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Details

Stereochemistry ACHIRAL
Molecular Formula C19H14O5S
Molecular Weight 354.376
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENOLSULFONPHTHALEIN

SMILES

OC1=CC=C(C=C1)C2(OS(=O)(=O)C3=C2C=CC=C3)C4=CC=C(O)C=C4

InChI

InChIKey=BELBBZDIHDAJOR-UHFFFAOYSA-N
InChI=1S/C19H14O5S/c20-15-9-5-13(6-10-15)19(14-7-11-16(21)12-8-14)17-3-1-2-4-18(17)25(22,23)24-19/h1-12,20-21H

HIDE SMILES / InChI

Molecular Formula C19H14O5S
Molecular Weight 354.376
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Phenolsulfonphthalein (Phenol red) is a pH indicator frequently used in cell biology laboratories. In medicine phenolsulfonphthalein is used as a test to help diagnose problems or disease of the kidneys. This test determines how well the kidneys are working. The test is based on the fact that phenol red is excreted almost entirely in the urine. Phenol red solution is administered intravenously, the urine produced is collected. By measuring the amount of phenol red excreted colorimetrically, kidney function can be determined. Phenolsulfonphthalein has being shown to be a mild estrogenic stimulus. Phenolsulfonphthalein as Phenol red thread test is used to diagnose dry eyes syndrome.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
1.5 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Phenol red thread test
Diagnostic
PSP test

PubMed

Sample Use Guides

In Vivo Use Guide
Usual adult and adolescent dose Renal function studies and Residual bladder urine determinations Intravenous (rapid) or intramuscular, 6 mg. Test procedure: Empty bladder; receive injection; empty bladder again
Route of Administration: Intravenous
In Vitro Use Guide
Phenolsulfonphthalein at 10 mM inhibited hIAPP core amyloidogenic peptides aggregation
Substance Class Chemical
Record UNII
I6G9Y0J1OJ
Record Status Validated (UNII)
Record Version