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Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 18:30:14 GMT 2023
Edited
by admin
on Sat Dec 16 18:30:14 GMT 2023
Nucleic Acid Type siRNA
Nucleic Acid Subtype
Sequence Type COMPLETE
Record UNII
HX4CRZ94FC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Imdusiran Sodium
USAN  
Official Name English
AB-729
Code English
IMDUSIRAN SODIUM [USAN]
Common Name English
RNA, (Gm-sp-Um-sp-Gm-Cm-(2′-deoxy-2′-fluoro)A-(2′-deoxy-2′-fluoro)C-(2′-deoxy-2′-fluoro)U-Um-Cm-Gm-Cm-Um-Um-Cm-Am-Cm-Am), 3′-[[[rel-(3S,4R)]-1-(9-carboxy-1-oxononyl)-4-(hydroxymethyl)-3,4-dimethyl-3-pyrrolidinyl]methyl hydrogen phosphate],
Common Name English
[1-(10-{[(S)-1,5-Bis({2-[(3,5-bis{[2-(2-{2-[(2-acetamido-2-deoxy-β-D-galactopyranosyl)oxy]ethoxy}ethoxy)ethyl]carbamoyl}phenyl)amino]-2-oxoethyl}amino)-1,5-dioxopentan-2-yl]amino}-10-oxodecanoyl)-4-(hydroxymethyl)-3,4-dimethylpyrrolidin-3-yl]methyl all-
Common Name English
Code System Code Type Description
CAS
2826248-50-2
Created by admin on Sat Dec 16 18:30:14 GMT 2023 , Edited by admin on Sat Dec 16 18:30:14 GMT 2023
PRIMARY
FDA UNII
HX4CRZ94FC
Created by admin on Sat Dec 16 18:30:14 GMT 2023 , Edited by admin on Sat Dec 16 18:30:14 GMT 2023
PRIMARY
USAN
LM-91
Created by admin on Sat Dec 16 18:30:14 GMT 2023 , Edited by admin on Sat Dec 16 18:30:14 GMT 2023
PRIMARY
Sugar Site Range Site Count
2'-Fluoro-Ribose 1_2;1_14;1_16;2_5-2_7 6 / 39
2'-O-Methyl-Ribose 1_1;1_3-1_13;1_15;1_17-1_21;2_1-2_4;2_8-2_17 32 / 39
D-Ribose (RNA) 1_22 1 / 39
Linkage Site Range Site Count
Sodium Phosporothioate 1_2-1_3;1_20-1_21;2_2-2_3 6 / 37
1_4-1_19;1_22;2_4-2_17 31 / 37

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOTIDE SUBSTITUTION [2_17] 3'-TERMINUS UNSPECIFIED SUBSTANCE
15c56e18
(not in database)