BENZODODECINIUM BROMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H38N.Br
Molecular Weight	384.437
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1

InChI

InChIKey=KHSLHYAUZSPBIU-UHFFFAOYSA-M

InChI=1S/C21H38N.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-22(2,3)20-21-17-14-13-15-18-21;/h13-15,17-18H,4-12,16,19-20H2,1-3H3;1H/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula	BrH
Molecular Weight	80.912
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C21H38N
Molecular Weight	304.5331
Charge	1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10657748 | https://www.medicines.org.uk/emc/product/5111/smpc | https://www.sandoz.ca/sites/www.sandoz.ca/files/Timolol%20Maleate-Ex%20Consumer%20information.pdf | https://www.drugs.com/international/benzododecinium.html | https://www.ncbi.nlm.nih.gov/pubmed/21393196 | https://www.ncbi.nlm.nih.gov/pubmed/13238957

Benzododecinium, a quaternary ammonium compound, is an antiseptic agent and disinfectant. Benzododecinium is used as preservative in different pharmaceutical formulations. Thus, the dispenser of Timoptol-LA, used for the treatment of patients with ocular hypertension, contains benzododecinium bromide as a preservative. It is used as preservative and the corneal permeability enhancer in formulation. Benzododecinium is effective against gram-positive microbes.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Spodoptera exigua 3 Target ID: CHEMBL613321 Sources: https://www.ncbi.nlm.nih.gov/pubmed/29175345	Inhibitor 8297
Pseudomonas fluorescens 4 Target ID: CHEMBL612500 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21393196	Inhibitor 8297

PubMed

Title	Date	PubMed
Quaternary ammoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells.	2001 Mar	11222522
Counterion effects on interaction of amphiphilic quaternary ammonium salts with model membranes.	2001 May-Jun	11421457
Controlled drug release from gels using surfactant aggregates. II. Vesicles formed from mixtures of amphiphilic drugs and oppositely charged surfactants.	2001 Nov	11758767
Mikrocalorimetric studies on the interaction of N-dodecyl-N,N-dimethyl-N-benzylammonium halides with phosphatidylcholine bilayers: a counterion effect.	2002	12097968
Interaction between N-dodecyl-N,N-dimethyl-N-benzylammonium halides and phosphatidylcholine bilayers-the effect of counterions.	2003 Apr	12691853
Speciation of vanadium in soil.	2003 Jan 2	18968878
Bactericidal treatment of raw cotton as the method of byssinosis prevention.	2003 Jan-Feb	12570400
Sterol and sterolin-containing products: hematologic adverse reactions.	2004 Apr 13	15108714
Adverse drug reactions in Canada. Hematologic reactions to sterol and sterolin-containing products.	2004 Aug	15455811
Analysis of benzyldimethyldodecylammonium bromide in chemical disinfectants by liquid chromatography and capillary electrophoresis.	2004 Jun 11	15250425
[Preformulation studies of potential drug XIX M: partition coefficient].	2005 Mar	15895969
Architecture of the hydrophobic and hydrophilic layers as found from crystal structure analysis of N-benzyl-N,N-dimethylalkylammonium bromides.	2005 Oct 1	16122544
Identification of benzalkonium chloride in commercial grapefruit seed extracts.	2005 Sep 21	16159196
Molecular mechanism and thermodynamics study of plasmid DNA and cationic surfactants interactions.	2006 Apr 11	16584250
Release characteristics of anionic drug compounds from liquid crystalline gels. Part II. The effects of ion pairing and buffering on the passive delivery of anionic drugs across non-rate-limiting membranes.	2006 Mar 27	16426777
The influence of cholesterol on the interaction between N-dodecyl-N,N-dimethyl-N-benzylammonium halides and phosphatidylcholine bilayers.	2006 Mar-Apr	16729594
Instrument processing with lauryl dimethyl benzyl ammonium bromide: a challenge for patient safety.	2008 Oct	18926316
Surface and volume properties of dodecylethyldimethylammonium bromide and benzyldimethyldodecylammonium bromide: II. Volumetric properties of dodecylethyldimethylammonium bromide and benzyldimethyldodecylammonium bromide.	2009 Feb 15	19013584
Surface and volume properties of dodecylethyldimethylammonium bromide and benzyldimethyldodecylammonium bromide I. Surface properties of dodecylethyldimethylammonium bromide and benzyldimethyldodecylammonium bromide.	2009 Mar 15	19095241
Synthesis of macroporous thermosensitive hydrogels: a novel method of controlling pore size.	2009 Mar 3	19437726
In situ forming polymeric drug delivery systems.	2009 May	20490289
The use of quaternary ammonium disinfectants selects for persisters at high frequency from some species of non-tuberculous mycobacteria and may be associated with outbreaks of soft tissue infections.	2010 Dec	20926395

Patents

Sample Use Guides

In Vivo Use Guide

Ophthalmic use: The 25 uL of test sample was instilled in the lower conjunctival sac of eye and holded for 10 seconds.

Route of Administration: Topical

In Vitro Use Guide

The MIC was found to be 20 mg/L and the MBC was 10 mg/L

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:57:27 UTC 2023` Edited by `admin` on `Fri Dec 15 15:57:27 UTC 2023`
Record UNII	IRY12B2TQ6
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BENZODODECINIUM BROMIDE

Common Name

English

N-DODECYL-N,N-DIMETHYLBENZENEMETHANAMINIUM BROMIDE

Systematic Name

English

Benzododecinium bromide [WHO-DD]

Common Name

English

BENZENEMETHANAMINIUM, N-DODECYL-N,N-DIMETHYL-, BROMIDE

Systematic Name

English

BENZODODECINIUM BROMIDE [MART.]

Common Name

English

AMMONIUM, BENZYLDODECYLDIMETHYL-, BROMIDE

Systematic Name

English

BENZODODECINIUM BROMIDE [II]

Common Name

English

LAURALKONIUM BROMIDE

Official Name

English

LAURALKONIUM BROMIDE [INCI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394