HPA-23

Details

Stereochemistry	ACHIRAL
Molecular Formula	2Na.86O.9Sb.21W.17H4N
Molecular Weight	6685.06
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	2

SHOW SMILES / InChI

Structure Search

SMILES

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a++].[Na++].[Sb+3].[Sb+3].[Sb+3].[Sb+3].[Sb+3].[Sb+3].[Sb+3].[Sb+3].[Sb+3].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6].[W+6]

InChI

InChIKey=HIMFWDDKEANLEL-UHFFFAOYSA-A

InChI=1S/17H3N.2Na.86O.9Sb.21W/h17*1H3;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/q;;;;;;;;;;;;;;;;;2*+2;86*-2;9*+3;21*+6/p+17

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Sb
Molecular Weight	121.76
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	W
Molecular Weight	183.84
Charge	6
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H3N
Molecular Weight	17.0305
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.wikigenes.org/e/chem/e/174770.html | https://www.ncbi.nlm.nih.gov/pubmed/3058016 | Holmberg. S.D. (2008) Scientific Errors and Controversies in the U.S. HIV/AIDS Epidemic, p.150, retrieved from: https://books.google.ru/books?id=nf-xokXdGegC

HPA-23 (ammonium-21-tungsto-9- antimoniate) inhibits retrovirus replication by inhibiting RNA-dependent DNA polymerases and thus could be effective in the treatment of HIV-1 infections and AIDS. HPA-23 inhibits nucleic acid polymerases in vitro and has antiviral activity both in vitro and in vivo. Furthermore, HPA-23 inhibits HIV-1 reverse transcriptase in vitro. Inhibition occurred when treatment with HPA-23 was started 18 to 24 h after infection in the plaque assay but no effect was seen when HPA 23 was added 48 h after virus inoculation. HPA-23 was concentrated in the lysosomes and localized in the macrophages of different tissues (thymus, spleen and bone marrow). By 1986, the National Academy of Science had concluded that no therapeutic benefits for persons infected with HIV could be attributed to HPA-23. It was subsequently abandoned as a treatment option.

Approval Year

Sample Use Guides

In Vitro Use Guide

In vitro studies, in semi-solid agar, have shown an inhibitory effect of increasing concentrations of HPA-23 on the normal human granulocyte-macrophage progenitor cells colony and cluster formation. This effect is probably dose-dependent. An almost complete inhibition of colony formation was observed at doses of more than 20 ug/ml.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:37:36 UTC 2023` Edited by `admin` on `Sat Dec 16 04:37:36 UTC 2023`
Record UNII	J08H62IZC9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HPA-23

Common Name

English

AMMONIUM 21-TUNGSTO-9-ANTIMONIATE

Common Name

English

HPA 23

Common Name

English

TUNGSTATE(19-), HEXAOCTACONTAOXONONAANTIMONATEHENEICOSA-, HEPTADECAAMMONIUM DISODIUM

Common Name

English

PM-71

Common Name

English

HPA-23 [MI]

Common Name

English

AMMONIUM ANTIMONY SODIUM TUNGSTEN OXIDE ((NH4)17SB9NA2W21O86)

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

7785