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Details

Stereochemistry ACHIRAL
Molecular Formula 2Al.O.O4Si.5H2O
Molecular Weight 252.122
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALUMINUM SILICATE PENTAHYDRATE

SMILES

O.O.O.O.O.[O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-]

InChI

InChIKey=UGAINNNYBMXBMH-UHFFFAOYSA-N
InChI=1S/2Al.O4Si.5H2O.O/c;;1-5(2,3)4;;;;;;/h;;;5*1H2;/q2*+3;-4;;;;;;-2

HIDE SMILES / InChI

Molecular Formula O4Si
Molecular Weight 92.0831
Charge -4
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Al
Molecular Weight 26.9815
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula O
Molecular Weight 15.9994
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Aluminium silicate is a compound made from aluminum, oxygen and silicate that can take the form of a mineral as well as combine with water to make a clay. Aluminum silicate comes in three mineral forms: andalusite, kyanite and sillimanite, all of which have the chemical formula Al2SiO5 but have distinct crystal structures. When magnesium aluminum silicate is hydrated it becomes a clay known as kaolin, which is used for treating ailments such as diarrhea and to combat diaper rash as well as rashes from poison oak and poison ivy. When combined with magnesium and hydrated, the result is a clay mixture that sees common use in antacids as well as a thickener for cosmetics and other beauty products. It also appears as an inactive ingredient for deodorants. The kyanite form of aluminium silicate is used to create mullite for industrial use, and this compound is used by the ceramics industry as a refractory, as well as to manufacture electrical insulating materials and heating elements. Aluminium silicate (aluminum oxide silicate), under the brand name Adsorbin among others, is used as antidiarrheal agent and intestinal adsorbent. Kaolin (hydrated aluminum silicate) has traditionally been used internally to control diarrhea. Kaolin has also been used topically as an emollient and drying agent. Specifically, it has been used to dry oozing and weeping poison ivy, poison oak, and poison sumac rashes. It has also been used as a protectant for the temporary relief of anorectal itching and diaper rash.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
PLENDIL 451

Approved Use

Plendil is used in the treatment of high blood pressure; raynaud's syndrome; angina pectoris prophylaxis and belongs to the drug class calcium channel blocking agents. Risk cannot be ruled out during pregnancy.

Launch Date

1991
PubMed

PubMed

TitleDatePubMed
Relationships among the cerebral amyloid peptides and their precursors.
1989
Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite.
2003
COPD: a dust-induced disease?
2005 Oct
Element-based prognostics of occupational pneumoconiosis using micro-proton-induced X-ray emission analysis.
2017 Dec 1
Patents

Sample Use Guides

Diarrhea: 12 years of age and older: 26.2 g after each loose stool every 6 hours until firm stool; do not exceed more than 262 g per 24 hours; do not use longer than 2 days.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 15:42:29 GMT 2023
Edited
by admin
on Sat Dec 16 15:42:29 GMT 2023
Record UNII
IQ2A4DQ696
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALUMINUM SILICATE PENTAHYDRATE
II  
Common Name English
ALUMINUM OXIDE SILICATE (AL2O(SIO4)), HYDRATE (1:5)
Systematic Name English
ALUMINUM SILICATE PENTAHYDRATE [II]
II  
Common Name English
ALUMINIUM SILICATE PENTAHYDRATE
II  
Common Name English
Code System Code Type Description
PUBCHEM
162623523
Created by admin on Sat Dec 16 15:42:29 GMT 2023 , Edited by admin on Sat Dec 16 15:42:29 GMT 2023
PRIMARY
FDA UNII
IQ2A4DQ696
Created by admin on Sat Dec 16 15:42:29 GMT 2023 , Edited by admin on Sat Dec 16 15:42:29 GMT 2023
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE