U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Jun 26 17:21:02 UTC 2021
Edited
by admin
on Sat Jun 26 17:21:02 UTC 2021
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
J0FI6WE1QN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
REGN-10933
Preferred Name English
CASIRIVIMAB
USAN   INN  
Official Name English
CASIRIVIMAB [USAN]
Common Name English
IMMUNOGLOBULIN G1, ANTI-(SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 SPIKE GLYCOPROTEIN) (HUMAN MONOCLONAL REGN10933 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL REGN10933 .KAPPA.-CHAIN, DIMER
Common Name English
REGN10933
Code English
CASIRIVIMAB [INN]
Common Name English
CASIRIVIMAB [WHO-DD]
Common Name English
Code System Code Type Description
INN
11861
Created by admin on Sat Jun 26 17:21:03 UTC 2021 , Edited by admin on Sat Jun 26 17:21:03 UTC 2021
PRIMARY
NCI_THESAURUS
C177087
Created by admin on Sat Jun 26 17:21:03 UTC 2021 , Edited by admin on Sat Jun 26 17:21:03 UTC 2021
PRIMARY
CAS
2415933-42-3
Created by admin on Sat Jun 26 17:21:03 UTC 2021 , Edited by admin on Sat Jun 26 17:21:03 UTC 2021
PRIMARY
FDA UNII
J0FI6WE1QN
Created by admin on Sat Jun 26 17:21:03 UTC 2021 , Edited by admin on Sat Jun 26 17:21:03 UTC 2021
PRIMARY
LACTMED
Casirivimab
Created by admin on Sat Jun 26 17:21:03 UTC 2021 , Edited by admin on Sat Jun 26 17:21:03 UTC 2021
PRIMARY
From To
1_22 1_96
2_22 2_96
2_147 2_203
2_223 4_214
2_264 2_324
1_147 1_203
2_370 2_428
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_223 3_214
1_229 2_229
1_232 2_232
1_264 1_324
1_370 1_428
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_300
N 2_300
Related Record Type Details
TARGET -> INHIBITOR
In blocking studies, REGN10933, REGN10987, and REGN-COV2 mediated concentration-dependent blockade of SARS-CoV-2 RBD binding to human ACE2 with IC50 values in the subnanomolar range.
IN-VITRO
IC50
TARGET ORGANISM->INHIBITOR
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL