan |
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Allosteric modulation of beta2-adrenergic receptor by Zn(2+). | 2002 Jan |
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Role of a copper-specific metallothionein of the blue crab, Callinectes sapidus, in copper metabolism associated with degradation and synthesis of hemocyanin. | 2002 Jan 15 |
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Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone. | 2002 Jan 15 |
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White-sided dolphin metallothioneins: purification, characterisation and potential role. | 2002 Mar |
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Reactive oxygen species modulate Zn(2+)-induced apoptosis in cancer cells. | 2002 Mar 1 |
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Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. | 2002 May 24 |
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Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activation. | 2002 Oct |
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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). | 2002 Oct 25 |
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Evidence for non-isostructural replacement of Zn(2+) with Cd(2+) in the beta-domain of brain-specific metallothionein-3. | 2002 Sep 11 |
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Induction of metallothionein by zinc protects from daunorubicin toxicity in rats. | 2002 Sep 30 |
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Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform. | 2003 Apr |
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Effect of chromium on apolipoprotein A-I expression in HepG2 cells. | 2003 Apr |
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Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays. | 2003 Apr |
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Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. | 2003 Aug |
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Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells. | 2003 Aug 1 |
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Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor. | 2003 Aug 15 |
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Redox labile site in a Zn4 cluster of Cu4,Zn4-metallothionein-3. | 2003 Aug 19 |
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The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice. | 2003 Aug 29 |
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Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. | 2003 Dec 5 |
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Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes. | 2003 Feb 15 |
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Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase. | 2003 Feb 4 |
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Activation of the rainbow trout metallothionein-A promoter by silver and zinc. | 2003 Jan |
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Pancreatic metallothionein-I may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice. | 2003 Jan |
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A novel class of ligand-gated ion channel is activated by Zn2+. | 2003 Jan 10 |
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Differential effects of zinc on functionally distinct human growth hormone mutations. | 2003 Jul |
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Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1. | 2003 Jul 11 |
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In vitro effect of metal ions on the activity of two amphibian glyceraldehyde-3-phosphate dehydrogenases: potential metal binding sites. | 2003 Jun |
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Zinc accumulation in N-methyl-N-nitrosourea-induced rat mammary tumors is accompanied by an altered expression of ZnT-1 and metallothionein. | 2003 Jun |
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Copper reduction by copper binding proteins and its relation to neurodegenerative diseases. | 2003 Mar |
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Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase. | 2003 May 2 |
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Zinc modulates mRNA levels of cytokines. | 2003 Nov |
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Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process. | 2003 Nov 14 |
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Zinc modulates PPARgamma signaling and activation of porcine endothelial cells. | 2003 Oct |
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Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters. | 2003 Oct 1 |
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Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. | 2003 Oct 3 |
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Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate. | 2003 Oct 3 |
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Purification of recombinant human apometallothionein-3 and reconstitution with zinc. | 2003 Sep |
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O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145. | 2003 Sep 23 |
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Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation. | 2004 Apr |
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Thymulin evokes IL-6-C/EBPbeta regenerative repair and TNF-alpha silencing during endotoxin exposure in fetal lung explants. | 2004 Mar |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf
Curator's Comment: Bacitracin can be used as ophtalmic solution (0.025mg/ml) for the treatment of superficial ocular infections.
400 units, topically
Route of Administration:
Topical
Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Jul 05 23:07:37 UTC 2023
by
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on
Wed Jul 05 23:07:37 UTC 2023
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Record UNII |
J41CSQ7QDS
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Record Status |
Validated (UNII)
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NCI_THESAURUS |
C896
Created by
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CFR |
21 CFR 101.71
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EMA ASSESSMENT REPORTS |
WILZIN (AUTHOIRIZED: HEPATOLENTICAL DEGENERATION)
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CFR |
21 CFR 176.170
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EPA PESTICIDE CODE |
129015
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NCI_THESAURUS |
C637
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WHO-ATC |
C05AX04
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WHO-ATC |
S01AX03
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CFR |
21 CFR 102.23
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WHO-ATC |
D09AB02
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LIVERTOX |
NBK548211
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DSLD |
137 (Number of products:9660)
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DTXSID7035012
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C948
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SUB130055
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27363
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100000092027
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7440-66-6
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231-175-3
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30185
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J41CSQ7QDS
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SUB12619MIG
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D015032
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DB01593
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253210
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J41CSQ7QDS
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M11596
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PRIMARY | Merck Index |
Related Record | Type | Details | ||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Nutritional value per 100 g (3.5 oz) - 0.41 mg (4%)
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Related Record | Type | Details | ||
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ACTIVE MOIETY |