LATOZINEMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:27:32 GMT 2025` Edited by `admin` on `Wed Apr 02 11:27:32 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	IKT0XSS2XB
Record Status	`FAILED`
Record Version

Download

Name

Type

Language

LATOZINEMAB

Official Name

English

AL-001

Preferred Name

English

latozinemab [INN]

Common Name

English

AL001

Code

English

Immunoglobulin G1-kappa, anti-[Homo sapiens SORT1 (sortilin 1, Gp95, NT3)], Homo sapiens monoclonal antibody; gamma1 heavy chain Homo sapiens (1-452) [VH (Homo sapiens IGHV4-38-2*01 (99.0%) -(IGHD) -IGHJ6*01 (100%)) CDR-IMGT [9.7.15] (26-34.52-58.97-111)

Common Name

English

Immunoglobulin G1 [239-alanine,240-alanine,336-serine], anti-(human sortilin-1) (human monoclonal AL001 ?1-chain), disulfide with human monoclonal AL001 ?-chain, dimer

Common Name

English

LATOZINEMAB [USAN]

Common Name

English

Latozinemab [WHO-DD]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

605817

Created by admin on Wed Apr 02 11:27:32 GMT 2025 , Edited by admin on Wed Apr 02 11:27:32 GMT 2025

FDA ORPHAN DRUG

680219

Created by admin on Wed Apr 02 11:27:32 GMT 2025 , Edited by admin on Wed Apr 02 11:27:32 GMT 2025

Code System Code Type Description

FDA UNII

IKT0XSS2XB

Created by admin on Wed Apr 02 11:27:32 GMT 2025 , Edited by admin on Wed Apr 02 11:27:32 GMT 2025

PRIMARY

CAS

2376132-27-1

Created by admin on Wed Apr 02 11:27:32 GMT 2025 , Edited by admin on Wed Apr 02 11:27:32 GMT 2025

PRIMARY

NCI_THESAURUS

C179098

Created by admin on Wed Apr 02 11:27:32 GMT 2025 , Edited by admin on Wed Apr 02 11:27:32 GMT 2025

PRIMARY

SMS_ID

100000177906

Created by admin on Wed Apr 02 11:27:32 GMT 2025 , Edited by admin on Wed Apr 02 11:27:32 GMT 2025

PRIMARY

USAN

KL-93

Created by admin on Wed Apr 02 11:27:32 GMT 2025 , Edited by admin on Wed Apr 02 11:27:32 GMT 2025

PRIMARY

INN

11584

Created by admin on Wed Apr 02 11:27:32 GMT 2025 , Edited by admin on Wed Apr 02 11:27:32 GMT 2025

PRIMARY

INN

From	To
1_234	2_234
1_231	2_231
2_225	4_219
1_225	3_219
4_139	4_199
4_23	4_93
3_139	3_199
3_23	3_93
2_372	2_430
2_266	2_326
2_149	2_205
2_22	2_96
1_372	1_430
1_266	1_326
1_149	1_205
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_302
N	2_302

Related Record Type Details


					Z020Y8WIJ4

SORTILIN

TARGET -> INHIBITOR

Qualification:

Kd

Amount:


					Z020Y8WIJ4

SORTILIN

TARGET -> INHIBITOR

Comments:

Prevents the binding of progranulin (PGRN) to SORT with an EC50 of 1.1 nM.

Qualification:

EC50

Amount:

Related Record Type Details


					IKT0XSS2XB

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_452] [2_452]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL