Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C55H85N19O21S2 |
| Molecular Weight | 1412.508 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 19 / 19 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@H]([C@H](O)[C@@H](CCO)NC(=O)[C@@H](NC(=O)C1=C(C)C(N)=NC(=N1)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]2O[C@@H](C)[C@@H](O)[C@H](O)[C@@H]2O[C@H]3O[C@H](CO)[C@@H](O)[C@H](OC(N)=O)[C@@H]3O)C4=CNC=N4)C(=O)N[C@H](C(=O)NCCC5=N[C@H](CS5)C6=NC(=CS6)C(=O)NCCC(N)=N)C(C)(C)O
InChI
InChIKey=UJKRUPHWCPAJIL-CPLCKGKLSA-N
InChI=1S/C55H85N19O21S2/c1-19-32(71-45(74-43(19)60)24(12-30(59)77)66-13-22(56)44(61)83)48(86)72-33(39(25-14-63-18-67-25)93-53-41(37(81)35(79)21(3)91-53)94-52-38(82)40(95-54(62)89)36(80)28(15-76)92-52)49(87)69-23(8-11-75)34(78)20(2)46(84)73-42(55(4,5)90)50(88)65-10-7-31-68-27(17-96-31)51-70-26(16-97-51)47(85)64-9-6-29(57)58/h14,16,18,20-24,27-28,33-42,52-53,66,75-76,78-82,90H,6-13,15,17,56H2,1-5H3,(H3,57,58)(H2,59,77)(H2,61,83)(H2,62,89)(H,63,67)(H,64,85)(H,65,88)(H,69,87)(H,72,86)(H,73,84)(H2,60,71,74)/t20-,21-,22-,23+,24-,27+,28+,33-,34-,35+,36+,37-,38-,39-,40-,41-,42+,52+,53-/m0/s1
| Molecular Formula | C55H85N19O21S2 |
| Molecular Weight | 1412.508 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 19 / 19 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Zorbamycin (U-30,604E), an antibiotic that induced rapid degradation of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) in Bacillus subtilis cells. It was shown that this drug somehow induced a change in the structure or function of the cellular DNA fraction which resulted in rapid breakdown of this fraction. Zorbamycin also possesses antitumor activity.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Zorbamycin has a different DNA sequence selectivity compared with bleomycin and analogues. | 2016-11-15 |
|
| Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892. | 2015-11-17 |
|
| The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892. | 2009-01 |
|
| Mode of action of zorbamycin. | 1971-10 |
|
| Zorbamycin and related antibiotics. I. Production, isolation and characterization. | 1971-08 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:53:24 GMT 2025
by
admin
on
Mon Mar 31 21:53:24 GMT 2025
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| Record UNII |
IQZ99Q218Q
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C2311
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DTXSID80149300
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11056-20-5
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C152965
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70697970
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CHEMBL2105777
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