Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H9NO2S |
| Molecular Weight | 171.217 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC=C(C=C1)S(N)(=O)=O
InChI
InChIKey=LMYRWZFENFIFIT-UHFFFAOYSA-N
InChI=1S/C7H9NO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H2,8,9,10)
| Molecular Formula | C7H9NO2S |
| Molecular Weight | 171.217 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
p-Toluene sulfonamide was used to prepare the precursor required for synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate. It acts as a derivative of ammonia activated to alkylation by alkyl halides is exemplified by the synthesis of N-tosyl-2,3-dihydroisoindole from o-xylylene dibromide. It is a precursor of N-tosyl imines. Hybrid compounds of tacrine and p-toluenesulfonamide are effective inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with the preferential inhibition of BChE. p-Toluenesulfonamide has been employed as nucleophile during tetrabutylammonium fluoride (TBAF) catalyzed vinyl aziridine opening reaction and as a reagent during selective aziridination of olefins catalyzed by dirhodium (II) caprolactamate.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Bis(mu-N-[2-(eta[5]-cyclopentadienyl)-ethyl]-4-toluenesulfonamido-N,O:O')-bis[bis(trifluoromethanesulfonato-O)-titanium(II)]bis(dichloromethane) solvate. | 2001 Apr |
|
| 1,2-Silyl-migrative cyclization of vinylsilanes bearing an amino group. | 2003 Jan |
|
| Mitochondrial permeability transition induced by novel pyridothiopyranopyrimidine derivatives: potential new antimitochondrial antitumour agents. | 2006 Dec 15 |
|
| Metabolism and effect of para-toluene-sulfonamide on rat liver microsomal cytochrome P450 from in vivo and in vitro studies. | 2006 May |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
|
| Photochromism, anomalous multi-banded fluorescence and laser properties of some amino- and tosyl-amino derivatives of oxadiazole. | 2006 Sep |
|
| An efficient solvent-free synthesis of benzoxanthenes catalyzed by BSA or O-TSA. | 2008 |
|
| 2,2-Dichloro-N-(4-methyl-phenyl-sulfonyl)acetamide. | 2008 Jul 16 |
|
| Sensitivity of nuclear-quadrupole double-resonance detection of half-integer spin nuclei. | 2008 Oct |
|
| 2-Chloro-benzene-sulfonamide. | 2009 Aug 15 |
|
| 2-[(N-Benzyl-4-methyl-benzene-sul-fon-amido)meth-yl]pyridinium nitrate. | 2009 Oct 23 |
|
| Copper-catalyzed cascade syntheses of 2H-benzo[b][1,4]thiazin-3(4H)-ones and quinoxalin-2(1H)-ones through capturing S and N atom respectively from AcSH and TsNH(2). | 2010 Aug 20 |
|
| 4-Chloro-N-(2,3-dichloro-phen-yl)benzene-sulfonamide. | 2010 Dec 24 |
|
| Intramolecular anodic olefin coupling reactions and the synthesis of cyclic amines. | 2010 Mar 3 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:05:41 GMT 2025
by
admin
on
Mon Mar 31 18:05:41 GMT 2025
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| Record UNII |
I8266RI90M
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| Record Status |
Validated (UNII)
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FDA ORPHAN DRUG |
553516
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C156702
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| Related Record | Type | Details | ||
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PARENT -> METABOLITE |
| Related Record | Type | Details | ||
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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PARENT -> IMPURITY |
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