Riliprubart

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 00:02:21 GMT 2025` Edited by `admin` on `Wed Apr 02 00:02:21 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED
Sequence Type	COMPLETE
Record UNII	I31869XDP8
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BIVV-020

Preferred Name

English

Riliprubart

Official Name

English

TNT020

Code

English

SAR-445088

Code

English

RILIPRUBART [USAN]

Common Name

English

Immunoglobulin G4 [224-proline,234-glutamic acid,427-lysine,433-serine], anti-(human complement C1s) (human-Mus musculus monoclonal SAR445088 ?4-chain), disulfide with human-Mus musculus monoclonal SAR445088 ?-chain, dimer

Common Name

English

immunoglobulin G4-kappa, anti-[Homo sapiens C1S (complement C1s)], monoclonal antibody; gamma4 heavy chain (1-446) [VH Musmus/Homsap (Mus musculus IGHV14-3*02 (82.7%) -(IGHD) -IGHJ2*01 (92.9%)/Homo sapiens IGHV1-46*02 (75.5%) -(IGHD) -IGHJ4*01 (92.9%) L1

Common Name

English

SAR445088

Common Name

English

Anti-C1s Humanized IgG4 Monoclonal Antibody

Common Name

English

TNT-020

Code

English

riliprubart [INN]

Common Name

English

BIVV020

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

810521

Created by admin on Wed Apr 02 00:02:22 GMT 2025 , Edited by admin on Wed Apr 02 00:02:22 GMT 2025

Code System Code Type Description

SMS_ID

300000011320

Created by admin on Wed Apr 02 00:02:22 GMT 2025 , Edited by admin on Wed Apr 02 00:02:22 GMT 2025

PRIMARY

USAN

MN-38

Created by admin on Wed Apr 02 00:02:22 GMT 2025 , Edited by admin on Wed Apr 02 00:02:22 GMT 2025

PRIMARY

FDA UNII

I31869XDP8

Created by admin on Wed Apr 02 00:02:22 GMT 2025 , Edited by admin on Wed Apr 02 00:02:22 GMT 2025

PRIMARY

NCI_THESAURUS

C199103

Created by admin on Wed Apr 02 00:02:22 GMT 2025 , Edited by admin on Wed Apr 02 00:02:22 GMT 2025

PRIMARY

INN

12577

Created by admin on Wed Apr 02 00:02:22 GMT 2025 , Edited by admin on Wed Apr 02 00:02:22 GMT 2025

PRIMARY

CAS

2756228-76-7

Created by admin on Wed Apr 02 00:02:22 GMT 2025 , Edited by admin on Wed Apr 02 00:02:22 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_133	4_218
2_146	2_202
2_260	2_320
1_133	3_218
2_366	2_424
3_23	3_92
3_138	3_198
4_23	4_92
4_138	4_198
1_146	1_202
1_225	2_225
1_228	2_228
1_260	1_320
1_366	1_424

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					I31869XDP8

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_446] [2_446]	C-TERMINUS	LYSINE		LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL