PENPULIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 15:08:09 GMT 2023` Edited by `admin` on `Sat Dec 16 15:08:09 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	IBS1BZ4E4I
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PENPULIMAB

Official Name

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENSPDCD1 (PROGRAMMED CELL DEATH 1, PD-1, PD1, CD279)), MONOCLONAL ANTIBODY (PENPULIMAB)

Common Name

English

penpulimab [INN]

Common Name

English

AK105

Code

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN PROGRAMMED CELL DEATH 1) (HUMAN-MUS MUSCULUS MONOCLONAL AK105 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL AK105 .KAPPA.-CHAIN, DIMER

Common Name

English

ANTI-PD-1 MONOCLONAL ANTIBODY AK105

Common Name

English

PENPULIMAB [USAN]

Common Name

English

AK-105

Code

English

Penpulimab [WHO-DD]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

802020

Created by admin on Sat Dec 16 15:08:09 GMT 2023 , Edited by admin on Sat Dec 16 15:08:09 GMT 2023

Code System Code Type Description

USAN

JK-165

Created by admin on Sat Dec 16 15:08:09 GMT 2023 , Edited by admin on Sat Dec 16 15:08:09 GMT 2023

PRIMARY

INN

11497

Created by admin on Sat Dec 16 15:08:09 GMT 2023 , Edited by admin on Sat Dec 16 15:08:09 GMT 2023

PRIMARY

CAS

2350298-92-7

Created by admin on Sat Dec 16 15:08:09 GMT 2023 , Edited by admin on Sat Dec 16 15:08:09 GMT 2023

PRIMARY

NCI_THESAURUS

C155879

Created by admin on Sat Dec 16 15:08:09 GMT 2023 , Edited by admin on Sat Dec 16 15:08:09 GMT 2023

PRIMARY

FDA UNII

IBS1BZ4E4I

Created by admin on Sat Dec 16 15:08:09 GMT 2023 , Edited by admin on Sat Dec 16 15:08:09 GMT 2023

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_145	2_201
2_221	4_214
2_262	2_322
1_145	1_201
2_368	2_426
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_221	3_214
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					938DNF64FO

PROGRAMMED CELL DEATH PROTEIN 1

TARGET -> INHIBITOR

Comments:

(Biacore) Antigens were immobilized on a sensor chip, and varying concentrations of AK105 (1.56 to 50 nM) were flown over immobilized PD-1 at the flow rate of 30 μL/min.

Interaction Type:

BINDING

Qualification:

Kd

Amount:

Related Record Type Details


					IBS1BZ4E4I

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL