Sonefpeglutide

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 08:11:28 GMT 2025` Edited by `admin` on `Wed Apr 02 08:11:28 GMT 2025`
Protein Type	FC FUSION PROTEIN
Protein Sub Type	GLUCAGON-LIKE PEPTIDE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	J28M3X94LD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Sonefpeglutide

Official Name

English

2-33-Glucagon-like peptide II [2-[N-[2-(1H-imidazol-4-yl)acetyl]glycine],30-L-arginine,33a-[N<sup>6</sup>-(3-hydroxypropyl)-L-lysine]] (human), 33a-ether with ?-hydro-?-hydroxypoly(oxy-1,2-ethanediyl), (33a?1) ether with immunoglobulin G4 [1-[1-(3-hydrox

Preferred Name

English

glucagon-like peptide 2 (GLP-2) analogue, conjugated through a 3.4 kDa polyethylene glycol (PEG) linker (n ~ 75) to an Fc portion dimer of human immunoglobulin G4 (IgG4)

Common Name

English

sonefpeglutide [INN]

Common Name

English

N<sup>1.1</sup>-(3-{?-[3-({[Ala<sup>2</sup>>N-[(1H-imidazol-4-yl)acetyl]Gly1,Lys<sup>30</sup>>Arg<sup>29</sup>]glucagon like peptide 2 (2-33)-peptidyl (1-32)-L-lysine (33)}-N<sup>6.33</sup>-yl)propyl]poly(oxyethylene(3.4 kDa))-?-oxy}propyl)[immunoglobuli

Common Name

English

Code System Code Type Description

INN

13024

Created by admin on Wed Apr 02 08:11:28 GMT 2025 , Edited by admin on Wed Apr 02 08:11:28 GMT 2025

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FDA UNII

J28M3X94LD

Created by admin on Wed Apr 02 08:11:28 GMT 2025 , Edited by admin on Wed Apr 02 08:11:28 GMT 2025

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SMS_ID

300000056152

Created by admin on Wed Apr 02 08:11:28 GMT 2025 , Edited by admin on Wed Apr 02 08:11:28 GMT 2025

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CAS

2854391-99-2

Created by admin on Wed Apr 02 08:11:28 GMT 2025 , Edited by admin on Wed Apr 02 08:11:28 GMT 2025

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NCI_THESAURUS

C206991

Created by admin on Wed Apr 02 08:11:28 GMT 2025 , Edited by admin on Wed Apr 02 08:11:28 GMT 2025

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From	To
1_3	2_3
1_35	1_95
1_141	1_199
2_35	2_95
2_35	2_95

Linkage Type	Residue Index
PROLINE-PEG-3400-LYSINE	1_1	3_33

Glycosylation Link Type	Site
N	1_71
N	2_71

Related Record Type Details


					I22705MV2H

GLUCAGON-LIKE PEPTIDE 2 RECEPTOR

TARGET -> AGONIST

Amount:

Related Record Type Details


					J28M3X94LD

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[3_33]	C-TERMINUS			UNSPECIFIED SUBSTANCE	973097a1 (not in database)
AMINO_ACID_SUBSTITUTION	[1_1]	N-TERMINUS			UNSPECIFIED SUBSTANCE	973097a1 (not in database)
AMINO_ACID_SUBSTITUTION	[3_1]	N-TERMINUS			GLYCINE, N-(1H-IMIDAZOL-4-YLCARBONYL)-	RYH25GTU8O

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL