Mavrostobart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 10:08:10 GMT 2025` Edited by `admin` on `Wed Apr 02 10:08:10 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4\|KAPPA
Sequence Origin	MOUSE CHIMERIC
Sequence Type	COMPLETE
Record UNII	HT4MAJ8SLE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Mavrostobart

Common Name

English

PT-199

Preferred Name

English

immunoglobulin G4-kappa, anti-[Homo sapiens NT5E (5'-nucleotidase ecto, 5'-nucleotidase, NT5, eN, eNT, NTE, CALJA, CD73)]

Common Name

English

PT199

Code

English

H-gamma4 heavy chain (1-448) [VH Musmus/Homsap (Mus musculus IGHV1-80*01 (77.6%) -(IGHD) -IGHJ3*01 (85.7%) A128>S (121)/Homo sapiens IGHV3-66*01 (71.4%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG4*01, nG

Common Name

English

Immunoglobulin G4 [229-proline], anti-(human CD73 antigen) (human-Mus musculus monoclonal PT199 ?4-chain), disulfide with human-Mus musculus monoclonal PT199 ?-chain, dimer

Common Name

English

mavrostobart [INN]

Common Name

English

Code System Code Type Description

FDA UNII

HT4MAJ8SLE

Created by admin on Wed Apr 02 10:08:10 GMT 2025 , Edited by admin on Wed Apr 02 10:08:10 GMT 2025

PRIMARY

CAS

2928515-12-0

Created by admin on Wed Apr 02 10:08:10 GMT 2025 , Edited by admin on Wed Apr 02 10:08:10 GMT 2025

PRIMARY

NCI_THESAURUS

C190695

Created by admin on Wed Apr 02 10:08:10 GMT 2025 , Edited by admin on Wed Apr 02 10:08:10 GMT 2025

PRIMARY

INN

13259

Created by admin on Wed Apr 02 10:08:10 GMT 2025 , Edited by admin on Wed Apr 02 10:08:10 GMT 2025

PRIMARY

SMS_ID

300000056806

Created by admin on Wed Apr 02 10:08:10 GMT 2025 , Edited by admin on Wed Apr 02 10:08:10 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_135	4_220
2_148	2_204
2_262	2_322
1_135	3_220
2_368	2_426
3_23	3_94
3_140	3_200
4_23	4_94
4_140	4_200
1_148	1_204
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298
N	3_31
N	4_31

Related Record Type Details


					T8635M4C7O

5'-NUCLEOTIDASE

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					HT4MAJ8SLE

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_448] [2_448]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL