U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Zn
Molecular Weight 65.3956
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZINC

SMILES

[Zn]

InChI

InChIKey=HCHKCACWOHOZIP-UHFFFAOYSA-N
InChI=1S/Zn

HIDE SMILES / InChI

Molecular Formula Zn
Molecular Weight 65.3956
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50168slr078_cotisporin_lbl.pdf

Bacitracin is a polypeptide antibiotic produced by Bacillus subtilis and Bacillus licheniformis. Bacitracin in combination with neomycin and polymyxin B is indicated for the treatment of many bacterial diseases. The antibacterial properties of bacitracin are mediated by its binding to C55-isoprenyl pyrophosphate, resulting in inhibition of cell wall biosynthesis.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
BACITRACIN

Approved Use

Uses first aid to help prevent infection in: •minor cuts •scrapes •burns

Launch Date

-6.7616637E11
Curative
CORTISPORIN

Approved Use

For the treatment of corticosteroid-responsice dermatoses with secondary infection.

Launch Date

-4.0417919E11
Curative
NEOSPORIN

Approved Use

NEOSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis.

Launch Date

-4.7260799E10
PubMed

PubMed

TitleDatePubMed
Bacitracin: Methods of Production, Concentration, and Partial Purification, with a Summary of the Chemical Properties of Crude Bacitracin.
1948 Feb
The relative antisyphilitic activity of penicillins F,G,K, and X and of bacitracin, based on the amounts required to abort early syphilic infections in rabbits.
1948 Mar
The Action of Bacitracin and Subtilin on Treponema pallidum in Vitro and in Vivo.
1948 Mar
The Results of the Systemic Administration of the Antibiotic, Bacitracin, in Surgical Infections: A Preliminary Report.
1948 Oct
A Note on the Susceptibility of Hemophilus influenzae Type B to Bacitracin.
1948 Oct
The Use of Bacitracin in Experimental Clostridium Welchii Infection in Guinea Pigs.
1949 Oct
IN VITRO STUDIES ON POSSIBLE SYNERGISTIC ACTION BETWEEN PENICILLIN AND BACITRACIN.
1949 Sep
In vitro sensitivity of Bacillus proteus and Pseudomonas aeruginosa to seven antibiotics; penicillin, streptomycin, bacitracin, polymyxin, aerosporin, aureomycin, and chloromycetin.
1950 Feb
Systemic bacitracin in the treatment of progressive bacterial synergistic gangrene.
1950 Feb
Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity.
1992 Dec
Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes.
1992 Jul 15
[Effect of zinc deficiency and zinc replenishment on HOX3.5 gene expression in mouse embryos].
2001 Nov
Metallothionein is required for zinc-induced expression of the macrophage colony stimulating factor gene.
2002
p53 protein and p21 mRNA levels and caspase-3 activity are altered by zinc status in aortic endothelial cells.
2002 Aug
Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cells.
2002 Aug
Isolation of GIF from porcine brain and studies of its zinc transfer kinetics with apo-carbonic anhydrase.
2002 Dec
Zinc-dependent interaction between dishevelled and the Drosophila Wnt antagonist naked cuticle.
2002 Dec 13
Purification and characterization of cytosolic glycerol-3-phosphate dehydrogenase from skeletal muscle of jerboa (Jaculus orientalis).
2002 Feb
S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation.
2002 Jul 2
Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation.
2002 Jul 5
Partitioning of accumulated trace metals in the talitrid amphipod crustacean Orchestia gammarellus: a cautionary tale on the use of metallothionein-like proteins as biomarkers.
2002 Jun
Co-assembly of GABA rho subunits with the GABA(A) receptor gamma(2) subunit cloned from white perch retina.
2002 Jun 30
White-sided dolphin metallothioneins: purification, characterisation and potential role.
2002 Mar
Zinc inhibits nuclear factor-kappa B activation and sensitizes prostate cancer cells to cytotoxic agents.
2002 Nov
Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation.
2002 Nov
Zinc enhances the expression of interleukin-2 and interleukin-2 receptors in HUT-78 cells by way of NF-kappaB activation.
2002 Oct
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
2002 Oct 25
Evidence for non-isostructural replacement of Zn(2+) with Cd(2+) in the beta-domain of brain-specific metallothionein-3.
2002 Sep 11
Induction of metallothionein by zinc protects from daunorubicin toxicity in rats.
2002 Sep 30
Changes in rat hepatic gene expression in response to zinc deficiency as assessed by DNA arrays.
2003 Apr
Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts.
2003 Aug
Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.
2003 Aug 1
Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor.
2003 Aug 15
Redox labile site in a Zn4 cluster of Cu4,Zn4-metallothionein-3.
2003 Aug 19
Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.
