ORNOPROSTIL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C23H38O6
Molecular Weight	410.5442
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC[C@H](C)C[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CC(=O)CCCCC(=O)OC

InChI

InChIKey=BBRBUTFBTUFFBU-LHACABTQSA-N

InChI=1S/C23H38O6/c1-4-5-8-16(2)13-18(25)11-12-19-20(22(27)15-21(19)26)14-17(24)9-6-7-10-23(28)29-3/h11-12,16,18-21,25-26H,4-10,13-15H2,1-3H3/b12-11+/t16-,18+,19+,20+,21+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C23H38O6
Molecular Weight	410.5442
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: http://pharmrev.aspetjournals.org/content/63/3/471.full
Curator's Comment: Description was created based on several sources, including http://www.genome.jp/dbget-bin/www_bget?D01869

Ornoprostil is a methyl derivative of PGE1 with anti-ulcreative properties developed in Japan. It is a prostaglandin E1 receptor agonist.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
cell growth 21 Target ID: GO:0016049 Sources: http://www.ncbi.nlm.nih.gov/pubmed/1653751	Inhibitor 8297
Prostanoid EP1 receptor 14 Target ID: CHEMBL1811 Sources: http://www.genome.jp/dbget-bin/www_bget?D01869	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Peptic ulcer 72 Sources: http://drugs-about.com/drugs-r/rowok.html	Curative		Approved 8429	Rowok Approved Use Ornoprostil is used for treatment of peptic ulcers

PubMed

Title	Date	PubMed
[Effect of OU-1308 on uterine motility in pregnant rats and monkeys].	1987 Sep	3480845
Roles of endogenous leukotrienes and prostaglandins in the healing of gastric ulcers induced by acetic acid in rats.	1989	2556789
Effects of TY-10957, a stable PGI2 derivative, on gastroduodenal lesions and secretory responses in the rat.	1990	2112498
Gastric cytoprotection by ornoprostil, a PGE1 analogue, in human subjects.	1991	1940194
Effect of synthetic prostaglandin E1 analog (ornoprostil) on gastric emptying and pancreatic polypeptide release after solid-meal ingestion in man.	1991 Jan	1985004
[Prostaglandins: synthetic and pharmacological studies and development].	1992 Jul	1432596
Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence. Possible mediation of prostaglandins.	1996 Oct	8888721
[Effects of NSAIDs and PGE1 analogue on the permeability of human small intestine].	1997 Jul	9277110

Patents

Sample Use Guides

In Vivo Use Guide

Rats: 50 ug/kg/day, orally

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:16:25 GMT 2023` Edited by `admin` on `Fri Dec 15 16:16:25 GMT 2023`
Record UNII	I4LK9LH4DJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ORNOPROSTIL

Official Name

English

ORNOPROSTIL [MI]

Common Name

English

ORNOPROSTIL [JAN]

Common Name

English

ornoprostil [INN]

Common Name

English

ORNOPROSTIL [MART.]

Common Name

English

METHYL (-)-(1R,2R,3R)-3-HYDROXY-2-((E)-(3S,5S)-3-HYDROXY-5-METHYL-1-NONENYL)-.EPSILON.,5-DIOXOCYCLOPENTANEHEPTANOATE

Systematic Name

English

Ornoprostil [WHO-DD]

Common Name

English

RONOK

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78568