3,4-DICHLORONITROBENZENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H3Cl2NO2
Molecular Weight	192.0
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][N+](=O)C1=CC=C(Cl)C(Cl)=C1

InChI

InChIKey=NTBYINQTYWZXLH-UHFFFAOYSA-N

InChI=1S/C6H3Cl2NO2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H

HIDE SMILES / InChI

Molecular Formula	C6H3Cl2NO2
Molecular Weight	192.0
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Functional characterization of alpha-class glutathione s-transferases from the Turkey (meleagris gallopavo).	2011-11	21876218
Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene.	2010-10-08	20932318
Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate.	2010-10	20440691
Methemoglobinemia induced by 1,2-dichloro-4-nitrobenzene in mice with a disrupted glutathione S-transferase Mu 1 gene.	2010-09	20562208
A simple colorimetric assay for specific detection of glutathione-S transferase activity associated with DDT resistance in mosquitoes.	2010-08-31	20824165
Characterization of xenobiotic metabolizing enzymes in bovine small intestinal mucosa.	2010-06-01	20557447
Biological profile of erucin: a new promising anticancer agent from cruciferous vegetables.	2010-04	22069601
Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes.	2009-07-07	19584930
Diazinon resistance in different selected strains of Chilo suppressalis (Lepidoptera: Crambidae) in northern Iran.	2009-06	19610437
Hepatic and branchial glutathione S-transferases of two fish species: substrate specificity and biotransformation of microcystin-LR.	2009-05	19101655
A novel method for screening the glutathione transferase inhibitors.	2009-03-16	19291299
Response of the cutworm Spodoptera litura to sesame leaves or crude extracts in diet.	2009	20050772
Up-regulation of the glutathione S-transferase system in human liver by polycyclic aromatic hydrocarbons; comparison with rat liver and lung.	2008-07	18388359
Effect of breed upon cytochromes P450 and phase II enzyme expression in cattle liver.	2008-05	18268077
Studies on the glutathione S-transferase proteome of adult Drosophila melanogaster: responsiveness to chemical challenge.	2007-10	17907271
Characterization of Taenia solium cysticerci microsomal glutathione S-transferase activity.	2007-10	17704948
Purification and cloning of a Delta class glutathione S-transferase displaying high peroxidase activity isolated from the German cockroach Blattella germanica.	2007-04	17331184
Characterization of phenotypes in Gstm1-null mice by cytosolic and in vivo metabolic studies using 1,2-dichloro-4-nitrobenzene.	2006-09	16760226
Expression of the theta class GST isozyme, YdfYdf, in low GST dogs.	2006-05	16237518
Comparison of hydrolytic and conjugative biotransformation pathways in horse, cattle, pig, broiler chick, rabbit and rat liver subcellullar fractions.	2006-04	16437303
Modest induction of phase 2 enzyme activity in the F-344 rat prostate.	2006-03-15	16539699
Glutathione S-transferase and insecticide resistance in laboratory strains and field populations of Musca domestica.	2005-08	16156589
A new class of glutathione S-transferase from the hepatopancreas of the red sea bream Pagrus major.	2005-05-15	15610066
Dansyl glutathione as a trapping agent for the quantitative estimation and identification of reactive metabolites.	2005-05	15892584
Glutathione S-transferase T1-1 activity upregulated in transitional cell carcinoma of urinary bladder.	2005-05	15882759
Effects of heavy metals and nitroaromatic compounds on horseradish glutathione S-transferase and peroxidase.	2004-11	15488591
Molecular cloning and characterization of alpha-class glutathione S-transferase genes from the hepatopancreas of red sea bream, Pagrus major.	2004-10-07	15946636
Inhibition of glutathione S-transferases by thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea, in vitro.	2004-09	15234070
Low glutathione S-transferase dogs.	2004-04	14685647
Postnatal development of hepatic oxidative, hydrolytic and conjugative drug-metabolizing enzymes in female horses.	2004-02-13	14738905
Long-term exposure of Sitka spruce seedlings to trichloroacetic acid.	2003-07-01	12875400
Xenobiotic conjugation systems in deer compared with cattle and rat.	2003-01	12524029
Antioxidative, antiproliferative and biochemical effects in HepG2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination.	2003	14732962
Combined effects of cadmium and nickel on testicular xenobiotic metabolizing enzymes in rats.	2002-11	12449241
Complementary DNA cloning, protein expression, and characterization of alpha-class GSTs from Macaca fascicularis liver.	2002-11	12388831
Mutagenic activity of the glutathione S-transferase substrate 1-chloro-2,4-dinitrobenzene (CDNB) in the Salmonella mutagenicity assay.	2002-09-26	12297151
Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme.	2002-09-15	12069689
Expression and characterisation of a Psoroptes ovis glutathione S-transferase.	2002-04-19	11879966
In vitro nephrotoxicity induced by chloronitrobenzenes in renal cortical slices from Fischer 344 rats.	2002-03-24	11879984
The organochlorine pesticide residues and antioxidant enzyme activities in human breast tumors: is there any association?	2002-03	12038708
Purification and characterization of a glutathione S-transferase from the fungus Cunninghamella elegans.	2001-09-25	11583857
Heterologous expression and characterization of alternatively spliced glutathione S-transferases from a single Anopheles gene.	2001-07-26	11439246
Purification and characterization of multiple glutathione S-transferase isozymes from Chironomidae larvae.	2001-06	11423332
Hydroxypropyl-beta-cyclodextrin as delivery system for thyroid hormones, regulating glutathione S-transferase expression in rat hepatocyte co-cultures.	2001-05-01	11301040
Glutathione transferase activities in renal carcinomas and adjacent normal renal tissues: factors influencing renal carcinogenesis induced by xenobiotics.	2001-01	11218045
Cloning and expression of a cDNA for mu-class glutathione S-transferase from rabbit liver.	1995-04-20	7733673
Hepatic glutathione S-transferases in mice fed on a diet containing the anticarcinogenic antioxidant butylated hydroxyanisole. Isolation of mouse glutathione S-transferase heterodimers by gradient elution of the glutathione-Sepharose affinity matrix.	1991-07-15	1859377
The subunit structure of a major glutathione S-transferase form, MT, in rat testis. Evidence for a heterodimer consisting of subunits with different isoelectric points.	1988-10-01	3169012

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 21:01:17 GMT 2025` Edited by `admin` on `Wed Apr 02 21:01:17 GMT 2025`
Record UNII	IJT74JI7FS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

3,4-DICHLORONITROBENZENE

Systematic Name

English

NSC-6295

Preferred Name

English

NSC-99806

Code

English

3,4-DICHLORONITROBENZENE [HSDB]

Common Name

English

1,2-DICHLORO-4-NITROBENZENE

Systematic Name

English

BENZENE, 1,2-DICHLORO-4-NITRO-

Systematic Name

English

1-NITRO-3,4-DICHLOROBENZENE

Systematic Name

English

Code System Code Type Description

CAS

99-54-7