RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 19:00:01 GMT 2025` Edited by `admin` on `Tue Apr 01 19:00:01 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	ICA29PPR3N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CARD-CONTAINING IL-1 BETA ICE-KINASE

Preferred Name

English

RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2

Common Name

English

RIP-LIKE-INTERACTING CLARP KINASE

Common Name

English

CARDIAK

Common Name

English

RICK

Common Name

English

TYROSINE-PROTEIN KINASE RIPK2

Common Name

English

RECEPTOR-INTERACTING PROTEIN 2

Common Name

English

CARD-CONTAINING INTERLEUKIN-1 BETA-CONVERTING ENZYME-ASSOCIATED KINASE

Common Name

English

RIP2

Common Name

English

Code System Code Type Description

UNIPROT

O43353

Created by admin on Tue Apr 01 19:00:01 GMT 2025 , Edited by admin on Tue Apr 01 19:00:01 GMT 2025

PRIMARY

PHAROS

O43353

Created by admin on Tue Apr 01 19:00:01 GMT 2025 , Edited by admin on Tue Apr 01 19:00:01 GMT 2025

PRIMARY

FDA UNII

ICA29PPR3N

Created by admin on Tue Apr 01 19:00:01 GMT 2025 , Edited by admin on Tue Apr 01 19:00:01 GMT 2025

PRIMARY

Related Record Type Details


					2893X36L7K

GSK-2983559 active metabolite

INHIBITOR -> TARGET

Comments:

RIP2 binding fluorescence polarization (FP) assays

Qualification:

IC50

Amount:


					WJY2LV4368

GSK-2983559

INHIBITOR -> TARGET

Amount:

Structural Modifications

Modification Type	Location Site	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_176]	DEXFOSFOSERINE	VI4F0K069V
AMINO ACID SUBSTITUTION	[1_381]	TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID SUBSTITUTION	[1_474]	TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID SUBSTITUTION	[1_168] [1_363] [1_393] [1_527] [1_529] [1_531] [1_539]	DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL