Details
| Stereochemistry | UNKNOWN |
| Molecular Formula | C10H9N3O.C3H6O3 |
| Molecular Weight | 277.2759 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
| Stereo Comments | LACTATE |
SHOW SMILES / InChI
SMILES
CC(O)C(O)=O.NC1=CC(=CNC1=O)C2=CC=NC=C2
InChI
InChIKey=DOSIONJFGDSKCQ-UHFFFAOYSA-N
InChI=1S/C10H9N3O.C3H6O3/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7;1-2(4)3(5)6/h1-6H,11H2,(H,13,14);2,4H,1H3,(H,5,6)
| Molecular Formula | C3H6O3 |
| Molecular Weight | 90.0779 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
| Molecular Formula | C10H9N3O |
| Molecular Weight | 187.198 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionSources: http://www.drugbank.ca/drugs/DB01427Curator's Comment: Description was created based on several sources, including
https://www.drugs.com/pro/inamrinone.html
Sources: http://www.drugbank.ca/drugs/DB01427
Curator's Comment: Description was created based on several sources, including
https://www.drugs.com/pro/inamrinone.html
Inamrinone (Amrinone) is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. Inamrinone is a phosphodiesterase inhibitor (PDE3), resulting in increased cAMP and cGMP which leads to an increase in the calcium influx like that caused by beta-agonists resulting in increased inotropic effect. Inamrinone is used in the treatment of congestive heart failure.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL241 Sources: http://www.drugbank.ca/drugs/DB01427 |
16.7 µM [IC50] | ||
Target ID: CHEMBL290 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10644042 |
31.2 µM [IC50] | ||
Target ID: GO:0070527 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14698653 |
61.0 µM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | AMRINONE LACTATE Approved UseFor the short-term management of congestive heart failure. Launch Date2000 |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
5.2 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8513658/ |
0.75 mg/kg 3 times / day steady-state, intravenous dose: 0.75 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
INAMRINONE plasma | Homo sapiens population: UNKNOWN age: NEWBORN sex: FEMALE / MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
245 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8513658/ |
0.75 mg/kg 3 times / day steady-state, intravenous dose: 0.75 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
INAMRINONE plasma | Homo sapiens population: UNKNOWN age: NEWBORN sex: FEMALE / MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
5.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/8513658/ |
0.75 mg/kg 3 times / day steady-state, intravenous dose: 0.75 mg/kg route of administration: Intravenous experiment type: STEADY-STATE co-administered: |
INAMRINONE plasma | Homo sapiens population: UNKNOWN age: NEWBORN sex: FEMALE / MALE food status: UNKNOWN |
Doses
| Dose | Population | Adverse events |
|---|---|---|
198 ug/kg/min 1 times / day single, intravenous Overdose Dose: 198 ug/kg/min, 1 times / day Route: intravenous Route: single Dose: 198 ug/kg/min, 1 times / day Sources: |
unhealthy, 0.208333333333333 Health Status: unhealthy Age Group: 0.208333333333333 Sex: F Sources: |
Other AEs: Death... Other AEs: Death (grade 5) Sources: |
198 ug/kg/min 1 times / day single, intravenous Overdose Dose: 198 ug/kg/min, 1 times / day Route: intravenous Route: single Dose: 198 ug/kg/min, 1 times / day Sources: |
unhealthy, 0.208333333333333 Health Status: unhealthy Age Group: 0.208333333333333 Sex: F Sources: |
Other AEs: Cardiac arrest... |
100 mg 3 times / day multiple, oral Recommended Dose: 100 mg, 3 times / day Route: oral Route: multiple Dose: 100 mg, 3 times / day Sources: |
unhealthy, 49 |
Disc. AE: Pulmonary edema, Cardiac arrest... AEs leading to discontinuation/dose reduction: Pulmonary edema Sources: Cardiac arrest Respiratory distress syndrome Chest pain Palpitations Ventricular ectopic beats |
200 mg 3 times / day multiple, oral Highest studied dose Dose: 200 mg, 3 times / day Route: oral Route: multiple Dose: 200 mg, 3 times / day Sources: |
unhealthy, 53 |
Disc. AE: Diarrhea, Thrombocytopenia... AEs leading to discontinuation/dose reduction: Diarrhea Sources: Thrombocytopenia |
5.8 mg/kg/day 1 times / day multiple, intravenous Recommended Dose: 5.8 mg/kg/day, 1 times / day Route: intravenous Route: multiple Dose: 5.8 mg/kg/day, 1 times / day Sources: |
unhealthy, 59.4 (37-81) Health Status: unhealthy Age Group: 59.4 (37-81) Sex: M+F Sources: |
Disc. AE: Thrombocytopenia... AEs leading to discontinuation/dose reduction: Thrombocytopenia (18.6%) Sources: |
3 mg/kg 1 times / day single, intravenous Recommended Dose: 3 mg/kg, 1 times / day Route: intravenous Route: single Dose: 3 mg/kg, 1 times / day Sources: |
unhealthy, <1 |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Death | grade 5 | 198 ug/kg/min 1 times / day single, intravenous Overdose Dose: 198 ug/kg/min, 1 times / day Route: intravenous Route: single Dose: 198 ug/kg/min, 1 times / day Sources: |
unhealthy, 0.208333333333333 Health Status: unhealthy Age Group: 0.208333333333333 Sex: F Sources: |
