U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 15:42:26 GMT 2023
Edited
by admin
on Sat Dec 16 15:42:26 GMT 2023
Nucleic Acid Type OLIGONUCLEOTIDE
Nucleic Acid Subtype ANTI-SENSE
Sequence Type COMPLETE
Record UNII
J2Y9QT3BWL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FRENLOSIRSEN
USAN   INN  
Official Name English
ION-251 FREE ACID
Code English
DNA, D(P-THIO)((2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)-.ALPHA.-L-MANNOFURANO)A-(3'->4')-(2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)-.ALPHA.-L-MANNOFURANO)G-T-T-G-T-A-A-A-T-G-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL)
Systematic Name English
ION251 FREE ACID
Code English
frenlosirsen [INN]
Common Name English
ALL-P-AMBO-2'-O,4'-C-((S)-ETHYLIDENE)-P-THIOADENYLYL-(3'-O->5-O)-2'-O,4'-C-((S)-ETHYLIDENE)-P-THIOGUANYLYL-(3'-O->5'-O)-P-THIOTHYMIDYLYL-(3'-O->5'-O)-P-THIOTHYMIDYLYL-(3'-O->5'-O)-2'-DEOXY-P-THIOGUANYLYL-(3'-O->5'-O)-P-THIOTHYMIDYLYL-(3'-O->5'-O)-2'-DEOX
Systematic Name English
FRENLOSIRSEN [USAN]
Common Name English
ION-935918 FREE ACID
Code English
Code System Code Type Description
CAS
2304711-81-5
Created by admin on Sat Dec 16 15:42:27 GMT 2023 , Edited by admin on Sat Dec 16 15:42:27 GMT 2023
PRIMARY
USAN
HI-04
Created by admin on Sat Dec 16 15:42:27 GMT 2023 , Edited by admin on Sat Dec 16 15:42:27 GMT 2023
PRIMARY
NCI_THESAURUS
C173725
Created by admin on Sat Dec 16 15:42:27 GMT 2023 , Edited by admin on Sat Dec 16 15:42:27 GMT 2023
PRIMARY
FDA UNII
J2Y9QT3BWL
Created by admin on Sat Dec 16 15:42:27 GMT 2023 , Edited by admin on Sat Dec 16 15:42:27 GMT 2023
PRIMARY
INN
11520
Created by admin on Sat Dec 16 15:42:27 GMT 2023 , Edited by admin on Sat Dec 16 15:42:27 GMT 2023
PRIMARY
Sugar Site Range Site Count
1_1-1_2;1_15-1_16 4 / 16
Deoxyribose (DNA) 1_3-1_11 9 / 16
2'-O-Methoxyethyl ribose 1_12-1_14 3 / 16
Linkage Site Range Site Count
Phosporothioate 1_2-1_16 15 / 15
Related Record Type Details
ACTIVE MOIETY