U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C19H23NO2
Molecular Weight 297.3914
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MINAMESTANE

SMILES

[H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])C=CC4=C(N)C(=O)C=C[C@]34C

InChI

InChIKey=DAKHYLIFCYPHQW-KZQROQTASA-N
InChI=1S/C19H23NO2/c1-18-10-8-15(21)17(20)14(18)4-3-11-12-5-6-16(22)19(12,2)9-7-13(11)18/h3-4,8,10-13H,5-7,9,20H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1

HIDE SMILES / InChI

Molecular Formula C19H23NO2
Molecular Weight 297.3914
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Farmitalia-Carlo Erba developed minamestane (code name FCE-24928) as a steroidal aromatase inhibitor for the treatment of cancer. This drug was in phase I clinical trial in Italy, but development was discontinued.

Originator

Approval Year

PubMed

Substance Class Chemical
Record UNII
J02058ABVE
Record Status Validated (UNII)
Record Version