Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H9NO2S |
| Molecular Weight | 171.217 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC=C(C=C1)S(N)(=O)=O
InChI
InChIKey=LMYRWZFENFIFIT-UHFFFAOYSA-N
InChI=1S/C7H9NO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H2,8,9,10)
| Molecular Formula | C7H9NO2S |
| Molecular Weight | 171.217 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
p-Toluene sulfonamide was used to prepare the precursor required for synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate. It acts as a derivative of ammonia activated to alkylation by alkyl halides is exemplified by the synthesis of N-tosyl-2,3-dihydroisoindole from o-xylylene dibromide. It is a precursor of N-tosyl imines. Hybrid compounds of tacrine and p-toluenesulfonamide are effective inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with the preferential inhibition of BChE. p-Toluenesulfonamide has been employed as nucleophile during tetrabutylammonium fluoride (TBAF) catalyzed vinyl aziridine opening reaction and as a reagent during selective aziridination of olefins catalyzed by dirhodium (II) caprolactamate.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Improvement of the synthesis of diphenylmethyl 7beta-(o-hydroxy)benzylideneamino-3-hydroxymethyl-3-cephem-4-carboxylate. | 2001 Aug |
|
| Samarium(0) and 1,1'-dioctyl-4,4'-bipyridinium dibromide: a novel electron-transfer system for the chemoselective reduction of aromatic nitro groups. | 2001 Feb 9 |
|
| Dichloro[N-[3-(eta5-cyclopentadienyl)propyl]-4-toluenesulfonamido-kappa2N,O]titanium(IV). | 2002 Nov |
|
| Alkynyliodonium salts in organic synthesis. Application to the total synthesis of the tropoloisoquinoline alkaloid pareitropone. | 2002 Oct 2 |
|
| 1,2-Silyl-migrative cyclization of vinylsilanes bearing an amino group. | 2003 Jan |
|
| Employment of palladium pincer-complexes in phenylselenylation of organohalides. | 2005 Nov 11 |
|
| Lewis base catalyzed Mannich-type reactions between trimethylsilyl enol ethers and aldimines. | 2006 Jun 23 |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
|
| Human pharmaceuticals, antioxidants, and plasticizers in wastewater treatment plant and water reclamation plant effluents. | 2007 Feb |
|
| Quantitative determination of three sulfonamides in environmental water samples using liquid chromatography coupled to electrospray tandem mass spectrometry. | 2007 Jul 20 |
|
| RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 with a sulfonamide linkage: their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines. | 2008 Oct 1 |
|
| Gemcitabine plus cisplatin chemotherapy with concurrent para-toluenesulfonamide local injection therapy for peripherally advanced nonsmall cell lung cancer larger than 3 cm in the greatest dimension. | 2009 Oct |
|
| Copper-catalyzed cascade syntheses of 2H-benzo[b][1,4]thiazin-3(4H)-ones and quinoxalin-2(1H)-ones through capturing S and N atom respectively from AcSH and TsNH(2). | 2010 Aug 20 |
|
| N-(4-Chloro-benzo-yl)-4-methyl-benzene-sulfonamide. | 2010 Jan 9 |
|
| Intramolecular anodic olefin coupling reactions and the synthesis of cyclic amines. | 2010 Mar 3 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:41:33 GMT 2023
by
admin
on
Fri Dec 15 15:41:33 GMT 2023
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| Record UNII |
I8266RI90M
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| Record Status |
Validated (UNII)
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FDA ORPHAN DRUG |
553516
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DTXSID8029105
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C156702
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