Vopikitug

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 18:01:21 GMT 2023` Edited by `admin` on `Sat Dec 16 18:01:21 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	HV8TQI2IKP
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Vopikitug

Official Name

English

RG6292

Code

English

ANTI-CD25 MONOCLONAL ANTIBODY RO7296682

Common Name

English

RO7296682

Code

English

RO-7296682

Code

English

Immunoglobulin G1-kappa, anti-[Homo sapiens IL2RA (interleukin 2 receptor alpha subunit, IL-2RA, TAC, p55, CD25)], Homo sapiens monoclonal antibody (gamma1 heavy chain Homo sapiens (1-452) [VH (Homo sapiens IGHV1-69*01 (99.0%) -(IGHD) -IGHJ3*02 (100%), C

Common Name

English

RG-6292

Code

English

vopikitug [INN]

Common Name

English

Immunoglobulin G1, anti-(human CD25 antigen) (human monoclonal RG6292 γ1-chain), disulfide with human monoclonal RG6292 κ-chain, dimer

Common Name

English

RO 7296682 [WHO-DD]

Common Name

English

Code System Code Type Description

FDA UNII

HV8TQI2IKP

Created by admin on Sat Dec 16 18:01:21 GMT 2023 , Edited by admin on Sat Dec 16 18:01:21 GMT 2023

PRIMARY

CAS

2733581-99-0

Created by admin on Sat Dec 16 18:01:21 GMT 2023 , Edited by admin on Sat Dec 16 18:01:21 GMT 2023

PRIMARY

INN

12559

Created by admin on Sat Dec 16 18:01:21 GMT 2023 , Edited by admin on Sat Dec 16 18:01:21 GMT 2023

PRIMARY

NCI_THESAURUS

C173969

Created by admin on Sat Dec 16 18:01:21 GMT 2023 , Edited by admin on Sat Dec 16 18:01:21 GMT 2023

PRIMARY

From	To
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
2_372	2_430
2_266	2_326
2_225	4_214
2_149	2_205
2_22	2_96
1_372	1_430
1_266	1_326
1_234	2_234
1_231	2_231
1_225	3_214
1_149	1_205
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_302
N	2_302

Related Record Type Details


					08TF01H1UT

INTERLEUKIN-2 RECEPTOR SUBUNIT ALPHA

TARGET->MODULATOR

Comments:

RO7296682 targets and binds to CD25 expressed on tumor-infiltrating regulatory T (Treg) cells. This may deplete Treg cells and prevent immunosuppression, thereby enhancing anti-tumor immune responses

Amount:

Related Record Type Details


					HV8TQI2IKP

Vopikitug

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL