BROMERGURIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H25BrN4O
Molecular Weight	417.343
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC3=C(Br)NC4=CC=CC(=C34)C1=C[C@@H](CN2C)NC(=O)N(CC)CC

InChI

InChIKey=SBHNNNRQZGYOAU-YVEFUNNKSA-N

InChI=1S/C20H25BrN4O/c1-4-25(5-2)20(26)22-12-9-14-13-7-6-8-16-18(13)15(19(21)23-16)10-17(14)24(3)11-12/h6-9,12,17,23H,4-5,10-11H2,1-3H3,(H,22,26)/t12-,17+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H25BrN4O
Molecular Weight	417.343
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3609071 | https://www.ncbi.nlm.nih.gov/pubmed/1354031 | https://www.ncbi.nlm.nih.gov/pubmed/9369342 | https://www.ncbi.nlm.nih.gov/pubmed/3803415

Bromerguride is an ergot derivative with dopamine antagonistic activity. Bromerguride has been claimed to bind to 5-HT1A receptors and to have 5-HT agonist properties. The neuropharmacological effects caused by the drug in animals were characterized by a central depressant neuroleptic-like symptomatology; the neuroleptic activity of the Bromerguride being at least in the same order of magnitude as haloperidol.

Approval Year

PubMed

Title	Date	PubMed
Novel 8 alpha-ergolines with inhibitory and stimulatory effects on prolactin secretion in rats.	1984 Oct 29	6492995

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:52:05 UTC 2023` Edited by `admin` on `Sat Dec 16 16:52:05 UTC 2023`
Record UNII	HX58M2377W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BROMERGURIDE

Official Name

English

3-(2-BROMO-9,10-DIDEHYDRO-6-METHYLERGOLIN-8.ALPHA.-YL)-1,1-DIETHYLUREA

Systematic Name

English

bromerguride [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66883