U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Jun 26 17:24:09 UTC 2021
Edited
by admin
on Sat Jun 26 17:24:09 UTC 2021
Nucleic Acid Type mRNA VACCINE
Nucleic Acid Subtype TRANSGENE
Sequence Origin VIRAL
Sequence Type COMPLETE
Record UNII
I74C16KK3J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GANULAMERAN
INN  
Official Name English
BNT162B3
Code English
BNT-162B3
Code English
RNA (RECOMBINANT 5'-(1,2-((3'-O-METHYL)M7G-(5'->5')-PPP-AM))-CAPPED ALL URIDINE->N1-METHYLPSEUDOURIDINE-SUBSTITUTED SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 SPIKE GLYCOPROTEIN S1S2 SECRETORY SIGNAL PEPTIDE PLUS RECEPTOR-BINDING DOMAIN FUSION PROTE
Common Name English
GANULAMERAN [INN]
Common Name English
Code System Code Type Description
CAS
2433844-55-2
Created by admin on Sat Jun 26 17:24:09 UTC 2021 , Edited by admin on Sat Jun 26 17:24:09 UTC 2021
PRIMARY
INN
11890
Created by admin on Sat Jun 26 17:24:09 UTC 2021 , Edited by admin on Sat Jun 26 17:24:09 UTC 2021
PRIMARY
FDA UNII
I74C16KK3J
Created by admin on Sat Jun 26 17:24:09 UTC 2021 , Edited by admin on Sat Jun 26 17:24:09 UTC 2021
PRIMARY
NCI_THESAURUS
C177085
Created by admin on Sat Jun 26 17:24:09 UTC 2021 , Edited by admin on Sat Jun 26 17:24:09 UTC 2021
PRIMARY
Sugar Site Range Site Count
D-Ribose (RNA) 1_2-1_1397 1396 / 1397
2'-O-Methyl-Ribose 1_1 1 / 1397
Linkage Site Range Site Count
Phosphate 1_2-1_1397 1396 / 1396
Related Record Type Details
TARGET ORGANISM->INHIBITOR
Related Record Type Details
ACTIVE MOIETY
Designed to produce neutralizing antibody to the SARS-CoV-2 S glycoprotein. The intention is that such antibodies would protect against SARS-CoV-2 infection and its resulting disease, COVID-19

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOSIDE_SUBSTITUTION RESIDUE_SPECIFIC URACIL N1-METHYLPSEUDOURIDINE 09RAD4M6WF
NUCLEOTIDE SUBSTITUTION [1_1] 5'-TERMINUS UNSPECIFIED SUBSTANCE
96281b8a
(not in database)