ANTIMONY DICHLOROTRIFLUORIDE

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	2Cl.3F.Sb
Molecular Weight	249.661
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ANTIMONY DICHLOROTRIFLUORIDE

Structure Search

SMILES

[F-].[F-].[F-].[Cl-].[Cl-].[Sb+5]

InChI

InChIKey=NBTDHPWTBVPOSY-UHFFFAOYSA-I

InChI=1S/2ClH.3FH.Sb/h5*1H;/q;;;;;+5/p-5

HIDE SMILES / InChI

Molecular Formula	Sb
Molecular Weight	121.76
Charge	5
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	FH
Molecular Weight	20.0063
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.whocc.no/atcvet/atcvet_index/?code=QR05CA07https://www.ncbi.nlm.nih.gov/pubmed/5295139 | https://www.ncbi.nlm.nih.gov/pubmed/14851220 | https://www.ncbi.nlm.nih.gov/pubmed/8898332
Curator's Comment: description was created based on several sources, including https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7ef48d40-6d63-440b-a73c-46d89f425936

Stibophen (Fuadin), an organic trivalent antimony compound, has been used for many years in the treatment of schistosomiasis. Stibophen is used as treatment of schistosomiasis by intramuscular injection. Stibophen is known to act by selectively inhibiting worm PFK.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
ATP-dependent 6-phosphofructokinase 21 Target ID: Q27778 Gene ID: NA Gene Symbol: PFK Target Organism: Schistosoma mansoni (Blood fluke) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8898332 \| https://www.ncbi.nlm.nih.gov/pubmed/13446367	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Schistosomiasis 32 Sources: https://www.ncbi.nlm.nih.gov/pubmed/193200 https://www.ncbi.nlm.nih.gov/pubmed/193201 https://www.ncbi.nlm.nih.gov/pubmed/13268811 https://www.ncbi.nlm.nih.gov/pubmed/20292219	Curative		Approved 8429	Fuadin Approved Use Schistosomiasis
Unknown 2578

PubMed

Title	Date	PubMed
Laboratory studies on the joint effects of certain tris (p-aminophenyl) carbonium salts and antimonials as antischistosomal drugs.	1965	5295139
Purification, kinetics and inhibition by antimonials of recombinant phosphofructokinase from Schistosoma mansoni.	1996 Oct 30	8898332
Investigation on the pharmacological profile of 2,6-diacetylpyridine bis(benzoylhydrazone) derivatives and their antimony(III) and bismuth(III) complexes.	2012 Jul	22520151

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 07:53:40 GMT 2023` Edited by `admin` on `Sat Dec 16 07:53:40 GMT 2023`
Record UNII	IDW1CUN3K8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ANTIMONY DICHLOROTRIFLUORIDE

Common Name

English

ANTIMONY DICHLOROTRIFLUORIDE [MI]

Common Name

English

ANTIMONY TRIFLUORODICHLORIDE

Common Name

English

DICHLOROTRIFLUOROANTIMONY

Systematic Name

English

ANTIMONY DICHLORIDE TRIFLUORIDE

Systematic Name

English

ANTIMONY CHLORIDE FLUORIDE (SBCL2F3)

Common Name

English

Code System Code Type Description

PUBCHEM

11807053