LOTILIBCIN HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C73H111N17O21.2ClH
Molecular Weight	1635.6884
Optical Activity	UNSPECIFIED
Defined Stereocenters	13 / 13
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.[H][C@@]1(NC(=O)[C@H](CO)NC(=O)C[C@@H](CCCC(C)C)OC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](CCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC4=CC=CC=C4)N(C)C(=O)CNC(=O)[C@H](CO)NC1=O)[C@@H](O)C(N)=O

InChI

InChIKey=VBXUDTFBJRKXBU-JCBBIFMDSA-N

InChI=1S/C73H111N17O21.2ClH/c1-38(2)17-14-20-43-32-56(94)80-53(37-92)69(106)88-59(61(98)62(77)99)71(108)87-52(36-91)63(100)79-35-57(95)89(7)54(30-41-18-10-9-11-19-41)70(107)86-49(29-39(3)4)66(103)81-46(23-15-27-74)64(101)82-47(25-26-58(96)97)65(102)85-51(33-55(76)93)68(105)84-50(31-42-34-78-45-22-13-12-21-44(42)45)67(104)83-48(24-16-28-75)72(109)90(8)60(40(5)6)73(110)111-43;;/h9-13,18-19,21-22,34,38-40,43,46-54,59-61,78,91-92,98H,14-17,20,23-33,35-37,74-75H2,1-8H3,(H2,76,93)(H2,77,99)(H,79,100)(H,80,94)(H,81,103)(H,82,101)(H,83,104)(H,84,105)(H,85,102)(H,86,107)(H,87,108)(H,88,106)(H,96,97);2*1H/t43-,46-,47+,48-,49+,50-,51-,52+,53+,54-,59-,60+,61-;;/m1../s1

HIDE SMILES / InChI

Molecular Formula	C73H111N17O21
Molecular Weight	1562.7666
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	13 / 13
E/Z Centers	2
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.4609
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9917006 | https://www.ncbi.nlm.nih.gov/pubmed/29019678 | https://adisinsight.springer.com/drugs/800011609

Lotilibcin (WAP-8294A2) is an antibiotic originally isolated from Lysobacter sp. It is active against methicillin-resistant gram-positive bacteria. Lotilibcin antimicrobial activity is due to lysis of the bacterial membrane, and its membrane-disrupting effect depends on the presence of menaquinone, an essential factor for the bacterial respiratory chain. It was developing for the treatment of susceptible bacterial infections

Originator

Approval Year

PubMed

Title	Date	PubMed
Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic.	2018-07-06	29019678
A new anti-MRSA antibiotic complex, WAP-8294A. I. Taxonomy, isolation and biological activities.	1998-10	9917006

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:31:41 GMT 2025` Edited by `admin` on `Mon Mar 31 18:31:41 GMT 2025`
Record UNII	J28HWY0T41
Record Status	`FAILED`
Record Version

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Name

Type

Language

LOTILIBCIN DIHYDROCHLORIDE

Preferred Name

English

LOTILIBCIN HYDROCHLORIDE

Common Name

English

Code System Code Type Description

FDA UNII

J28HWY0T41

Created by admin on Mon Mar 31 18:31:41 GMT 2025 , Edited by admin on Mon Mar 31 18:31:41 GMT 2025

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PUBCHEM

76971929

Created by admin on Mon Mar 31 18:31:41 GMT 2025 , Edited by admin on Mon Mar 31 18:31:41 GMT 2025

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LOTILIBCIN

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