2003 Dec 5
Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes.
2003 Feb 15
The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1alpha is rapidly reversed by zinc repletion.
2003 Jan
Pancreatic metallothionein-I may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice.
2003 Jan
p53 deficiency accelerates induction and progression of esophageal and forestomach tumors in zinc-deficient mice.
2003 Jan 1
A novel class of ligand-gated ion channel is activated by Zn2+.
2003 Jan 10
Differential effects of zinc on functionally distinct human growth hormone mutations.
2003 Jul
Chromium(VI) down-regulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor, metal-responsive transcription factor 1.
2003 Jul 11
In vitro effect of metal ions on the activity of two amphibian glyceraldehyde-3-phosphate dehydrogenases: potential metal binding sites.
2003 Jun
Interaction of Tl+ with product complexes of fructose-1,6-bisphosphatase.
2003 May 2
Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process.
2003 Nov 14
Zinc modulates PPARgamma signaling and activation of porcine endothelial cells.
2003 Oct
Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family.
2003 Oct 3
Purification of recombinant human apometallothionein-3 and reconstitution with zinc.
2003 Sep
Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.
2004 Apr
Bacitracin Inhibits the Migration of U87-MG Glioma Cells via Interferences of the Integrin Outside-in Signaling Pathway.
2016 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment:: Bacitracin can be used as ophtalmic solution (0.025mg/ml) for the treatment of superficial ocular infections.
400 units, topically
Route of Administration: Topical
The MIC value was 32 mg/L for Staphylococcus aureus wild type strain after 48h incubation at 37°C.
Substance Class Chemical
Created
by admin
on Sat Jun 26 12:10:43 UTC 2021
Edited
by admin
on Sat Jun 26 12:10:43 UTC 2021
Record UNII
J41CSQ7QDS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZINC
EMA EPAR   II   INCI   MI   VANDF   WHO-DD  
INCI  
Official Name English
ZINC, ELEMENTAL
HSDB  
Common Name English
ZINC, CHELATED
Common Name English
ZINCUM METALLICUM [HPUS]
Common Name English
ZINC [II]
Common Name English
ZINC [VANDF]
Common Name English
ZN
Code English
ZINC [INCI]
Common Name English
ZINC, ELEMENTAL [HSDB]
Common Name English
ZINC [MI]
Common Name English
ZINCUM METALLICUM
HPUS  
Common Name English
ZINC [WHO-DD]
Common Name English
ZINC [EMA EPAR]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C896
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
CFR 21 CFR 101.71
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
EMA ASSESSMENT REPORTS WILZIN (AUTHOIRIZED: HEPATOLENTICAL DEGENERATION)
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
CFR 21 CFR 176.170
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
EPA PESTICIDE CODE 129015
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
NCI_THESAURUS C637
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
WHO-ATC C05AX04
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
WHO-ATC S01AX03
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
CFR 21 CFR 102.23
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
WHO-ATC D09AB02
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
LIVERTOX 1049
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
DSLD 137 (Number of products:9660)
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
Code System Code Type Description
EPA CompTox
7440-66-6
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
PRIMARY
NCI_THESAURUS
C948
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
PRIMARY
PUBCHEM
23994
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
PRIMARY
HSDB
1344
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
PRIMARY
EVMPD
SUB130055
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
ALTERNATIVE
CAS
7440-66-6
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
PRIMARY
ECHA (EC/EINECS)
231-175-3
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
PRIMARY
RXCUI
11416
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
PRIMARY
EVMPD
SUB12619MIG
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
PRIMARY
MESH
D015032
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
PRIMARY
DRUG BANK
DB01593
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
PRIMARY
RXCUI
253210
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
ALTERNATIVE
FDA UNII
J41CSQ7QDS
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
PRIMARY
MERCK INDEX
M11596
Created by admin on Sat Jun 26 12:10:43 UTC 2021 , Edited by admin on Sat Jun 26 12:10:43 UTC 2021
PRIMARY Merck Index
Related Record Type Details
PARENT -> CONSTITUENT ALWAYS PRESENT
Nutritional value per 100 g (3.5 oz) - 0.41 mg (4%)
Related Record Type Details
ACTIVE MOIETY