6-CHRYSENAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H13N
Molecular Weight	243.3025
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=CC2=C(C=CC3=C2C=CC=C3)C4=C1C=CC=C4

InChI

InChIKey=KIVUHCNVDWYUNP-UHFFFAOYSA-N

InChI=1S/C18H13N/c19-18-11-17-13-6-2-1-5-12(13)9-10-15(17)14-7-3-4-8-16(14)18/h1-11H,19H2

HIDE SMILES / InChI

Molecular Formula	C18H13N
Molecular Weight	243.3025
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
hypoxanthine phosphoribosyltransferase 1 Target ID: hypoxanthine phosphoribosyltransferase Sources: https://www.ncbi.nlm.nih.gov/pubmed/12773058	Inhibitor 8297		0.6 µM [Ki]

PubMed

Title	Date	PubMed
Effects of cytochrome P1-450 inducers on the cell-surface receptors for epidermal growth factor, phorbol 12,13-dibutyrate, or insulin of cultured mouse hepatoma cells.	1983 Sep 10	6309801
Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols.	1986 Mar 25	3005314
Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.	1989 Jun 15	2655891
Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae.	1990 Dec 25	2271712
Polycyclic aromatic compounds as anticancer agents: structure-activity relationships of chrysene and pyrene derivatives.	2001 Mar	11310593
Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice.	2002 Jul	12117779
Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences.	2002 Jun	12107646
Identification of 6-aminochrysene photoproducts and study of the effect of a humic acid and riboflavin on its photolysis.	2003 Dec 5	14644571
Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat.	2005 Jan	15598702
The stimulatory role of human cytochrome b5 in the bioactivation activities of human CYP1A2, 2A6 and 2E1: a new cell expression system to study cytochrome P450 mediated biotransformation.	2005 Mar	15728263
Comparing cytotoxicity and genotoxicity in HaCaT cells caused by 6-aminochrysene and 5,6-chrysenequinone under ultraviolet A irradiation.	2006 Jul	16833155

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:41:26 GMT 2023` Edited by `admin` on `Fri Dec 15 17:41:26 GMT 2023`
Record UNII	I56L81BL2L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

6-CHRYSENAMINE

Systematic Name

English

CHRYSEN-6-YLAMINE

Systematic Name

English

CHRYSENE, 6-AMINO-

Systematic Name

English

CHRYSONEX

Brand Name

English

CP-1001

Code

English

6-CHRYSENYLAMINE

Systematic Name

English

CHRYSENEX

Brand Name

English

6-CHRYSENAMINE [MI]

Common Name

English

AMINOCHRYSENE, 6-

Systematic Name

English

NSC-80186

Code

English

6-CHRYSYLAMINE

Systematic Name

English

6-AMINOCHRYSENE

Systematic Name

English

Code System Code Type Description

MERCK INDEX

m3528