Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C27H27N5O2 |
| Molecular Weight | 453.5356 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CCOC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=C4C(CCC4=NO)=C3)C5=CC=NC=C5
InChI
InChIKey=MLSAQOINCGAULQ-QFMPWRQOSA-N
InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,33H,6,10,15-16H2,1-2H3,(H,29,30)/b31-24+
| Molecular Formula | C27H27N5O2 |
| Molecular Weight | 453.5356 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/17145850
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/17145850
SB-590885 is a selective b-Raf inhibitor, developed by GlaxoSmithKline. It inhibited proliferation of BRAF-mutated cells in vitro and slowed down tumor growth in mouse xenograft model of melanoma.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. | 2008-08-01 |
|
| Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. | 2006-12-01 |
|
| The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. | 2006-01-15 |
Patents
Sample Use Guides
In a mouse xenograft model, SB-590885 was administered by i.p. injections at 50 mg/kg.
Route of Administration:
Intraperitoneal
For a proliferation assay, cancer cell lines were treated with SB-590885 in 0.1% DMSO and incubated for 72 hours at 37°C, 5% CO2. Viable cells were quantified using CellTiter-Glo reagent and luminescence detection on a Victor 2V plate reader. SB-590885 inhibits proliferation of BRAF-mutated cells with IC50 0.1 - 0.87 uM.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:10:29 GMT 2025
by
admin
on
Mon Mar 31 21:10:29 GMT 2025
|
| Record UNII |
ISE5ATW631
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
135564599
Created by
admin on Mon Mar 31 21:10:29 GMT 2025 , Edited by admin on Mon Mar 31 21:10:29 GMT 2025
|
PRIMARY | |||
|
ISE5ATW631
Created by
admin on Mon Mar 31 21:10:29 GMT 2025 , Edited by admin on Mon Mar 31 21:10:29 GMT 2025
|
PRIMARY | |||
|
405554-55-4
Created by
admin on Mon Mar 31 21:10:29 GMT 2025 , Edited by admin on Mon Mar 31 21:10:29 GMT 2025
|
PRIMARY | |||
|
DTXSID001025861
Created by
admin on Mon Mar 31 21:10:29 GMT 2025 , Edited by admin on Mon Mar 31 21:10:29 GMT 2025
|
PRIMARY |