MINAMESTANE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H23NO2
Molecular Weight	297.3914
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])C=CC4=C(N)C(=O)C=C[C@]34C

InChI

InChIKey=DAKHYLIFCYPHQW-KZQROQTASA-N

InChI=1S/C19H23NO2/c1-18-10-8-15(21)17(20)14(18)4-3-11-12-5-6-16(22)19(12,2)9-7-13(11)18/h3-4,8,10-13H,5-7,9,20H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C19H23NO2
Molecular Weight	297.3914
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8422695 | https://adisinsight.springer.com/drugs/800002545

Farmitalia-Carlo Erba developed minamestane (code name FCE-24928) as a steroidal aromatase inhibitor for the treatment of cancer. This drug was in phase I clinical trial in Italy, but development was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
High-performance liquid chromatographic analysis of FCE 24304 (6-methylenandrosta-1,4-diene-3,17-dione) and FCE 24928 (4-aminoandrosta-1,4,6-triene-3,17-dione), two new aromatase inhibitors.	1992 Feb 28	1639908
Antitumor activity of the aromatase inhibitor FCE 24928 on DMBA-induced mammary tumors in ovariectomized rats treated with testosterone.	1993	8422695
High-performance liquid chromatographic determination of FCE 24928, a new aromatase inhibitor, in human plasma.	1994 Feb 4	8148992

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:15:50 GMT 2023` Edited by `admin` on `Fri Dec 15 17:15:50 GMT 2023`
Record UNII	J02058ABVE
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MINAMESTANE

Official Name

English

minamestane [INN]

Common Name

English

4-AMINOANDROSTA-1,4,6-TRIENE-3,17-DIONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2017