Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C46H73N4O9.Cl |
Molecular Weight | 861.546 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].CCCCCCCCCCCCCCCCCCNC(=O)OC1CCN(CC1)C(=O)OC[C@H](COC(=O)N(CC2=CC=CC=[N+]2CC)C(=O)C3=CC=CC=C3OC)OC
InChI
InChIKey=IXRMFSBOHHRXSS-YPMTVOEDSA-N
InChI=1S/C46H72N4O9.ClH/c1-5-7-8-9-10-11-12-13-14-15-16-17-18-19-20-24-31-47-44(52)59-39-29-33-49(34-30-39)45(53)57-36-40(55-3)37-58-46(54)50(35-38-26-23-25-32-48(38)6-2)43(51)41-27-21-22-28-42(41)56-4;/h21-23,25-28,32,39-40H,5-20,24,29-31,33-37H2,1-4H3;1H/t40-;/m1./s1
Molecular Formula | C46H73N4O9 |
Molecular Weight | 826.0932 |
Charge | 1 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL250 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1663352 |
0.27 nM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11381675
Intravenous Minopafant administration (300 ug or 1200 ug twice daily) was begun within 4 days and continued for 14 days.
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9134961
Curator's Comment: The cultured neurons were exposed to glutamate (1 mM) for 60 min. Twenty-four hours after this exposure, protective effect of E5880 against neuronal damage was tested.
Minopafant (E5880) was tested for its neuroprotective activity in primary neuronal cultures isolated from embryonic rat cerebral cortex. Protective effect was observed in cultures treated with E5880 (P < 0.01 at 10 nM E5880)
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:49:05 GMT 2023
by
admin
on
Fri Dec 15 18:49:05 GMT 2023
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Record UNII |
I7J5MAD9ZU
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Record Status |
Validated (UNII)
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Record Version |
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128420-61-1
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CHEMBL2110618
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7825
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I7J5MAD9ZU
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300000034352
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C170178
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DTXSID7048798
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130990
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ACTIVE MOIETY |
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