ZINC

US Approved OTC

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Zn
Molecular Weight	65.409
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Zn]

InChI

InChIKey=HCHKCACWOHOZIP-UHFFFAOYSA-N

InChI=1S/Zn

HIDE SMILES / InChI

Molecular Formula	Zn
Molecular Weight	65.409
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://femsle.oxfordjournals.org/content/femsle/320/1/33.full.pdf
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf

Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
C55-isoprenyl pyrophosphate 7 Target ID: CHEMBL2364036 Sources: http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC389626&blobtype=pdf	Binding Agent 1059

Conditions

Condition	Modality	Highest Phase	Product
Infection 7 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6d827faa-bbbb-4d1d-b806-392b29290c81	Curative	Approved 8360	BACITRACIN Approved Use Uses first aid to help prevent infection in: •minor cuts •scrapes •burns Launch Date -6.7616637E11
Skin diseases 10 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf	Curative	Approved 8360	CORTISPORIN Approved Use For the treatment of corticosteroid-responsice dermatoses with secondary infection. Launch Date -4.0417919E11
Superficial infections of the external eye and its adnexa caused by susceptible bacteria 5 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/50417slr011_neosporin_lbl.pdf	Curative	Approved 8360	NEOSPORIN Approved Use NEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Launch Date -4.7260799E10

PubMed

Title	Date	PubMed
Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity.	1992 Dec	1304235
Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes.	1992 Jul 15	1321133
Increased protein intake during recovery from zinc deficiency is accompanied by alterations in hypothalamic growth hormone releasing factor and somatostatin.	2001	11842894
Influence of dietary zinc deficiency during development on hepatic CYP2C11, CYP2C12, CYP3A2, CYP3A9, and CYP3A18 expression in postpubertal male rats.	2001 Nov 1	11705462
Metallothionein is required for zinc-induced expression of the macrophage colony stimulating factor gene.	2002	12112025
p53 protein and p21 mRNA levels and caspase-3 activity are altered by zinc status in aortic endothelial cells.	2002 Aug	12107073
Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells.	2002 Aug	12107072
Isolation of GIF from porcine brain and studies of its zinc transfer kinetics with apo-carbonic anhydrase.	2002 Dec	12405537
Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.	2002 Dec 13	12354775
Attenuation of both apoptotic and necrotic actions of cadmium by Bcl-2.	2002 Jan	11781163
Allosteric modulation of beta2-adrenergic receptor by Zn(2+).	2002 Jan	11752207
Role of a copper-specific metallothionein of the blue crab, Callinectes sapidus, in copper metabolism associated with degradation and synthesis of hemocyanin.	2002 Jan 15	11803044
Reduction of copper and metallothionein in toxic milk mice by tetrathiomolybdate, but not deferiprone.	2002 Jan 15	11803042
White-sided dolphin metallothioneins: purification, characterisation and potential role.	2002 Mar	11912049
Reactive oxygen species modulate Zn(2+)-induced apoptosis in cancer cells.	2002 Mar 1	11864783
Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells.	2002 May 24	11904301
Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activation.	2002 Oct	12389026
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).	2002 Oct 25	12192006
Evidence for non-isostructural replacement of Zn(2+) with Cd(2+) in the beta-domain of brain-specific metallothionein-3.	2002 Sep 11	12220637
Induction of metallothionein by zinc protects from daunorubicin toxicity in rats.	2002 Sep 30	12204545
Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform.	2003 Apr	12714242
Effect of chromium on apolipoprotein A-I expression in HepG2 cells.	2003 Apr	12679171
Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays.	2003 Apr	12672911
Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts.	2003 Aug	12888634
Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.	2003 Aug 1	12888280
Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor.	2003 Aug 15	12915106
Redox labile site in a Zn4 cluster of Cu4,Zn4-metallothionein-3.	2003 Aug 19	12911326
The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice.	2003 Aug 29	12801924
Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.	2003 Dec 5	14506276
Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes.	2003 Feb 15	12566098
Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase.	2003 Feb 4	12549918
Activation of the rainbow trout metallothionein-A promoter by silver and zinc.	2003 Jan	12524046
Pancreatic metallothionein-I may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice.	2003 Jan	12514265
A novel class of ligand-gated ion channel is activated by Zn2+.	2003 Jan 10	12381728
Differential effects of zinc on functionally distinct human growth hormone mutations.	2003 Jul	12915731
Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.	2003 Jul 11	12716893
In vitro effect of metal ions on the activity of two amphibian glyceraldehyde-3-phosphate dehydrogenases: potential metal binding sites.	2003 Jun	12798935
Zinc accumulation in N-methyl-N-nitrosourea-induced rat mammary tumors is accompanied by an altered expression of ZnT-1 and metallothionein.	2003 Jun	12773700
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.	2003 Mar	12572668
Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase.	2003 May 2	12595529
Zinc modulates mRNA levels of cytokines.	2003 Nov	12812920
Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process.	2003 Nov 14	12947092
Zinc modulates PPARgamma signaling and activation of porcine endothelial cells.	2003 Oct	14519784
Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.	2003 Oct 1	12839489
Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family.	2003 Oct 3	12885774
Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.	2003 Oct 3	12732622
Purification of recombinant human apometallothionein-3 and reconstitution with zinc.	2003 Sep	12963354
O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.	2003 Sep 23	12974631
Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.	2004 Apr	12972402
Thymulin evokes IL-6-C/EBPbeta regenerative repair and TNF-alpha silencing during endotoxin exposure in fetal lung explants.	2004 Mar	12639846

Patents

Sample Use Guides

In Vivo Use Guide

400 units, topically

Route of Administration: Topical

In Vitro Use Guide

The MIC value was 32 mg/L for Staphylococcus aureus wild type strain after 48h incubation at 37°C.

Substance Class	Chemical Created by `admin` on `Wed Jul 05 23:07:37 UTC 2023` Edited by `admin` on `Wed Jul 05 23:07:37 UTC 2023`
Record UNII	J41CSQ7QDS
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ZINC	Locators: EMA EPAR II INCI MI VANDF WHO-DD Naming Organization: INCI Sources:

Official Name

English

ZINC, ELEMENTAL

Common Name

English

ZINC, CHELATED

Common Name

English

ZINCUM METALLICUM [HPUS]

Common Name

English

ZINC [II]

Common Name

English

ZINC [VANDF]

Common Name

English

Zinc [WHO-DD]

Common Name

English

ZN

Code

English

ZINC [INCI]

Common Name

English

ZINC, ELEMENTAL [HSDB]

Common Name

English

ZINC [MI]

Common Name

English

ZINCUM METALLICUM

Common Name

English

ZINC [EMA EPAR]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C896