| Cardiac arrest | 198 ug/kg/min 1 times / day single, intravenous Overdose Dose: 198 ug/kg/min, 1 times / day Route: intravenous Route: single Dose: 198 ug/kg/min, 1 times / day Sources: |
unhealthy, 0.208333333333333 Health Status: unhealthy Age Group: 0.208333333333333 Sex: F Sources: |
|
| Cardiac arrest | Disc. AE | 100 mg 3 times / day multiple, oral Recommended Dose: 100 mg, 3 times / day Route: oral Route: multiple Dose: 100 mg, 3 times / day Sources: |
unhealthy, 49 |
| Chest pain | Disc. AE | 100 mg 3 times / day multiple, oral Recommended Dose: 100 mg, 3 times / day Route: oral Route: multiple Dose: 100 mg, 3 times / day Sources: |
unhealthy, 49 |
| Palpitations | Disc. AE | 100 mg 3 times / day multiple, oral Recommended Dose: 100 mg, 3 times / day Route: oral Route: multiple Dose: 100 mg, 3 times / day Sources: |
unhealthy, 49 |
| Pulmonary edema | Disc. AE | 100 mg 3 times / day multiple, oral Recommended Dose: 100 mg, 3 times / day Route: oral Route: multiple Dose: 100 mg, 3 times / day Sources: |
unhealthy, 49 |
| Respiratory distress syndrome | Disc. AE | 100 mg 3 times / day multiple, oral Recommended Dose: 100 mg, 3 times / day Route: oral Route: multiple Dose: 100 mg, 3 times / day Sources: |
unhealthy, 49 |
| Ventricular ectopic beats | Disc. AE | 100 mg 3 times / day multiple, oral Recommended Dose: 100 mg, 3 times / day Route: oral Route: multiple Dose: 100 mg, 3 times / day Sources: |
unhealthy, 49 |
| Diarrhea | Disc. AE | 200 mg 3 times / day multiple, oral Highest studied dose Dose: 200 mg, 3 times / day Route: oral Route: multiple Dose: 200 mg, 3 times / day Sources: |
unhealthy, 53 |
| Thrombocytopenia | Disc. AE | 200 mg 3 times / day multiple, oral Highest studied dose Dose: 200 mg, 3 times / day Route: oral Route: multiple Dose: 200 mg, 3 times / day Sources: |
unhealthy, 53 |
| Thrombocytopenia | 18.6% Disc. AE |
5.8 mg/kg/day 1 times / day multiple, intravenous Recommended Dose: 5.8 mg/kg/day, 1 times / day Route: intravenous Route: multiple Dose: 5.8 mg/kg/day, 1 times / day Sources: |
unhealthy, 59.4 (37-81) Health Status: unhealthy Age Group: 59.4 (37-81) Sex: M+F Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond. | 2009-12 |
|
| Pharmacological interventions for ischaemia reperfusion injury in liver resection surgery performed under vascular control. | 2009-10-07 |
|
| Pharmacological interventions versus no pharmacological intervention for ischaemia reperfusion injury in liver resection surgery performed under vascular control. | 2009-10-07 |
|
| Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin. | 2009-08-21 |
|
| Design, synthesis and pharmacological evaluation of 6-hydroxy-4-methylquinolin-2(1H)-one derivatives as inotropic agents. | 2009-08 |
|
| Evaluation of preoperative intra-aortic balloon pump in coronary patients with severe left ventricular dysfunction undergoing OPCAB surgery: early and mid-term outcomes. | 2009-07-27 |
|
| The role of phosphodiesterase 3 in endotoxin-induced acute kidney injury. | 2009-06-01 |
|
| Effects of propofol on responses of rat isolated renal arteriole to vasoactive agents. | 2009-01-27 |
|
| Gene expression analysis reveals new possible mechanisms of vancomycin-induced nephrotoxicity and identifies gene markers candidates. | 2009-01 |
|
| Effects of amrinone in an experimental model of hepatic ischemia-reperfusion injury. | 2009-01 |
|
| Vesnarinone represses the fibrotic changes in murine lung injury induced by bleomycin. | 2009 |
|
| Effect of nitric oxide/cyclic guanosine mono-phosphate pathway on gallbladder relaxant response in bile duct-ligated guinea pigs. | 2009 |
|
| Tadalafil in the treatment of erectile dysfunction. | 2008-12 |
|
| The base exchange reaction of NAD+ glycohydrolase: identification of novel heterocyclic alternative substrates. | 2008-11-15 |
|
| Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety. | 2008-05-27 |
|
| Inotropic and chronotropic effects of 6-hydroxy-4-methylquinolin-2(1H)-one derivatives in isolated rat atria. | 2008-04 |
|
| Comparison of the initial hospitalization costs between the patients treated with dobutamine and the patients treated with amrinone for acute decompensated heart failure in a Japanese institute. | 2008-03 |
|
| Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. | 2008-01 |
|
| Peripartum cardiomyopathy: review of the literature. | 2007-10-31 |
|
| [Protection of amrinone against lung injury induced by ischemia/reperfusion in rats]. | 2007-06 |
|
| Cirrhotic cardiomyopathy. | 2007-03-27 |
|
| Investigation of binding proteins for anti-platelet agent K-134 by Drug-Western method. | 2007-02-23 |
|
| [Current approaches to intraoperative diagnosis and treatment of low cardiac output during cardiosurgical operations]. | 2006-12-23 |
|
| Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity. | 2006-12-06 |
|
| Coronary bypass grafting using crossclamp fibrillation does not result in reliable reperfusion of the myocardium when the crossclamp is intermittently released: a prospective cohort study. | 2006-11-21 |
