R-1487

CN1C(=O)C(OC2=C(F)C=C(F)C=C2)=CC3=CN=C(NC4CCOCC4)N=C13

InChIKey=KKKRKRMVJRHDMG-UHFFFAOYSA-N

InChI=1S/C19H18F2N4O3/c1-25-17-11(10-22-19(24-17)23-13-4-6-27-7-5-13)8-16(18(25)26)28-15-3-2-12(20)9-14(15)21/h2-3,8-10,13H,4-7H2,1H3,(H,22,23,24)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Potency
Mitogen-activated protein kinase 14 7 Target ID: Q16539\|\|\|Q8TDX0 Gene ID: 1432.0 Gene Symbol: MAPK14 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21375264	Inhibitor 8297	0.2 nM [Kd]
Mitogen-activated protein kinase 9 4 Target ID: P45984\|\|\|Q15711 Gene ID: 5601.0 Gene Symbol: MAPK9 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21375264	Inhibitor 8297	9.0 nM [Kd]
Mitogen-activated protein kinase 10 3 Target ID: P53779 Gene ID: 5602.0 Gene Symbol: MAPK10 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21375264	Inhibitor 8297	3.0 nM [Kd]
Serine/threonine-protein kinase NLK 2 Target ID: Q9UBE8 Gene ID: 51701.0 Gene Symbol: NLK Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21375264	Inhibitor 8297	6.0 nM [Kd]

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:03:30 GMT 2023` Edited by `admin` on `Sat Dec 16 11:03:30 GMT 2023`
Record UNII	IO0DCY55NQ
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

R-1487

Common Name

English

PYRIDO(2,3-D)PYRIMIDIN-7(8H)-ONE, 6-(2,4-DIFLUOROPHENOXY)-8-METHYL-2-((TETRAHYDRO-2H-PYRAN-4-YL)AMINO)-

Systematic Name

English

6-(2,4-DIFLUOROPHENOXY)-8-METHYL-2-(TETRAHYDROPYRAN-4-YLAMINO)PYRIDO(2,3-D)PYRIMIDIN-7-ONE

Systematic Name

English

R 1487

Code

English

Code System Code Type Description

DRUG BANK

DB06518