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Details

Stereochemistry RACEMIC
Molecular Formula 2C3H5O3.Mg.2H2O
Molecular Weight 238.4756
Optical Activity ( + / - )
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAGNESIUM LACTATE DIHYDRATE

SMILES

O.O.[Mg++].CC(O)C([O-])=O.CC(O)C([O-])=O

InChI

InChIKey=KSHMINBVGAHXNS-UHFFFAOYSA-L
InChI=1S/2C3H6O3.Mg.2H2O/c2*1-2(4)3(5)6;;;/h2*2,4H,1H3,(H,5,6);;2*1H2/q;;+2;;/p-2

HIDE SMILES / InChI

Molecular Formula C3H6O3
Molecular Weight 90.0779
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula Mg
Molecular Weight 24.305
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Struvite, a crystalline substance first identified in the 18th century, is composed of magnesium ammonium phosphate. Struvite urinary stones are also known as ‘infection stones’, and account for 15%-20% of all urinary stones. Bacterial urease, usually from a Proteus species, is responsible for the chemical changes in urine which result in struvite formation.

Originator

Curator's Comment: Ulex, a Swedish geologist, is generally credited with introduction of the term struvite in1845

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

7.9038723E11
Primary
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

7.9038723E11
Diagnostic
ColPrep Kit

Approved Use

INDICATIONS AND USAGE ColPrep Kit is indicated for cleansing of the colon as a preparation for colonoscopy in adults

Launch Date

1.48279683E12
Primary
MAGNESIUM SULFATE

Approved Use

INDICATIONS AND USAGE Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Launch Date

7.9038723E11
Curative
MagMin

Approved Use

Magnesium aspartate (MagMin) is indicated for patients with documented hypomagnesaemia.
Curative
DELBIASE

Approved Use

Unknown
Primary
DELBIASE

Approved Use

Unknown
Primary
DELBIASE

Approved Use

Unknown
Curative
Magnesium Chloride

Approved Use

Magnesium Chloride injection is indicated as an electrolyte replenisher in magnesium deficiencies
Palliative
Magnesium Chloride

Approved Use

Unknown
Palliative
Magnesium Chloride

Approved Use

Unknown
Primary
EPIMAG

Approved Use

Magnesium citrate is indicated in cases of oxaluria, to prevent recurrence of calcium oxalate kidney stones.
Primary
EPIMAG

Approved Use

Used to relief of occasional constipation (irregularity).
Curative
Magnesium Citrate

Approved Use

Magnesium citrate is indicated to supports magnesium nutritional adequacy.
Curative
Unknown

Approved Use

Magnesium lactate is a naturally occurring mineral that is needed in the body to support the function of the heart, nervous system, and digestive system. Magnesium lactate is used as a mineral supplement to treat magnesium deficiency.
PubMed

