U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 18:01:21 GMT 2023
Edited
by admin
on Sat Dec 16 18:01:21 GMT 2023
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
HV8TQI2IKP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Vopikitug
INN  
Official Name English
RG6292
Code English
ANTI-CD25 MONOCLONAL ANTIBODY RO7296682
Common Name English
RO7296682
Code English
RO-7296682
Code English
Immunoglobulin G1-kappa, anti-[Homo sapiens IL2RA (interleukin 2 receptor alpha subunit, IL-2RA, TAC, p55, CD25)], Homo sapiens monoclonal antibody (gamma1 heavy chain Homo sapiens (1-452) [VH (Homo sapiens IGHV1-69*01 (99.0%) -(IGHD) -IGHJ3*02 (100%), C
Common Name English
RG-6292
Code English
vopikitug [INN]
Common Name English
Immunoglobulin G1, anti-(human CD25 antigen) (human monoclonal RG6292 γ1-chain), disulfide with human monoclonal RG6292 κ-chain, dimer
Common Name English
RO 7296682 [WHO-DD]
Common Name English
Code System Code Type Description
FDA UNII
HV8TQI2IKP
Created by admin on Sat Dec 16 18:01:21 GMT 2023 , Edited by admin on Sat Dec 16 18:01:21 GMT 2023
PRIMARY
CAS
2733581-99-0
Created by admin on Sat Dec 16 18:01:21 GMT 2023 , Edited by admin on Sat Dec 16 18:01:21 GMT 2023
PRIMARY
INN
12559
Created by admin on Sat Dec 16 18:01:21 GMT 2023 , Edited by admin on Sat Dec 16 18:01:21 GMT 2023
PRIMARY
NCI_THESAURUS
C173969
Created by admin on Sat Dec 16 18:01:21 GMT 2023 , Edited by admin on Sat Dec 16 18:01:21 GMT 2023
PRIMARY
From To
4_134 4_194
4_23 4_88
3_134 3_194
3_23 3_88
2_372 2_430
2_266 2_326
2_225 4_214
2_149 2_205
2_22 2_96
1_372 1_430
1_266 1_326
1_234 2_234
1_231 2_231
1_225 3_214
1_149 1_205
1_22 1_96
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_302
N 2_302
Related Record Type Details
TARGET->MODULATOR
RO7296682 targets and binds to CD25 expressed on tumor-infiltrating regulatory T (Treg) cells. This may deplete Treg cells and prevent immunosuppression, thereby enhancing anti-tumor immune responses
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL