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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 16:21:30 GMT 2025
Edited
by admin
on Wed Apr 02 16:21:30 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG4
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
J38KT46AH8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Narlumosbart
INN  
Official Name English
Immunoglobulin G4 [230-proline], anti-(human osteoclast differentiation factor) (human monoclonal JMT103 ?4-chain), disulfide with human monoclonal JMT103 ?-chain, dimer
Preferred Name English
gamma4 heavy chain Homo sapiens (1-449) [VH(Homo sapiens IGHV3-23*01 (98.0%)-(IGHD)-IGHJ5*02 (93.8%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122)-Homo sapiens IGHG4*01, G4v5 hP10, nG4m(a) CH2 L92 (CH1(123-220), hinge 1-12, S10>P(230) (221-232), CH2 L
Common Name English
immunoglobulin G4-kappa, anti-[TNFSF11 (tumor necrosis factor (TNF) superfamily member 11, osteoclast differentiation factor, ODF, OPGL, RANKL, TRANCE, CD254)], Homo sapiens monoclonal antibody
Common Name English
Narlumosbart [WHO-DD]
Common Name English
narlumosbart [INN]
Common Name English
Code System Code Type Description
CAS
2646587-68-8
Created by admin on Wed Apr 02 16:21:30 GMT 2025 , Edited by admin on Wed Apr 02 16:21:30 GMT 2025
PRIMARY
SMS_ID
300000046859
Created by admin on Wed Apr 02 16:21:30 GMT 2025 , Edited by admin on Wed Apr 02 16:21:30 GMT 2025
PRIMARY
FDA UNII
J38KT46AH8
Created by admin on Wed Apr 02 16:21:30 GMT 2025 , Edited by admin on Wed Apr 02 16:21:30 GMT 2025
PRIMARY
INN
12344
Created by admin on Wed Apr 02 16:21:30 GMT 2025 , Edited by admin on Wed Apr 02 16:21:30 GMT 2025
PRIMARY
NCI_THESAURUS
C190458
Created by admin on Wed Apr 02 16:21:30 GMT 2025 , Edited by admin on Wed Apr 02 16:21:30 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_136 4_215
2_149 2_205
2_263 2_323
1_136 3_215
2_369 2_427
3_23 3_89
3_135 3_195
4_23 4_89
4_135 4_195
1_149 1_205
1_228 2_228
1_231 2_231
1_263 1_323
1_369 1_427
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_299
N 2_299
Related Record Type Details
Narlumosbart
ACTIVE MOIETY
anti-[TNFSF11 (tumor necrosis factor (TNF) superfamily member 11

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID REMOVAL [1_449] [2_449] SITE_SPECIFIC LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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