PubMed

TitleDatePubMed
Effects of manganese, calcium, magnesium and lithium on the ouabain-induced seizure.
1977
Evidence for separate peptide sequences related to the lipolytic and magnesium-accumulating activities of ACTH. Analogy with adrenergic receptors.
1977 Apr
[Magnesium--an alternative in treatment resistant tachyarrhythmias].
1977 May 30
Serum calcium and magnesium levels in schizophrenia. II. Possible relationship to extrapyramidal symptoms.
1979 Nov
Characterization of the prolactin receptor in human prostate.
1983 Nov
Symptomatic hypercalcaemia precipitated by magnesium therapy.
1985 Jan
Regulation of membrane histamine H1-receptor binding sites by guanine nucleotides, mono- and divalent cations.
1986 Apr
Metal: ATP characteristics of insulin- and epidermal growth factor-stimulated phosphorylation in detergent extracts of rat liver plasma membranes.
1986 Sep
Decreased intracellular free magnesium in erythrocytes of spontaneously hypertensive rats.
1987 Mar 30
Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.
1988 Sep 1
Effect of magnesium diet in gentamicin-induced acute renal failure in rats.
1989
Polylysine specifically activates the insulin-dependent insulin receptor protein kinase.
1989 Jun 15
[Arrhythmogenic effect of flecainide--treatment with i.v. magnesium].
1989 Sep
Magnesium inhibits the hypertensive but not the cardiotonic actions of low-dose epinephrine.
1991 Jun
['Cardiac ballet' with and without amiodarone].
1993 Jan 13
Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake.
1994 Feb 18
Cocaine-induced cerebrovasospasm and its possible mechanism of action.
1994 Mar
Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid.
1995 Mar
Effects of felbamate on muscarinic and metabotropic-glutamate agonist-mediated responses and magnesium-free or 4-aminopyridine-induced epileptiform activity in guinea pig olfactory cortex neurons in vitro.
1996 Jun
Effects of antiepileptic drugs on refractory seizures in the intact immature corticohippocampal formation in vitro.
2003 Nov
Low maternal dietary intakes of iron, magnesium, and niacin are associated with spina bifida in the offspring.
2004 Jun
Magnesium influence on morphine--induced pharmacodependence in rats.
2004 Mar
Major and trace elements in whole blood of phlebotomized patients with porphyria cutanea tarda.
2005
Conformational changes in sarcoplasmic reticulum Ca(2+)-ATPase mutants: effect of mutations either at Ca(2+)-binding site II or at tryptophan 552 in the cytosolic domain.
2006 Apr 25
Activation and enzymatic characterization of recombinant human kallikrein 8.
2006 Jun
Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. II. Pervasive developmental disorder-autism.
2006 Mar
Kinetic properties of chimeric class I aldehyde dehydrogenases for retinal isomers.
2006 Oct
The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2.
2006 Oct
Divalent-metal-dependent nucleolytic activity of Cu, Zn superoxide dismutase.
2006 Oct
Multivariate analysis of the selected metals in the hair of cerebral palsy patients versus controls.
2006 Summer
Magnesium attenuates isoproterenol-induced acute cardiac dysfunction and beta-adrenergic desensitization.
2007 Mar
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.
2007 Sep
Interactions between magnesium and psychotropic drugs.
2008 Jun
Treatment of migraine with prophylactic drugs.
2008 Oct
Cocaine use disorders and serum magnesium profile.
2009
Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect.
2009 Dec
AZT-induced oxidative cardiovascular toxicity: attenuation by Mg-supplementation.
2009 Jun
The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation.
2009 Jun 23
Hair tissue mineral analysis and metabolic syndrome.
2009 Sep
Differential effects of divalent manganese and magnesium on the kinase activity of leucine-rich repeat kinase 2 (LRRK2).
2010 Apr 13
Involvement of transient receptor potential melastatin-related 7 (TRPM7) channels in cadmium uptake and cytotoxicity in MC3T3-E1 osteoblasts.
2010 Dec 15
Carcinogenic heavy metals replace Ca2+ for DNA binding and annealing activities of mono-ubiquitinated annexin A1 homodimer.
2010 Oct 1
Metals affect the structure and activity of human plasminogen activator inhibitor-1. II. Binding affinity and conformational changes.
2011 Feb
Metals affect the structure and activity of human plasminogen activator inhibitor-1. I. Modulation of stability and protease inhibition.
2011 Feb
Millimolar Mn2+ influences agonist binding to 5-HT1A receptors by inhibiting guanosine nucleotide binding to receptor-coupled G-proteins.
2011 Jan
Hypoxia induces an increase in intracellular magnesium via transient receptor potential melastatin 7 (TRPM7) channels in rat hippocampal neurons in vitro.
2011 Jun 10
NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2.
2011 May 30
Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes.
2013 Feb 15
Fluorescence lifetime analysis and effect of magnesium ions on binding of NADH to human aldehyde dehydrogenase 1.
2013 Feb 25
Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis.
2013 Jun 15
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Rats: MgF2 dissolved in acetic acid (Mg=0.08 mM, F=0.084 mM) was delivered in the aerosol form https://www.ncbi.nlm.nih.gov/pubmed/20647692
Murine osteomyelitis model: medical pure titanium plates in size of 10 mm × 10 mm × 1 mm were used for the deposition of Magnesium Fluoride (MgF2) film.
Route of Administration: Topical
In Vitro Use Guide
Curator's Comment: Magnesium Chloride
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:47:56 UTC 2023
Edited
by admin
on Fri Dec 15 19:47:56 UTC 2023
Record UNII
IRT310VU4Z
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MAGNESIUM LACTATE DIHYDRATE
EP  
Systematic Name English
MAGNESIUM, BIS(2-(HYDROXY-.KAPPA.O)PROPANOATO-.KAPPA.O)-, DIHYDRATE, (T-4)
Common Name English
MAGNESIUM LACTATE DIHYDRATE [EP MONOGRAPH]
Common Name English
MAGNESIUM LACTATE DIHYDRATE, DL-
Common Name English
MAGNESIUM DL-LACTATE DIHYDRATE
Common Name English
MAGNESIUM LACTATE DIHYDRATE, (±)-
Systematic Name English
Code System Code Type Description
SMS_ID
100000089841
Created by admin on Fri Dec 15 19:47:57 UTC 2023 , Edited by admin on Fri Dec 15 19:47:57 UTC 2023
PRIMARY
CAS
179308-96-4
Created by admin on Fri Dec 15 19:47:57 UTC 2023 , Edited by admin on Fri Dec 15 19:47:57 UTC 2023
PRIMARY
PUBCHEM
71587589
Created by admin on Fri Dec 15 19:47:57 UTC 2023 , Edited by admin on Fri Dec 15 19:47:57 UTC 2023
PRIMARY
FDA UNII
IRT310VU4Z
Created by admin on Fri Dec 15 19:47:57 UTC 2023 , Edited by admin on Fri Dec 15 19:47:57 UTC 2023
PRIMARY
EVMPD
SUB23354
Created by admin on Fri Dec 15 19:47:57 UTC 2023 , Edited by admin on Fri Dec 15 19:47:57 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE