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Details

Stereochemistry ACHIRAL
Molecular Formula C16H33NO3
Molecular Weight 287.4381
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LAURIC DIETHANOLAMIDE

SMILES

CCCCCCCCCCCC(=O)N(CCO)CCO

InChI

InChIKey=AOMUHOFOVNGZAN-UHFFFAOYSA-N
InChI=1S/C16H33NO3/c1-2-3-4-5-6-7-8-9-10-11-16(20)17(12-14-18)13-15-19/h18-19H,2-15H2,1H3

HIDE SMILES / InChI

Molecular Formula C16H33NO3
Molecular Weight 287.4381
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.skinfopedia.com/Lauramide_DEA and http://raw-materials.mckinleyresources.com/Asset/Lauramide-DEA--TDS.pdf

Lauramide DEA is a compound made from a saturated fatty acid called lauric acid and diethanolamine or DEA, an ingredient in some cosmetic products that functions as a wetting agent. Combinations of fatty acids and DEA like lauramide DEA are referred to as diethanolamides. The diethanolamide lauramide DEA is an ingredient in some personal care products including shampoo, hair coloring products, hand soap, bubble baths, bath gels and lotions. In cosmetic and personal care products, lauramide DEA enhances a product’s ability to form and maintain foam. It also increases the viscosity or thickness of products. This gives them a more substantial feel. Without a viscosity-enhancing agent, shampoos and other personal care products would be considered too “runny” by some. Viscosity increasing agents like lauramide DEA are often combined with surfactants to maximize the texture and performance of cosmetic and personal care products that foam like shampoo and bubble bath. Lauramide DEA also serves as an emulsion stabilizer that helps to keep water-soluble and oil-soluble ingredients together in a product. Diethanolamides like lauramide DEA are found in cosmetic and personal care products in concentrations of between 1 and 10%. At these concentrations, the Cosmetic Ingredient Review Expert Panel, a group of independent experts that looks at the safety of cosmetic ingredients, deems lauramide DEA to be safe. This assumes that lauramide DEA isn’t contamined with other ingredients called nitrosating agents. Nitrosating agents interact with lauramide DEA to form nitrosamines, chemicals linked with an increased risk of cancer. This can happen during the manufacture of a product or during storage. Such ingredients must be excluded from products that contain diethanolamides like lauramide DEA, although there are still concerns about contamination. Topically, lauramide DEA can cause mild skin irritation. There are also reports of contact dermatitis and allergic reactions in some people.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Lipase-catalyzed synthesis of fatty acid diethanolamides.
2001 Dec
[Preparation, characterization, and pulmonary delivery of rifapentine liposomes modified by lauric diethanolamide].
2006 Aug
Drug in adhesive type transdermal matrix systems of ondansetron hydrochloride: optimization of permeation pattern using response surface methodology.
2010 Feb
Patents

Patents

Sample Use Guides

For topical application
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:14:54 GMT 2023
Edited
by admin
on Fri Dec 15 15:14:54 GMT 2023
Record UNII
I29I2VHG38
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LAURIC DIETHANOLAMIDE
II  
Common Name English
LAURAMIDE DEA [VANDF]
Common Name English
LAURIC ACID DIETHANOLAMIDE
Common Name English
DIETHANOL LAURAMIDE [VANDF]
Common Name English
N,N-BIS(2-HYDROXYETHYL)DODECANAMIDE
Systematic Name English
LAURYL DIETHANOLAMIDE
Common Name English
Lauramide dea [WHO-DD]
Common Name English
DIETHANOL LAURAMIDE
VANDF  
Systematic Name English
LAUROYL DIETHANOLAMIDE
Common Name English
LAURAMIDE DEA
INCI   VANDF   WHO-DD  
INCI  
Official Name English
ALKAMIDE LE
Brand Name English
DODECANAMIDE, N,N-BIS(2-HYDROXYETHYL)-
Systematic Name English
N,N-DI(2-HYDROXYETHYL)LAURAMIDE [HSDB]
Common Name English
LAURIC ACID DIETHANOLAMINE
Systematic Name English
LAURAMIDE DEA [INCI]
Common Name English
LAURAMIDE DIETHANOLAMIDE (DEA)
Common Name English
LAURIC DIETHANOLAMIDE [II]
Common Name English
N,N-BIS(2-HYDROXYETHYL)LAURAMIDE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C83486
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
EPA PESTICIDE CODE 79018
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
Code System Code Type Description
MESH
C052237
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
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EVMPD
SUB21738
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
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DAILYMED
I29I2VHG38
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
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EPA CompTox
DTXSID5025491
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
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CAS
120-40-1
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SMS_ID
100000130332
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
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EVMPD
SUB42159
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
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NCI_THESAURUS
C77472
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
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HSDB
5586
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
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PUBCHEM
8430
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
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RXCUI
1363705
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
PRIMARY RxNorm
ECHA (EC/EINECS)
204-393-1
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
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FDA UNII
I29I2VHG38
Created by admin on Fri Dec 15 15:14:54 GMT 2023 , Edited by admin on Fri Dec 15 15:14:54 GMT 2023
PRIMARY