CYCLOATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H21NOS
Molecular Weight	215.356
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCSC(=O)N(CC)C1CCCCC1

InChI

InChIKey=DFCAFRGABIXSDS-UHFFFAOYSA-N

InChI=1S/C11H21NOS/c1-3-12(11(13)14-4-2)10-8-6-5-7-9-10/h10H,3-9H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C11H21NOS
Molecular Weight	215.356
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19479950 | http://sitem.herts.ac.uk/aeru/ppdb/en/Reports/188.htm

Cycloate (S-ethyl N-cyclohexyl(N-ethyl)thiocarbamate) is the active ingredient of various herbicide formulations, such as Ro-Neet 6Eand Buranit 74EC, which are commonly used in Central Europe. It belongs to the thiocarbamates (carbamothioates), which aregenerally used as graminicides before emergence of crops. Thiocarbamates are strong inhibitors of very-long-chain fattyacid elongases. It is moderately toxic to mammals, a chilinesterase inhibitor and neurotoxin. It is also moderately toxic to most fauna and flora.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
fatty acid elongase activity 1 Target ID: GO:0009922 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19479950 \| https://www.ncbi.nlm.nih.gov/pubmed/26879870	Inhibitor 8297
Aldehyde dehydrogenase 8 Target ID: CHEMBL3542434 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7968224	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Social functioning, psychological functioning, and quality of life in epilepsy.	2001 Sep	11580765
Cycloate, an inhibitor of fatty acid elongase, modulates the metabolism of very-long-side-chain alkylresorcinols in rye seedlings.	2009 Oct	19479950

Patents

Sample Use Guides

In Vivo Use Guide

mice: 8 mg/kg ip rats: 2000 mg/kg oral

Route of Administration: Other

In Vitro Use Guide

Inhibition of JK-1 and Transgenic mice bone marrow erythroid progenitor stem cells Fatty acid elongase 5 (Elovl5) with 40 uM cycloate suppressed the γ-globin inductive effects of Cis-vaccenic acid

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:47:42 GMT 2023` Edited by `admin` on `Fri Dec 15 17:47:42 GMT 2023`
Record UNII	IMZ37NA07H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CYCLOATE

Common Name

English

R-2063

Code

English

CYCLOATE [HSDB]

Common Name

English

S-ETHYL N-CYCLOHEXYL-N-ETHYLCARBAMOTHIOATE

Systematic Name

English

S-ETHYL CYCLOHEXYL(ETHYL)THIOCARBAMATE

Systematic Name

English

EUREX

Brand Name

English

RO-NEET

Brand Name

English

ETSAN

Brand Name

English

CYCLOATE [ISO]

Common Name

English

R 2063

Code

English

S-ETHYL N-ETHYLCYCLOHEXANECARBAMOTHIOATE

Common Name

English

SABET

Brand Name

English

CARBAMOTHIOIC ACID, N-CYCLOHEXYL-N-ETHYL-, S-ETHYL ESTER

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

41301