|
| Acute heart failure: inotropic agents and their clinical uses. | 2006-11 |
|
| Treatment of poisoning caused by beta-adrenergic and calcium-channel blockers. | 2006-10-01 |
|
| Proper use of phosphodiesterase inhibitors according to the situations. | 2006-09 |
|
| Alkaline Phosphatases : Structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes. | 2006-06 |
|
| Effect of combining phosphodiesterase III inhibitors with St Thomas Hospital's solution used as transplantation preservative solution in isolated rat hearts. | 2006-06 |
|
| A comparison of three phosphodiesterase type III inhibitors on mechanical and metabolic function in guinea pig isolated hearts. | 2006-06 |
|
| Contractile responses to selective phosphodiesterase inhibitors following chronic beta-adrenoreceptor activation. | 2006-05 |
|
| The effect of amrinone on liver regeneration in experimental hepatic resection model. | 2006-01 |
|
| Bench-to-bedside review: thrombocytopenia-associated multiple organ failure--a newly appreciated syndrome in the critically ill. | 2006 |
|
| Bench-to-bedside review: hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers. | 2006 |
|
| In vivo dilatation of the fetal and postnatal ductus arteriosus by inhibition of phosphodiesterase 3 in rats. | 2006 |
|
| Effects of a phosphodiesterase 3 inhibitor, olprinone, on rhythmical change in tension of human gastroepiploic artery. | 2005-12-28 |
|
| Protective effects of different antioxidants and amrinone on vancomycin-induced nephrotoxicity. | 2005-11 |
|
| Effects of inotropic drugs on mechanical function and oxygen balance in postischemic canine myocardium: comparison of dobutamine, epinephrine, amrinone, and calcium chloride. | 2005-10 |
|
| Differential pharmacologic sensitivities of phosphodiesterase-3 inhibitors among human isolated gastroepiploic, internal mammary, and radial arteries. | 2005-10 |
|
| Effect of amrinone on mucosal permeability in experimental intestinal ischaemia/reperfusion injury. | 2005-07 |
|
| A sensitive and specific high performance liquid chromatographic assay for milrinone in rat and human plasma using a commercially available internal standard and low sample volume. | 2005-06-24 |
|
| The impact of slow rewarming on inotropy, tissue metabolism, and "after drop" of body temperature in pediatric patients. | 2005-06 |
|
| Bench-to-bedside review: Inotropic drug therapy after adult cardiac surgery -- a systematic literature review. | 2005-06 |
|
| Inotropic responses to phosphodiesterase inhibitors in cardiac hypertrophy in rats. | 2005-05-09 |
|
| Phosphodiesterase-III-inhibition with amrinone leads to contracture development in skeletal muscle preparations of malignant hyperthermia susceptible swine. | 2005-04 |
|
| SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure. | 2005-01 |
|
| Meta-analysis of hemodynamic optimization: relationship to methodological quality. | 2005 |
|
| Congenital junctional ectopic tachycardia: presentation and outcome. | 2003-07-01 |
|
| Amrinone for refractory cardiogenic shock following chloroquine poisoning. | 1991 |
Patents
Sample Use Guides
Congestive heart failure
IV
Initially, 0.75 mg/kg as a slow (over 2–3 minutes) direct injection; if warranted, may administer a supplemental direct IV dose of 0.75 mg/kg 30 minutes after the initial dose.1 60 Direct IV injection is followed by an IV infusion of 5–10 mcg/kg per minute. Duration of therapy determined by clinical response and tolerance to adverse effects.
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14698653
Inamrinone inhibited human platelet aggregation at 10,800 s(-1) in a dose-dependent manner with the IC(50) value of 61 +/- 8 uM (mean +/- S.D.), Inamrinone significantly inhibited platelet aggregation at 1200 s(-1) only at highest concentration tested (100 uM)
| Substance Class |
Chemical
Created
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on
Edited
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| Record UNII |
I229274Y5B
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| Record Status |
Validated (UNII)
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| Record Version |
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NCI_THESAURUS |
C744
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| Code System | Code | Type | Description | ||
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Inamrinone lactate
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100000085162
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DBSALT001311
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91236
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75898-90-7
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SUB00512MIG
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I229274Y5B
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CHEMBL12856
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C77833
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3035194
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