U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 15:08:09 GMT 2023
Edited
by admin
on Sat Dec 16 15:08:09 GMT 2023
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
IBS1BZ4E4I
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PENPULIMAB
USAN   INN  
Official Name English
IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENSPDCD1 (PROGRAMMED CELL DEATH 1, PD-1, PD1, CD279)), MONOCLONAL ANTIBODY (PENPULIMAB)
Common Name English
penpulimab [INN]
Common Name English
AK105
Code English
IMMUNOGLOBULIN G1, ANTI-(HUMAN PROGRAMMED CELL DEATH 1) (HUMAN-MUS MUSCULUS MONOCLONAL AK105 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL AK105 .KAPPA.-CHAIN, DIMER
Common Name English
ANTI-PD-1 MONOCLONAL ANTIBODY AK105
Common Name English
PENPULIMAB [USAN]
Common Name English
AK-105
Code English
Penpulimab [WHO-DD]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 802020
Created by admin on Sat Dec 16 15:08:09 GMT 2023 , Edited by admin on Sat Dec 16 15:08:09 GMT 2023
Code System Code Type Description
USAN
JK-165
Created by admin on Sat Dec 16 15:08:09 GMT 2023 , Edited by admin on Sat Dec 16 15:08:09 GMT 2023
PRIMARY
INN
11497
Created by admin on Sat Dec 16 15:08:09 GMT 2023 , Edited by admin on Sat Dec 16 15:08:09 GMT 2023
PRIMARY
CAS
2350298-92-7
Created by admin on Sat Dec 16 15:08:09 GMT 2023 , Edited by admin on Sat Dec 16 15:08:09 GMT 2023
PRIMARY
NCI_THESAURUS
C155879
Created by admin on Sat Dec 16 15:08:09 GMT 2023 , Edited by admin on Sat Dec 16 15:08:09 GMT 2023
PRIMARY
FDA UNII
IBS1BZ4E4I
Created by admin on Sat Dec 16 15:08:09 GMT 2023 , Edited by admin on Sat Dec 16 15:08:09 GMT 2023
PRIMARY
From To
1_22 1_96
2_22 2_96
2_145 2_201
2_221 4_214
2_262 2_322
1_145 1_201
2_368 2_426
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_221 3_214
1_227 2_227
1_230 2_230
1_262 1_322
1_368 1_426
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_298
N 2_298
Related Record Type Details
TARGET -> INHIBITOR
(Biacore) Antigens were immobilized on a sensor chip, and varying concentrations of AK105 (1.56 to 50 nM) were flown over immobilized PD-1 at the flow rate of 30 μL/min.
BINDING
Kd
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL