Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H10F5N3O4S |
Molecular Weight | 411.304 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(NC(N)=O)C=C(NS(=O)(=O)C2=C(F)C(F)=C(F)C(F)=C2F)C=C1
InChI
InChIKey=FSXLOWIFSZNIMV-UHFFFAOYSA-N
InChI=1S/C14H10F5N3O4S/c1-26-7-3-2-5(4-6(7)21-14(20)23)22-27(24,25)13-11(18)9(16)8(15)10(17)12(13)19/h2-4,22H,1H3,(H3,20,21,23)
Molecular Formula | C14H10F5N3O4S |
Molecular Weight | 411.304 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/16133796
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16133796
T-900607 is a pentafluorophenylsulphonamide derivative patented by Tularik Inc. as antiproliferative agent. Antitumor mechanism of T900607 is similar to the vinca alkaloids in terms of disruption of microtubule polymerization but uniquely causes a specific covalent modification of β-tubulin. In preclinical studies, T900607 was shown to bind irreversibly and specifically to the β1, β2, and β4 isotypes of β-tubulin is not a substrate for p-glycoprotein drug pump and has activity in the preclinical setting in MDR models. T900607 was evaluated in human tumor xenografts and showed activity in MX-1, MCF-7, and MCF-7/ADR mammary, C13 ovarian, HT 29 colon, and Caki-1 renal carcinoma as well as lymphoblastic leukemia, with equal or more efficacious effects compared to vinblastine, doxorubicin and paclitaxel. In a clinical trial, T-900607 shows significant toxicity, consisting of thrombocytopenia, nausea/vomiting, fatigue, and apparent cardiac toxicity.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16133796
130 mg/m^2 on day 1 of an every three week cycle.
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:27:09 GMT 2023
by
admin
on
Sat Dec 16 01:27:09 GMT 2023
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Record UNII |
IC9O2HT1X1
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C67421
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C26674
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C508276
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IC9O2HT1X1
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261944-52-9
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9812416
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DB12068
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |