Details
| Stereochemistry | MIXED |
| Molecular Formula | C26H56N10.2ClH |
| Molecular Weight | 581.712 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC
InChI
InChIKey=BRJJFBHTDVWTCJ-UHFFFAOYSA-N
InChI=1S/C26H56N10.2ClH/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2;;/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36);2*1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C26H56N10 |
| Molecular Weight | 508.7898 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Alexidine dihydrochloride, an antibacterial compound, which is used during endodontic procedures. It is a dibiguanide ahent and is effective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1). It was noted that PTPMT1 could serve as a pharmacological target in the treatment of type II diabetes. Alexidine dihydrochloride is also an apoptosis-promoting agent possessing the anticancer properties.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Lotions and lubricants. | 2001 Mar |
|
| Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. | 2006 Jul 26 |
|
| In the aftermath of the Fusarium keratitis outbreak: What have we learned? | 2007 Dec |
|
| Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics. | 2008 Oct |
|
| Amoebicidal activities of alexidine against 3 pathogenic strains of acanthamoeba. | 2009 Jan |
|
| Pharmacological targeting of the mitochondrial phosphatase PTPMT1. | 2010 May |
|
| Extracellular Paracoccidioides brasiliensis phospholipase B involvement in alveolar macrophage interaction. | 2010 Sep 15 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:12:50 GMT 2023
by
admin
on
Fri Dec 15 17:12:50 GMT 2023
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| Record UNII |
I2A7616PY1
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| Record Status |
Validated (UNII)
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| Record Version |
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I2A7616PY1
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102678
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DTXSID5045881
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1715-30-6
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216-994-6
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