| Stereochemistry | ABSOLUTE |
| Molecular Formula | C15H24N4O6 |
| Molecular Weight | 356.3743 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)[C@H](N)C(=O)O[C@@H]1[C@@H](CO)O[C@@H](N2C=CC(N)=NC2=O)[C@]1(C)O
InChI
InChIKey=TVRCRTJYMVTEFS-ICGCPXGVSA-N
InChI=1S/C15H24N4O6/c1-7(2)10(17)12(21)25-11-8(6-20)24-13(15(11,3)23)19-5-4-9(16)18-14(19)22/h4-5,7-8,10-11,13,20,23H,6,17H2,1-3H3,(H2,16,18,22)/t8-,10+,11-,13-,15-/m1/s1
| Molecular Formula | C15H24N4O6 |
| Molecular Weight | 356.3743 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Valopicitabine is a nucleoside analog and the orally bioavailable prodrug of NM107 that competitively inhibits HCV NS5B polymerase, causing chain termination. Valopicitabine had been in phase II clinical trial for once-daily oral treatment of Hepatitis C virus infection. However, because of the overall risk/benefit profile of subjects undergoing clinical trials, further development of the drug has been temporarily placed on hold by the Swiss drug major Novartis and USA-based Idenix Pharmaceuticals company and the FDA.
Originator
Approval Year
PubMed
Patents
Sample Use Guides
Treatment with 2CMC (2'-C-methylcytidine ) was initiated 1 h before human norovirus infection with a dose of 100 mg/kg/day divided into two daily treatments (2 × 50 mg/kg) for 7 consecutive days by the subcutaneous route (n = 15).
Route of Administration:
Other
The 50% and 90% effective concentrations (EC50 and EC90) for inhibition of the foot-and-mouth disease virus (FMDV) - induced cytopathic effect (CPE) formation were 6.4+/-3.8 and 10.8+/-5.4 uM. Comparable EC50 values for inhibition of viral RNA synthesis were observed. Treatment of FMDV-infected BHK-21 cells with 77 uM 2'-C-MetCyt resulted in a (1.6-3.2)x10(3)-fold reduction of infectious virus yield.
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SALT/SOLVATE -> PARENT |
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Showing 1 to 1 of 1 entries
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METABOLITE ACTIVE -> PRODRUG |
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Showing 1 to 1 of 1 entries