AMOPROXAN HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H35NO7.ClH
Molecular Weight	461.977
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC(=CC(OC)=C1OC)C(=O)OC(COCCC(C)C)CN2CCOCC2

InChI

InChIKey=HKTUGQIHGLSWGU-UHFFFAOYSA-N

InChI=1S/C22H35NO7.ClH/c1-16(2)6-9-29-15-18(14-23-7-10-28-11-8-23)30-22(24)17-12-19(25-3)21(27-5)20(13-17)26-4;/h12-13,16,18H,6-11,14-15H2,1-5H3;1H

HIDE SMILES / InChI

Molecular Formula	C22H35NO7
Molecular Weight	425.5158
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://books.google.ru/books?id=_J2ti4EkYpkC&pg=PA292&dq=AMOPROXAN retrieved from Pharmaceutical Manufacturing Encyclopedia William Andrew Publishing, p.292
Curator's Comment: https://books.google.ru/books?id=mDLYCQAAQBAJ&pg=PA135&lpg=PA135&dq=AMOPROXAN retrieved from Toxicology of the Eye: Effects on the Eyes and Visual System from Chemicals, Drugs, Metals and Minerals, Plants, Toxins, and Venoms; Also, Systemic Side Effects from Eye med (2-Volume Set), p.135

Amoproxan (Mederel, Mexderel), a coronary artery dilator and anti-arrhythmic, apparently withdrawn from production, produced pellagroid skin changes and several cases of axial optic neuropathy in France.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Angina pectoris 106 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5437771	Primary		Withdrawn	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Dermatitis of uncovered parts in 6 patients taking amoproxan (Mederel)].	1970	4250788

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:12:52 GMT 2023` Edited by `admin` on `Fri Dec 15 19:12:52 GMT 2023`
Record UNII	J28W7C2OPN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMOPROXAN HYDROCHLORIDE

Common Name

English

4-(3-ISOAMYLOXY-2-(3,4,5-TRIMETHOXYBENZOYLOXY)PROPYL)TETRAHYDRO-1,4-OXAZINE HYDROCHLORIDE

Systematic Name

English

AMOPROXAN HYDROCHLORIDE [MI]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID40945325